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| 1 | New serological biomarkers of inflammatory bowel disease显示文摘Serological biomarkers in inflammatory bowel disease (IBD) are a rapidly expanding list of non-invasive tests for objective assessments of disease activity, early diagnosis, prognosis evaluation and surveillance. This review summarizes both old and new biomarkers in IBD, but focuses on the development and character-ization of new serological biomarkers (identifi ed since 2007). These include fi ve new anti-glycan antibodies, anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-manobioside IgG (AMCA), and antibod-ies against chemically synthesized (∑) two major oligomannose epitopes, Man α-1,3 Man α-1,2 Man (∑Man3) and Man α-1,3 Man α-1,2 Man α-1,2 Man (∑Man4). These new biomarkers serve as valuable complementary tools to existing biomarkers not only in differentiating Crohn's disease (CD), ulcerative colitis (UC), normal and other non-IBD gut diseases, but also in predicting disease involvement (ileum vs colon), IBD risk (as subclinical biomarkers), and disease course (risk of complication and surgery). Interestingly, the prevalence of the antiglycan antibodies, including anti-Saccharomyces cerevisiae antibodies (ASCA), ALCA and AMCA, was found to be associated with single nucleotide polymorphisms (SNPs) of IBD susceptible genes such as NOD2/CARD15, NOD1/CARD4, toll-likereceptors (TLR) 2 and 4, and β-defensin-1. Further-more, a gene dosage effect was observed: anti-glycan positivity became more frequent as the number of NOD2/CARD15 SNPS increased. Other new serum/ plasma IBD biomarkers reviewed include ubiquitination factor E4A (UBE4A), CXCL16 (a chemokine), resistin, and apolipoprotein A-IV. This review also discusses the most recent studies in IBD biomarker discovery by the application of new technologies such as proteomics, fourier transform near-infrared spectroscopy, and mul-tiplex enzyme-linked immunosorbent assay (ELISA)'s (with an emphasis on cytokine/chemokine profiling). Finally, the prospects of developing more clinically use-ful novel diagnostic algorithms by incorporating new technologies in serological biomarker profiling and integrating multiple biomarkers with bioinformatics analysis/modeling are also discussed. | Xuhang Li Laurie Conklin Philip Alex | 2008 | World Journal of Gastroenterology2008，14，33： | 6 |
| 2 | Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure: Prognostic Value of Heart Rate Variability Measured by an Implanted Cardiac Resynchronization Device显示文摘 | Philip B. Adamson Andrew L. Smith William T. Abraham Karen J. Kleckner Robert W. Stadler Alex Shih Melissa M. Rhodes | 2004 | Circulation2004，，16： | 3 |
| 3 | 美国医改实施:政府间政治与制度设计困境显示文摘《可负担的医疗法案》是在美国两党政治对立的情况下颁布和实施的。本文认为,美国联邦和州政府角色权限的分配,加剧了该法案执行过程中的政治冲突。联邦和州层面的政治参与者(特别是州长和州立法机构)就该法案进行制度协调的不同途径,已经阻碍了医疗保险交易所的建立和医疗救助扩展计划。通过比较,本文认为制度设计时尽量减少政治冲突的医疗保险监管机制改革,在执行过程中大幅度减少了政治摩擦。此外,本文强调了多层次制度设计对实施一些重要改革所产生的政治影响。 | Daniel Beland Philip Rocco Alex Waddan | 2014 | 中国卫生政策研究2014，7，7： | 2 |
| 4 | Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer显示文摘 | Julia Y. S. Tsang Yu-Hua Huang Ming-Hua Luo Yun-Bi Ni Siu-Ki Chan Philip C. W. Lui Alex M. C. Yu Puay Hoon Tan Gary M. Tse | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 5 | Ego depletion, atten- tional control, and decision making in sport 显示文摘 | Philip F Alex B Chris E | 2013 | Psychol- ogy of Sport & Exercise2013，14，6： | 1 |
| 6 | The accuracy of management dividend forecasts in Australia显示文摘 | PHILIP B ALEX C JANICE C Y KADIR L | 2000 | Pacific- Basin finance journal2000，，8： | 1 |
