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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Orthopaedic implantrelated sarcoma: A study of twelve cases显示文摘 | Keel SB Jaffe KA Petur Nielsen G | 2001 | Mod Pathol2001，14，10： | 1 |
| 3 | Differential expression of microRNA(miRNA)in chordoma reveals a role for miRNA-1 in met expression显示文摘 | Duan Z Choy E Petur Nielsen G | | 0，，06： | 1 |
| 4 | Colon cancer in Iceland-a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age显示文摘 | Petur Snaebjornsson1 Thorvaldur Jonsson | | 0，，： | 1 |
| 5 | In - tube Evaporation and Condensa- tion of R-22 and R-410A with Plain and internally Enhanced Tubes显示文摘 | James Bogart Petur Thors | 1999 | Enhanced Heat Transfer1999，，6： | 1 |
| 6 | In- Tube Evaporation of HCFC-22 with Enhanced Tubes 显示文摘 | Petur Thors James Bogart | | Enhanced Heat Transfer0，1，4： | 1 |
| 7 | Oxygen demand and long term changes of profundal zoobenthos显示文摘 | PETUR M J | 1984 | Hydrobiologia1984，115，： | 1 |
| 8 | Prevalence of recurrent symptoms and their association with epilepsy and febrile seizure in school-aged children:A community-based survey in Iceland显示文摘 | Elisa Baldin Petur Ludvigsson Olafur Mixa | 2012 | Epilepsy & Behavior2012，23，3： | 1 |
| 9 | Epithelioid Vascular Tumors of Bone: A Review and Proposal of a Classification Scheme显示文摘 | John X. O’Connell G. Petur Nielsen Andrew E. Rosenberg | 2001 | Advances in Anatomic Pathology2001，，2： | 1 |
| 10 | Prognostic significance of treatment‐induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy显示文摘 | John T. Mullen Francis J. Hornicek David C. Harmon Kevin A. Raskin Yen‐Lin Chen Jackie Szymonifka Beow Y. Yeap Edwin Choy Thomas F. DeLaney G. Petur Nielsen | 2014 | Cancer2014，，23： | 1 |
| 11 | In - tube evaporation and condensation of R-22 and R-410A with plain and in- ternally enhanced tubes 显示文摘 | James Bogart Petur Thors | 1999 | Enhanced Heat Transfer1999，，6： | 1 |
| 12 | Dedifferentiation in Gastrointestinal Stromal Tumor to an Anaplastic KIT-negative Phenotype: A Diagnostic Pitfall: Morphologic and Molecular Characterization of 8 Cases Occurring Either De Novo or After Imatinib Therapy显示文摘 | Cristina R. Antonescu Salvatore Romeo Lei Zhang Khedoudja Nafa Jason L. Hornick Gunnlaugur Petur Nielsen Mari Mino-Kenudson Hsuan-Ying Huang Juan-Miguel Mosquera Paolo A. Dei Tos Christopher D.M. Fletcher | 2013 | The American Journal of Surgical Pathology2013，，3： | 1 |
| 13 | In-tube evaporation and condensation of R22 and R410A with plain and internally enhanced tubes显示文摘 | James Bogart Petur Thors | 1999 | Enhance Heat Transfer1999，6，： | 1 |
| 14 | Treatment and Outcome of 82 Patients with Angiosarcoma显示文摘 | John A. Abraham Francis J. Hornicek Adam M. Kaufman David C. Harmon Dempsey S. Springfield Kevin A. Raskin Henry J. Mankin David G. Kirsch Andrew E. Rosenberg G. Petur Nielsen Vikram Desphpande Herman D. Suit Thomas F. DeLaney Sam S. Yoon | 2007 | Annals of Surgical Oncology2007，，6： | 1 |
| 15 | Collagen-Rich Tumors of Soft Tissues: An Overview显示文摘 | G. Petur Nielsen John X. O’Connell Bret M. Wehrli Andrew E. Rosenberg | 2003 | Advances in Anatomic Pathology2003，，4： | 1 |
| 16 | In-Tube Evaporation and Condensation of R22 and R410A with Plain and Internally Enhanced Tubes 显示文摘 | James Bogart Petur Thors | 1999 | Enhance Heat Transfer1999，6，： | 1 |
| 17 | In-tube Evaporation and Condensation of R22 and R410A with Plain and Internally Enhanced Tubes 显示文摘 | James Bogart Petur Thors | 1999 | Enhanced Heat Transfer1999，，6： | 1 |
| 18 | In-tube Evaporation of HCFC-22 with Enhanced Tubes 显示文摘 | James Bogart Petur Thors | 1994 | Enhanced Heat Transfer1994，，4： | 1 |
| 19 | Epithelioid Vascular Tumors of Bone: A Review and Proposal of a Classification Scheme显示文摘 | John X. O’Connell G. Petur Nielsen Andrew E. Rosenberg | 2001 | Advances in Anatomic Pathology2001，，2： | 1 |
| 20 | Mortality in takotsubo syndrome is similar to mortality in myocardial infarction — A report from the SWEDEHEART 1 1 Swedish web system for enhancement of evidence-based care in heart disease evaluated according to recommended therapies. registry显示文摘 | Bj?rn Redfors Ramtin Vedad Oskar Anger?s Truls R?munddal Petur Petursson Inger Haraldsson Anwar Ali Christian Dworeck Jacob Odenstedt Dan Ioaness Berglin Libungan Yangzhen Shao Per Albertsson Gregg W. Stone Elmir Omerovic | 2015 | International Journal of Cardiology2015，，： | 1 |
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