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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 3 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 4 | 7-year survey after percutaneous dilatational tracheotomy on a medical intensive care unit显示文摘 | PIA L ANNEMARIE S EMEL G | 2010 | J Investigat Med2010，58，8： | 1 |
| 5 | Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma显示文摘 | Bovio S Pia A | 2005 | Eur J of Endo2005，153，： | 1 |
| 6 | Nitrogen regulation of root branching显示文摘 | Pia W L Igor I Ivanov S F | 2006 | Annals of Botany2006，97，5： | 1 |
| 7 | Study of preozonation influence on the physical-chemical treatment of textile wastewater显示文摘 | S Barredo Damas M I Iborra Clar A Bes Pia | 2005 | Desalination2005，182，： | 1 |
| 8 | Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet,ultrasonic,and vibrating-mesh nebulizers显示文摘 | Moritz BB Pia K Thomas S | 2012 | Eur J Pharm Biopharm2012，82，2： | 1 |
| 9 | Thioredoxin reduc?tase: a target for gold compounds acting as potential anti?cancer drugs 显示文摘 | Alberto B Pia R M Guido S | 2009 | Coord Chem Rev2009，253，1112： | 1 |
| 10 | Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation(C-reactive protein,interleukin-6,soluble adhesion molecules,von willebrand factor,and endothelin-1)显示文摘 | Maria JE Angela S | 2003 | J Am Cardiol2003，91，： | 1 |
| 11 | Laser-induced breakdown-detection for reliable online monitoring of membrane integrity 显示文摘 | Martin T Pia L Frank S | 2014 | J Membr Sei2014，466，： | 1 |
| 12 | Human alphaltype Ⅳ collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alphal betal integrin 显示文摘 | Akulapalli S Pia N Venkateshwar GK | 2005 | Clin Invest2005，115，10： | 1 |
| 13 | The relationship between sleep and epilepsy:the effect oncognitive functioning in children显示文摘 | Parisi P Bruni O Pia Villa M Verrotti A Miano S Luchetti A | 2010 | Dev Med Child Neurol2010，52，9： | 1 |
| 14 | The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation 显示文摘 | Pias S Peterson TA Johnson DL | 2010 | Cfit Rev Immunol2010，30，3： | 1 |
| 15 | A DNA methylation prognostic signature of glioblastoma:identification of NPTX2-PTEN- NF-KB nexus显示文摘 | Shukla S Pia Patric IR Thinagararjan S | 2013 | Caneer Res2013，73，22： | 1 |
| 16 | An improved HPLC-ICPMS method for determination inorganic arsenic in food: application to rice, wheat and tuna fish 显示文摘 | Georg R Natascha S Pia H | 2012 | Food Chemistry2012，，134： | 1 |
| 17 | Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention显示文摘 | Jeffrey S Davies Pia Kotokorpi Sinan R Eccles | | 0，，06： | 1 |
| 18 | Targeted deletion of Clql TNF-related protein 9 increases food intake,decreases in?sulin sensitivity ,and promotes hepatic steatosis in mice显示文摘 | Zhikui W Xia L Pia S | 2014 | AmJ Physiol Endocrinol Metah2014，306，7： | 1 |
| 19 | Characterization of a Highly Evolved Vaeeine-Derived Poliovirus Type 3 Isolated from Sewage in Estonia 显示文摘 | Soile B Carita S Pia L | 2004 | J Virol2004，78，9： | 1 |
| 20 | Subclinical Cushing' s syndrome显示文摘 | Terzolo M Bovio S Pia A | 2007 | Arq Bras Endocrinol Metabol2007，51，11： | 1 |
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