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| 1 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 2 | Dyspnea perception in COPD:association between anxiety,dyspnea-related fear,and dyspnea in a pulmonary rehabilitation program 显示文摘 | Janssens T De Peuter S Stans L | 2011 | Chest2011，140，3： | 1 |
| 3 | The influence of fear of symptoms and perceived control on asthma symptom perception 显示文摘 | Janssens T Verleden G De Peuter S | 2011 | J Psychosom Res2011，71，3： | 1 |
| 4 | A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure 显示文摘 | de Peuter OR Lussana F Peters R J | 2009 | Neth J Med2009，67，9： | 1 |
| 5 | Systolic heart fail- ure: A prothrombotic state 显示文摘 | de Peuter OR Kok WE Torp - Pedersen C | 2009 | Semin Thromb Hemost2009，35，5： | 1 |
| 6 | Management strategies for optimal control of anticoagulation patients with atrial fi- brillation显示文摘 | Levi M Peuter OR Kamphuisen PW | 2009 | Semin Thromb Hemost2009，35，6： | 1 |
| 7 | Autobio- graphical memory specificity and affect regulation: coping with a negative life event 显示文摘 | Hermans D de Decker A de Peuter S | 2008 | Depress Anxiety2008，25，9： | 1 |
| 8 | Negative affectivity and enhanced symptom reports: Differentiating between symptoms in men and women显示文摘 | Ilse Van Diest Steven De Peuter Audrey Eertmans Katleen Bogaerts An Victoir Omer Van den Bergh | 2005 | Social Science & Medicine2005，，8： | 1 |
| 9 | Inhibiting NF-κB activation by small molecules as a therapeutic strategy显示文摘 | Gupta S Sundaram C peuter S | 2010 | BBA-Gene Regul Mech2010，1799，： | 1 |
| 10 | Management strategies for optimal control of anticoagulation in patients with atrial fibrillation 显示文摘 | Levi M de Peuter OR Kamphuisen PW | 2009 | Semin Thromb Hemost2009，35，： | 1 |
| 11 | Dyspnea-related anxiety:The Dutch version of the Breathlessness Beliefs Questionnaire 显示文摘 | De Peuter S Janssens T Van Diest I | 2011 | Chron Respir Dis2011，8，1： | 1 |
| 12 | Differential effects of nonselective versus selective beta-blockers on cardiac sympathetic activity and hemostasis in patients with heart failure显示文摘 | Peuter OR Verberne HJ Kok WE | 2013 | J Nucl Med2013，54，10： | 1 |
| 13 | Scientific importance, properties and growing application of poly(3,4-ethylenedioxythiophene)显示文摘 | Stephan Kirchmeyer Knud Peuter | 2005 | J Mater Chem2005，15，： | 1 |
| 14 | Principles of transaction-oriented database recovery显示文摘 | H(ё)rder T Peuter A | 1983 | ACM Computing Surveys1983，12，4： | 1 |
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