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65篇 您的检索式：作者名="Petzold K"

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	题名	作者	年代	出处	被引量
1	星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。	Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊	2019	神经损伤与功能重建2019，14，6：	2
2	Interrupted time series analysis of cost, volume and cost per volume trends in Sweden 1986-2002显示文摘	Andersson K Petzold M G Christian S	2006	Health Policy2006，，79：	1
3	CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis 显示文摘	Rejdak K Eikelenboom MJ Petzold A	2004	Neurology2004，63，8：	1
4	CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis显示文摘	Rejak K Eikelenboom MJ Petzold A		0，，08：	1
5	Effects of generic substitution on the development of pharmaceutical expenditures during the period January 1998 to May 2005 显示文摘	Andersson K Bergstrom G Petzold M	2005	Value in Health2005，8，6：	1
6	CSF nitric oxide metab- olites are associated with activity and progression of multiple sclerosis 显示文摘	Rejdak K Eikelenboom MJ Petzold A	2004	Neurology2004，63，8：	1
7	The numerical solution of higher index differential/algebraic equations by implicit methods 显示文摘	K E Brenan L R Petzold	1989	SIAM Journal on Numerical Analysis (S0036-142)1989，26，4：	1
8	Nampt:linking NAD biology,metabolism and cancer显示文摘	Garten A Petzold S Krner A	2009	Trends Endocrinol Metab2009，20，3：	1
9	CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis显示文摘	Rejdak K Eikelenboom MJ Petzold A	2004	Neurology2004，63，8：	1
10	Synthe- sis and structural studies of pentacycloundecaue-based HIV-1 PR inhibitors: a hybrid 2D NMR and dockingJQM/MM/MD ap- proach显示文摘	MAKATINI MM PETZOLD K SRIHARSHA SN	2011	Eur J Med Chem2011，46，9：	1
11	Synthe- sis, screening and computational investigation of pentacyclounde- cane-peptoids as potent CSA-HIV PR inhibitors 显示文摘	MAKATINI MM PETZOLD K ARVIDSSON PI	2012	Eur J Med Chem2012，57，：	1
12	Vacuum-assisted freeze concentration of sucrose solutions 显示文摘	Petzold G Niranjan K Aguilera J M	2013	Journal of Food Engineering2013，115，3：	1
13	Im- pact of a generic substitution reform on patients' and society's ex- penditure for pharmaceuticals 显示文摘	ANDERSSON K BERGSTROM G PETZOLD MG	2007	Health Policy2007，81，23：	1
14	The numerical solution of initial value problems in ordinary Differential-Algebraic Equations显示文摘	Brenan K E Campbell S L Petzold L R	1996	SIAM Philadelphia1996，，：	1
15	Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type Ⅱ显示文摘	Dreier JP Jurkat-Rott K Petzold GC	2005	Neurology2005，64，：	1
16	Carboxymethyl xylan-synthesis and detailed structure characterization显示文摘	Petzold K Schwikal K Heinze T	2006	Carbohydrate Polymers2006，64，2：	1
17	Synthesis and characterization of methylxylan显示文摘	Heinze T Petzold K Gunther W	2008	Carbohydrate Polymers2008，74，3：	1
18	CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barr6 syndrome显示文摘	Petzold A Brettschneider J Jin K	2009	Muscle Nerve2009，40，1：	1
19	Impact of escitalo- pram on nocturnal sleep, day-time sleepiness and performance compared to amitriptyline: a randomized, double-blind, place- bo-controlled study in healthy male subjects显示文摘	Doerr J Spiegelhalder K Petzold F	2010	Pharmacopsy- chiatria2010，43，5：	1
20	CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis 显示文摘	Rejdak K Eikelenboom M J Petzold A	2004	Neurology2004，63，8：	1

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