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| 1 | Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor ubiquitously associated with the Epstein-Barr virus(EBV),which is highly prevalent in South China,Southeast Asia,and North Africa.Despite being a highly radio-sensitive and treatable cancer,a majority of NPC patients are diagnosed in their advanced stage,and locoregional and distant relapses following definitive treatment contribute largely to cancer-specific mortality among these patients.Given that EBV-driven NPC is the predominant variant seen in endemic regions,various EBV detection methods have been developed and are utilized in screening,prognostication,and post-treatment surveillance of NPC patients.While the Immunoglobulin A(IgA)serology assay is the most extensively studied EBV detection method,the detection of plasma EBV DNA released during replication or cellular apoptosis has shown superior outcomes in endemic population screening,prognostication,and detection of distant relapse.Furthermore,there is emerging evidence on the use of circulating tumor cells,microRNAs,DNA hypermethylation,and combination assays in various clinical scenarios.Herein,this paper provides a comprehensive overview of the relevant studies using various EBV detection techniques in the management of NPC.Specifically,the recent advances,clinical evidence,and challenges associated with the clinical application of EBV liquid biopsies in population screening,prognostication,and surveillance of NPC are presented. | Rong Tan Sean Kean Ann Phua Yoke Lim Soong Lynette Lin Ean Oon Kian Sing Chan Sasidharan Swarnalatha Lucky Jamie Mong Min Han Tan Chwee Ming Lim | 2020 | Cancer Communications2020，40，11： | 8 |
| 2 | Conjugated hyperbilirubinemia presenting in first fourteen days in term neonates显示文摘AIM To describe the etiology and characteristics of earlyonset conjugated hyperbilirubinemia(ECHB) presenting within 14 d of life in term neonates.METHODS Retrospective review was performed of term infants up to 28-d-old who presented with conjugated hyperbilirubinemia(CHB) at a tertiary center over a 5-year period from January 2010 to December 2014. CHB is defined as conjugated bilirubin(CB) fraction greater than 15% of total bilirubin and CB greater or equal to 25 μmol/L. ECHB is defined as CHB detected within 14 d of life. 'Late-onset' CHB(LCHB) is detected at 15-28 d of life and served as the comparison group.RESULTS Total of 117 patients were recruited: 65 had ECHB, 52had LCHB. Neonates with ECHB were more likely to be clinically unwell(80.0% vs 42.3%, P < 0.001) and associated with non-hepatic causes(73.8% vs 44.2%, P = 0.001) compared to LCHB. Multifactorial liver injury(75.0%) and sepsis(17.3%) were the most common causes of ECHB in clinically unwell infants, majority(87.5%) had resolution of CHB with no progression to chronic liver disease. Inborn errors of metabolism were rare(5.8%) but associated with high mortality(100%) in our series. In the subgroup of clinically well infants(n = 13) with ECHB, biliary atresia(BA) was the most common diagnosis(61.5%), all presented initially with normal stools and decline in total bilirubin but with persistent CHB. CONCLUSION Secondary hepatic injury is the most common reason for ECHB. BA presents with ECHB in well infants without classical symptoms of pale stools and deep jaundice. | Fang Kuan Chiou Christina Ong Kong Boo Phua Fares Chedid Ajmal Kader | 2017 | World Journal of Hepatology2017，9，26： | 3 |
| 3 | 复合树脂修复术的变革显示文摘当今牙科学科发展及临床进展迅猛,新材料及新技术的不断出现让修复学尤其是美学性修复的领域有了极大暴涨性成长。经典的树脂美容修复是众多牙科医生修复牙体缺损微创方式中的首选。然而随着树脂材料本身的发展.对于材料的选用、修复牙位的范围、修复方式及具体技巧的变化,许多医生无法具悉其详。 | T C Phua | 2014 | 中华口腔医学研究杂志(电子版)2014，8，2： | 3 |
| 4 | Glycemic Management in Patients With Coronary Artery Disease and Prediabetes or Type 2 Diabetes Mellitus显示文摘 | Allison B. Goldfine Eng-Joo Phua Martin J. Abrahamson | 2014 | Circulation2014，，24： | 3 |
| 5 | Crystallization and chemi-crystallization of recycled photo-degraded polypropylene显示文摘 | CRAIGA I H WHITE J R PHUA C K | 2005 | Polymer2005，46，2： | 1 |
| 6 | Minority report in fraud detection: classification of skewed data显示文摘 | Phua C Alahakoon D Lee V | 2004 | ACM SIGKDD Explorations News- letter2004，6，1： | 1 |
| 7 | IDSA/ATS minor criteria aid pre-intensive care unit resuscitation in severe community-acquired pneumonia显示文摘 | Lim HF Phua J Mukhopadhyay A | 2014 | Eur Respir J2014，43，3： | 1 |
| 8 | Has mortality from acute respiratory distress syndrome decreased over time:A systematic review显示文摘 | Phua J Badia JR Adhikari NK | 2009 | Am J Respir Cirt Care Med2009，179，： | 1 |
| 9 | Acute respiratory distress syndrome 40 years later:time to revisit its definition 显示文摘 | Phua J Stewart TE Ferguson ND | 2008 | Crit Care Med2008，36，10： | 1 |
| 10 | Has mortality from a- cute respiratory distress syndrome decreased over time: a systematic review 显示文摘 | Phua J Badia JR Adhikari NK | 2009 | Am J Respir Crit Care Med2009，179，3： | 1 |
| 11 | Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs otherconditions: effectiveness and predictors of failure显示文摘 | Phua J Kong K Lee K H | 2005 | Intensive Care Med2005，31，4： | 1 |
| 12 | IDSA/ATS minor criteria aid pre-intensive care unit resuscitation in severe community-acquired pneumonia显示文摘 | Lim HF Phua J Mukhopadhyay A | 2014 | Eur Respir J2014，43，3： | 1 |
| 13 | A hospital-based surveillance of rotavirus gastroenteritis in children<5years of age in Singapore显示文摘 | PHUA K B TEE N LIU Y | 2013 | Pediatr Infect Dis J2013，32，： | 1 |
| 14 | Has mortality from aeute respira- tory distress syndrome decreased over lime 显示文摘 | Phua J Badia JR Adhikari NK | 2009 | Am J Respir Crit Care Med2009，179，3： | 1 |
| 15 | Lactate procalcitonin and am ino-teminalpro B-type natriuretic peptide versus cytokinemeasurements and clinical severity scores for prognostication inseptic shock显示文摘 | Phua J Koay ES Lee KH | 2008 | Shock2008，29，3： | 1 |
| 16 | Lactate,procalcitonin,and amino-ter-minal pro-B-type nalriuretic peptide Velrsus cytokine meas-urements and clinial severity scores for prognostication in septic shock显示文摘 | Phua J Koay ES Lee KH | 2008 | Shock2008，29，3： | 1 |
| 17 | Has mortality from acute respiratory distress syndrome decreased over time?:A systematic review显示文摘 | Phua J Badia JR Adhikari NK | | 0，，03： | 1 |
| 18 | Coupled tandem optical parametric oscillator (OPO): An OPO within an OPO 显示文摘 | LAI K S WU R F | 1998 | Opt Lett1998，23，16： | 1 |
| 19 | The Role of Maternal Serum Biomarkers in the Early Diagnosis of Ectopic Pregnancy显示文摘 | Phua C Reid S Condous G | 2015 | Current Chem Biol2015，8，2： | 1 |
| 20 | Parallel nonlinear optimization techniques for training neural networks 显示文摘 | PHUA P H MING D H | 2003 | IEEE Transactions on Neural Networks2003，14，6： | 1 |
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