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		题名	作者	年代	出处	被引量
	1	Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack显示文摘Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.	Dao Thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong Thu Trang Nguyen Thi Thu Minh Pham Van Cuong Do Thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat	2019	Asian Pacific Journal of Tropical Biomedicine2019，9，1：	1
	2	Studies on characterizing the transmission of RF signals over a turbulent FSO link显示文摘	Pham Tien Dat Abdemoula Bekkali Kamugisha Kazaura	2010	Optics Express2010，17，10：	1
	3	Studies on characterizing the transmission of RF signals over a turbulent FSO link显示文摘	Dat Pham Tien	2009	Optics Express2009，17，10：	1
	4	Studies on characterizing the transmission of RF signals over a turbulent FSO link显示文摘	Pham Tien Dat Abdelmoula Bekkali Kamugisha Kazaura	2010	Optics Express2010，17，10：	1

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