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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 4 | Microtubules mobility affects themodulation of L-type ICa by muscarinic and β-adrenergic agonists in guinea-pig cardiac myocytes显示文摘 | Malan D PIa Gallo M Bedendi I | 2003 | J Mol Cell Cardiol2003，35，： | 1 |
| 5 | Cerebrospianl fluid β-Amyloid(1-42) in Alzheimer disease显示文摘 | Niels A Camilla H Pia D | 1999 | Arch Neurol1999，56，： | 1 |
| 6 | Comparison of different depletion strategies for improved resolution in proteonfic analysis of human serum samples显示文摘 | Karin B Tasso M Pia D | 2004 | Proteomics2004，4，： | 1 |
| 7 | A variable neighborhood descent algo- rithm for a real waste collection problem with mobile depots 显示文摘 | Pia D A Filippi C | 2006 | Int Trans Oper Res2006，13，： | 1 |
| 8 | Amyloid in bone marrow smears of patients affected by multiple myeloma显示文摘 | Fara Petruzziello Pio Zeppa Lucio Catalano Immacolata Cozzolino Giuseppe Gargiulo Pellegrino Musto Fiorella D’Auria Vincenzo Liso Rita Rizzi Nadia Caruso Catello Califano Eugenio Piro Maurizio Musso Vincenza Bonanno Antonietta Pia Falcone Salvatore Tafuto | 2010 | Annals of Hematology2010，，5： | 1 |
| 9 | Cytokines and chemokines are both expressed by human myoblasts:possible relevance for the immune pathogenesis of muscle inflammation显示文摘 | ROSSI M D PIA BERNASCONI P BAGGI F | 2000 | Int Immunol2000，12，9： | 1 |
| 10 | Switchable ionic liquid ( SILs ) based on glycerol and acid gases 显示文摘 | Ikenna A Pasi V Pia D | 2011 | RSC Ad- vances2011，1，： | 1 |
| 11 | The Role of Centralized Reading of Endoscopy in a Randomized Controlled Trial of Mesalamine for Ulcerative Colitis显示文摘 | Brian G. Feagan William J. Sandborn Geert D'Haens Suresh Pola John W.D. McDonald Paul Rutgeerts Pia Munkholm Ulrich Mittmann Debra King Cindy J. Wong Guangyong Zou Allan Donner Lisa M. Shackelton Denise Gilgen Sigrid Nelson Margaret K. Vandervoort Mariann | 2013 | Gastroenterology2013，，1： | 1 |
| 12 | The Role of Centralized Reading of Endoscopy in a Randomized Controlled Trial of Mesalamine for Ulcerative Colitis显示文摘 | Brian G. Feagan William J. Sandborn Geert D’Haens Suresh Pola John W.D. McDonald Paul Rutgeerts Pia Munkholm Ulrich Mittmann Debra King Cindy J. Wong Guangyong Zou Allan Donner Lisa M. Shackelton Denise Gilgen Sigrid Nelson Margaret K. Vandervoort Mariann | 2013 | Gastroenterology2013，，1： | 1 |
| 13 | Effects of modified nutrient concentrations and ratios on the structure and function of the native phytoplankton community in the Neuse River Estuary,North Carolina,USA显示文摘 | MICHAEL F P JULIANNE D PIA H M | 2002 | Aquatic Ecology2002，36，： | 1 |
| 14 | The Cekl and Hog1 mitogen activated protein kinase play complementary roles in cell wall biogenesis and ehlamydospore formation in the fungal pathogen Candida albicans显示文摘 | Eisman B Monge R A Roman E Arana D M Nombela C PIa J | 2006 | Eoukar ot Cell2006，5，： | 1 |
| 15 | Flowering phenology and pollen-to-ovule ratio in coastal dune communities near Eurosiberian-Mediterranean border in the NW Iberian peninsula显示文摘 | Pias B Guiti d n P | 2001 | Flora2001，196，： | 1 |
| 16 | Cerebrospianl fluid β-Amyloid (1-42) in Alzheimer disease 显示文摘 | NielsA Camilla H Pia D | 1999 | Arch Neurd1999，56，： | 1 |
| 17 | The Unexpected Movement of the HIV Epidemic in the Southeastern United States: Transmission Among College Students显示文摘 | Lisa B Hightow Pia D. M MacDonald Christopher D Pilcher Andrew H Kaplan Evelyn Foust Trang Q Nguyen Peter A Leone | 2005 | JAIDS Journal of Acquired Immune Deficiency Syndromes2005，，5： | 1 |
| 18 | Recent developments in mo lecular genetics of Candida albicans 显示文摘 | De Backer M D Magee P T PIa J | 2000 | Ann Rev Microbiol2000，54，： | 1 |
| 19 | The Effects of early rapid control of multiple bowel perforations after high-energy trauma to the abdomen:implications for damage control surgery显示文摘 | Pia Olosson M D Fikri M Abu-zidan M D | 2006 | J Trauma2006，61，1： | 1 |
| 20 | 7 - year survey after percutaneous dilatational tracheoto- my on a medical intensive care unit显示文摘 | Pia Lebiedz M D Annemarie Suca M D Emel Gumus M D | 2010 | Journal of investigative medicine2010，8，58： | 1 |
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