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| 1 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 3 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 4 | Efficient inhibition of hepatitis B virus infection by acylated peptides derived fa'om the large viral surface protein显示文摘 | Philippe G Isabelle C and Stephan U | 2005 | J Virol2005，79，3： | 1 |
| 5 | Anfi-inflam matory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation 显示文摘 | Riedel C U Foam F Philippe D | 2006 | World J Gastroenterol2006，2，23： | 1 |
| 6 | GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking显示文摘 | Schneider J Bernges U Philipp M | 2004 | Cancer Lett2004，208，1： | 1 |
| 7 | Electrostatic deflections and electronmechanical resonance of carbon nanotubes显示文摘 | PHILIPPE P WANG Z L DANIEL U | 1999 | Science1999，283，： | 1 |
| 8 | GSTM/, GSTT1, and GSTPI polymorphism and lung cancer risk in relation to tobacco smoking显示文摘 | Schneider J Bernges U Philipp M | 2004 | Cancer Lett2004，208，1： | 1 |
| 9 | Efficient inhibition of hepa titis B virus infection by aeylated peptides derived from the large viral surface protein显示文摘 | Philippe G Isabelle C Stephan U | 2005 | J V iro2005，79，3： | 1 |
| 10 | Radiometric normalization of multitemporal high-resolution satellite images with quality control for land cover change detection 显示文摘 | Yong D U Philippe M T Josef C | 2002 | Remote Sensing of Environment2002，82，1： | 1 |
| 11 | The high-speed rail challenge for big intermediate cities:A national,regional and local pempective显示文摘 | JOSE M U PHILIPPE M MADDI G | 2009 | Cities2009，，26： | 1 |
| 12 | Oral low molecular weight heparin delivery by rnicroparticles from complex coacervation 显示文摘 | ALF L NATHALIE U PHILIPPE M | 2007 | Eur J Pharm Biopharm2007，67，3： | 1 |
| 13 | Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells显示文摘 | Kamouchi M Philipp S Flockerzi V Wissenbach U Mamin A Raeymaekers L | 1999 | J Physiol1999，5182，： | 1 |
| 14 | New Results for Serf - Sensing Active Magnetic Bearings Using Modula- tion Approach 显示文摘 | Alexandre S Raoul H Philipp u | 2005 | IEEE Transactions on Control Sys- tems Technology2005，13，4： | 1 |
| 15 | Modulation of angiogenesis and tumorigenicity of human melanocytic cells by vascular endothelial growth factor and basic fibroblast growth factor显示文摘 | Graeven U Rodeck U Karpinski S Jost M Philippou S Schmiegel W | 2001 | Cancer Res2001，61，： | 1 |
| 16 | Gynaecological cancers in pregnancy显示文摘 | Philippe M Catherine U Sebastien G | | 0，，9815： | 1 |
| 17 | Direct and quantitative AFM measurements of the concentration and temperature dependence of the hydrophobic force law at nanoscopic contacts显示文摘 | PHILIPP S THOMAS U VAL TINER M | 2015 | Journal of Colloid and Interface Science2015，446，： | 1 |
| 18 | Variational B-spline level-set: A linear filtering approach for fast deformable model evolution 显示文摘 | Olivier B Denis F Philippe T and Michael U | 2009 | IEEE Transactions on Image Processing2009，18，6： | 1 |
| 19 | Stream community structure in relation to spatial variation : the influence of mesohabitat characteristics 显示文摘 | BEISEL J N PHILIPPE U P THOMAS S | 1998 | Hydrobiologia1998，389，： | 1 |
| 20 | Heart rate variability and work load measurement显示文摘 | Rohmer W Laurie W Philipp U | 1973 | Ergonomics1973，16，1： | 1 |
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