| 7 | Time series sales forecas- ting for short shelf-life food products based on artificial neural networks and evolutionary computing显示文摘 | Philip D Alex A Panagiotis P | | 0，，75： | 1 |
| 8 | InterPro in 2011 :new developments in the family and domain prediction da- tahase显示文摘 | Sarah Hunter Philip Jones Alex Mitchell | 2012 | Nucleic Acids Res2012，40，1： | 1 |
| 9 | An indirect comparison, via enoxaparin, of rivaroxaban with dabigatran in the prevention of venous thromboembolism after hip or knee replacement显示文摘 | Corinne LeReun Philip Wells Alex Diamantopoulos Farhat Rasul Michael Lees Nishan Sengupta | 2011 | Journal of Medical Economics2011，，： | 1 |
| 10 | Ego depletion attentive control, and decision making in sport 显示文摘 | PHILIP F ALEX B CHRIS E | 2013 | Psychology of Sport & Exercise2013，14，6： | 1 |
| 11 | Ego depletion, attentive control, and decision making in sport 显示文摘 | PHILIP F ALEX B CHRIS E | 2013 | Psychol Sport Exe2013，14，6： | 1 |
| 12 | A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621显示文摘 | Julian R. Molina Nathan R. Foster Thanyanan Reungwetwattana Garth D. Nelson Andrew V. Grainger Preston D. Steen Philip J. Stella Randolph Marks John Wright Alex A. Adjei | 2014 | Lung Cancer2014，，： | 1 |
| 13 | Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients*显示文摘 | Alex G. Cuenca Lori F. Gentile M. Cecilia Lopez Ricardo Ungaro Huazhi Liu Wenzhong Xiao Junhee Seok Michael N. Mindrinos Darwin Ang Tezcan Ozrazgat Baslanti Azra Bihorac Philip A. Efron Joseph Cuschieri H. Shaw Warren Ronald G. Tompkins Ronald V. Maier He | 2013 | Critical Care Medicine2013，，5： | 1 |
| 14 | Undiagnosed sleep apnoea syndrome in patients with acute myocardial infarction: Potential importance of the STOP-BANG screening tool for clinical practice显示文摘 | David J. McCormack Ravinder Pabla Mohammed Hilal Babu Linda Dykes Philip Dale R. Andrew Archbold Margaret Pilling Amy Clifford Francesca Cormack Alex Shipolini Alexandra M. Hogan | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 15 | Mapping two Eucalyptus subgenera using multiple endmember spectral mixture analysis and continuum-removed imaging spectrometry data显示文摘 | Kara N. Youngentob Dar A. Roberts Alex A. Held Philip E. Dennison Xiuping Jia David B. Lindenmayer | 2010 | Remote Sensing of Environment2010，，5： | 1 |
| 16 | An indirect comparison, via enoxaparin, of rivaroxaban with dabigatran in the prevention of venous thromboembolism after hip or knee replacement显示文摘 | Corinne LeReun Philip Wells Alex Diamantopoulos Farhat Rasul Michael Lees Nishan Sengupta | 2011 | Journal of Medical Economics2011，，2： | 1 |
| 17 | Denitrification in constructed free-water surface wetlands: I. Very high nitrate removal rates in a macrocosm study显示文摘 | Philip A.M Bachand Alex J Horne | 2000 | Ecological Engineering2000，，1： | 1 |
| 18 | A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women显示文摘 | Pirow JBekker Donna LHolloway Amy SRasmussen RobynMurphy Steven WMartin Philip TLeese Gregory BHolmes Colin RDunstan Alex MDePaoli | 2009 | J Bone Miner Res2009，，7： | 1 |
| 19 | Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models显示文摘 | Sandip Pravin Patel Andrew Bristol Olga Saric Xue-Ping Wang Alex Dubeykovskiy Philip M. Arlen Michael A. Morse | 2013 | Cancer Immunology Immunotherapy2013，，6： | 1 |
| 20 | Conway的数学在Conway之后的发展显示文摘数学家们总是排着队去听JohnConway(康韦)的演讲,钻研他的著作.他们希望享受漂亮的数学,相信自己会得到宝贵的启发.John欢迎这种关注,并将做出更优雅的数学当成自己的责任.他的数学真正宝贵的地方在于其丰富的洞察.他在其工作过的所有领域都留下了供我们探索的康庄大道.John通过多种方式带给我们启发与挑战.他的生命游戏被成千上万的人研究,而他的河流(river)方法则提供了研究经典对象二次型的新方法. | Alex Ryba Philip Ehrlich Richard Kenyon Jeffrey Lagarias James Propp Louis H.Kauffman 范颖玭(译) 楼璐娅(译) 周啸(译) 刘文奡(校) | 2023 | 数学译林2023，42，2： | 0 |
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