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| 1 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 2 | Comparison of the expression of the seven ribosomal RNA operons in Escherichia coli显示文摘 | Condon C Philips J Fu Z Y | 1992 | EMBO J1992，11，： | 1 |
| 3 | Clonal propagation of Vanilla planifolia (Sslisb) Ames using tissue culture显示文摘 | Philip V J Nainar A Z | 1986 | J Plant Physiol1986，122，： | 1 |
| 4 | Emerging Bcl-2 inhibitors for the treatment of cancer 显示文摘 | Azmi AS Wang Z Philip PA | 2011 | Expert Opin Emerg Drugs2011，16，1： | 1 |
| 5 | Elevated levels of 8-iso-pros-taglandin F2alpha in pericardial fluid of patients with heartfailure:apotential role for in vivo oxidant stress in ventriculardilatation and progression to heart failure显示文摘 | Mallat Z Philip I Lebret M | 1998 | Circulation1998，97，16： | 1 |
| 6 | Syscan,a kit for detection of anti-candida antibodies for diagnosis of invasive candidiasis显示文摘 | Philip A Odabasi Z Matiuzzi G | 2005 | J Clin Microbial2005，43，9： | 1 |
| 7 | Elevated levels of 8-iso-PGF2α in pericardial fluid of patients with heart failure显示文摘 | Mallat Z Philip I Lebret M | 1998 | Circulation1998，97，16： | 1 |
| 8 | Surgical Neuropathology Update: A Review of Changes Introduced by the WHO Classification of Tumours of the Central Nervous System, 4th Edition显示文摘 | Brat Daniel J Parisi Joseph E Kleinschmidt-DeMasters Bette K Yachnis Anthony T Montine Thomas J Boyer Philip J Powell Suzanne Z Prayson Richard A McLendon Roger E | 2008 | Archives of Pathology & Laboratory Medicine2008，，6： | 1 |
| 9 | Remediation of dichloromethane (CH2Cl2) using non-thermal,atmospheric pressure plasma general in a packed-bed reactor显示文摘 | ABD-ALLAH Z CHRISTOPHER W PHILIP M | 2014 | Environmental Science Technology2014，48，： | 1 |
| 10 | Syscan,a kit for detection of anticandida antibodies for diagnosis of invasive candidiasis显示文摘 | Philip A Odabasi Z Matiuzzi G | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 11 | Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization显示文摘 | LIANG Z YAN PHILIP E DAWSON | 2001 | J Am Chem Soc2001，123，： | 1 |
| 12 | Stability of networked control systems显示文摘 | Michael S B Philips S M | 2001 | IEEE Control Systems Magazine2001，21，2： | 1 |
| 13 | An evaluation of liquid-based cytology and human papillomavirus testing within the UK cervical cancer screening programme显示文摘 | Sherlaw-Johnson C Philips Z | 2004 | Br J Cancer2004，91，1： | 1 |
| 14 | Conditional transgenie expression of TIR - domain - containing adaptor - indu- cing interferon - β (TRIF) in the adult mouse heart is protective in acute viral myoearditis 显示文摘 | Xu Z Desai M Philip J Sivsubramanian N | 2011 | Basic Res Cardiol2011，106，6： | 1 |
| 15 | Geochemical investigation of oils and source rocks from Qianjiang depression of Jianhan basin, a terrigenous saline basin, China显示文摘 | PHILIP R P FAN Z A | 1987 | Organic Geochemistry1987，11，： | 1 |
| 16 | Stability of networked control systems 显示文摘 | WEI Z MICHAEL S B PHILIPS S M | 2001 | IEEE Control Systems Magazine2001，21，2： | 1 |
| 17 | Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice显示文摘 | Philip M Yu Z Michelle B | 2001 | Eur J Neurosci2001，14，： | 1 |
| 18 | Source Apportion- ment of Baltimore Aerosol from Combined Size Distribution and Chemical Composition Data 显示文摘 | David O Philip K H Liming Z | 2006 | Atmospheric Environment2006，40，： | 1 |
| 19 | ALDH-2 deficiency increases cardiovascular oxidative stress-Evidence for indirect antioxidative properties 显示文摘 | PHILIP W JOHANNA M SARAH Z | 2008 | Biochem Biophys Res Commun2008，367，1： | 1 |
| 20 | Geochemical characteristics of aromatic hydrocarbons of crude oils and source rocks from different sedimentary environments显示文摘 | Fan P Philip R P Li Z | 1990 | Organic Geochemistry1990，16，： | 1 |
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