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| 1 | Transcriptome reprogramming,epigenetic modifications and alternative splicing orchestrate the tomato root response to the beneficial fungus Trichoderma harzianum显示文摘Beneficial interactions of rhizosphere microorganisms are widely exploited for plant biofertilization and mitigation of biotic and abiotic constraints.To provide new insights into the onset of the roots–beneficial microorganisms interplay,we characterised the transcriptomes expressed in tomato roots at 24,48 and 72 h post inoculation with the beneficial fungus Trichoderma harzianum T22 and analysed the epigenetic and post-trascriptional regulation mechanisms.We detected 1243 tomato transcripts that were differentially expressed between Trichoderma-interacting and control roots and 83 T.harzianum transcripts that were differentially expressed between the three experimental time points.Interaction with Trichoderma triggered a transcriptional response mainly ascribable to signal recognition and transduction,stress response,transcriptional regulation and transport.In tomato roots,salicylic acid,and not jasmonate,appears to have a prominent role in orchestrating the interplay with this beneficial strain.Differential regulation of many nutrient transporter genes indicated a strong effect on plant nutrition processes,which,together with the possible modifications in root architecture triggered by ethylene/indole-3-acetic acid signalling at 72 h post inoculation may concur to the well-described growth-promotion ability of this strain.Alongside,T.harzianum-induced defence priming and stress tolerance may be mediated by the induction of reactive oxygen species,detoxification and defence genes.A deeper insight into gene expression and regulation control provided first evidences for the involvement of cytosine methylation and alternative splicing mechanisms in the plant–Trichoderma interaction.A model is proposed that integrates the plant transcriptomic responses in the roots,where interaction between the plant and beneficial rhizosphere microorganisms occurs. | Monica De Palma Maria Salzano Clizia Villano Riccardo Aversano Matteo Lorito Michelina Ruocco Teresa Docimo Anna Lisa Piccinelli Nunzio D’Agostino Marina Tucci | 2019 | Horticulture Research2019，6，1： | 2 |
| 2 | Macular thickness measured by optical coherence tomograpby in a healthy population before and after uncomplicated cataract phacoemulsification surgery显示文摘 | Cagini C Fiore T Iaccheri B Piccinelli F Ricci MA Fruttini D | 2009 | Current Eye Resereh2009，34，12： | 1 |
| 3 | A framework for geomet- ric analysis of vascular structures: application to cerebral aneurysms显示文摘 | Piccinelli M Veneziani A Steinman D A | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 4 | Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity 显示文摘 | JULIAO L D S PICCINELLI A L MARZOCCO S | 2009 | J Nat Prod2009，72，8： | 1 |
| 5 | Macular thickness measured by optical coherence tomography in a healthy population before and after uncomplicated cataract phacoemulsification surgery显示文摘 | Cagini C Fiore T Iaccheri B Piccinelli F Ricci MA Fruttini D | 2009 | Curr Eye Res2009，34，12： | 1 |
| 6 | Dynamic service aggregation in electronic marketplaces显示文摘 | PICCINELLI G VITANTONIO G D MOKRUSHIN L | 2001 | Computer Networks2001，37，： | 1 |
| 7 | Submucosal reconstructive hem- orrhoidectomy( Parks' operation) :a 20-year experience 显示文摘 | Rosa G Lolli P Piccinelli D | 2005 | Tech Coloprocto12005，9，3： | 1 |
| 8 | Rethinking hospital psychiatry in Italy in light of COVID-19 experience显示文摘BACKGROUND Italy retains a distinctive organization of mental health services according to a community-based model of care with a multidisciplinary team serving a welldefined catchment area under the coordination of the local department of mental health.The coronavirus disease 2019(COVID-19)pandemic is forcing Italian mental health services to develop new organizational strategies at all levels of care in order to face the associated challenges.AIM To explore factors associated with changes in psychiatric admissions to an inpatient psychiatric unit located in Lombardia Region,Italy.METHODS All hospital admissions(n=44)were recorded to an inpatient psychiatric unit during a three month national lockdown in Italy in 2020 and compared with those occurring over the same time period in 2019(n=71).For each admission,a 20-item checklist was completed to identify factors leading to admission.Statistical analyses were performed using Statistical Package for Social Sciences for Windows,release 11.0.Chi-square test(or Fisher’s exact test)and Mann-Whitney U-test were applied,where appropriate.RESULTS Hospital admissions dropped by 38%during the COVID-19 pandemic.No significant differences were found in demographics,clinical variables associated with hospital admissions and length of stay between 2019 and 2020.Compared with 2019,a significantly greater proportion of hospital admissions in 2020 were related to difficulties in organizing care programs outside the hospital(chi-square=4.91,df 1,one-way P=0.035)and in patients’family contexts(chi-square=3.71,df 1,one-way P=0.049).On the other hand,logistic and communication difficulties pertaining to residential facilities and programs were significantly more common in 2019 than in 2020(chi-square=4.38,df 1,one-way P=0.032).CONCLUSION Admissions to the inpatient psychiatric unit dropped significantly during the COVID-19 pandemic in 2020,with difficulties in organizing care programs outside the hospital and in patients’family contexts occurring more frequently compared with 2019. | Marco P Piccinelli Paola Bortolaso Greg D Wilkinson | 2022 | World Journal of Virology2022，11，1： | 0 |
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