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| 1 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 2 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 3 | Combined therapeutic approach:Inflammatory bowel diseases and peripheral or axial arthritis显示文摘Inflammatory bowel diseases(IBDs), particularly Crohn's disease(CD) and ulcerative colitis(UC), are associated with a variety of extra-intestinal manifestations(EIMs).About 36% of IBD patients have at least one EIM, which most frequently affect the joints, skin, eyes and the biliary tract.The EIMs associated with IBD have a negative impact on patients with UC and CD, and the resolution of most of them parallels that of the active IBD in terms of timing and required therapy;however, the clinical course of EIMs such as axial arthritis, pyoderma gangrenosum, uveitis, and primary sclerosing cholangitis is independent of IBD activity.The peripheral and axial arthritis associated with IBD have traditionally been treated with simple analgesics, non-steroidal anti-inflammatory drugs, steroids, sulfasalazine, methotrexate, local steroid injections and physiotherapy, but the introduction of biological response modifi ers such as tumor necrosis factor-α blockers, has led to further improvements. | Fabiola Atzeni Sandro Ardizzone Luca Bertani Marco Antivalle Alberto Batticciotto Piercarlo Sarzi-Puttini | 2009 | World Journal of Gastroenterology2009，15，20： | 2 |
| 4 | Osteoarthritis: An Overview of the Disease and Its Treatment Strategies显示文摘 | Piercarlo Sarzi-Puttini Marco A. Cimmino Raffaele Scarpa Roberto Caporali Fabio Parazzini Augusto Zaninelli Fabiola Atzeni Bianca Canesi | 2005 | Seminars in Arthritis and Rheumatism2005，，1： | 2 |
| 5 | New materials for polymer electrolytes 显示文摘 | PIERCARLO M ELIANA Q CORRADO T | 2000 | Solid State Ionics2000，135，： | 1 |
| 6 | Efficacy and Safety of Anti-Tumour Necrosis Factor in Elderly Patients with Rheumatoid Arthritis: An Observational Study显示文摘 | Matteo Filippini Chiara Bazzani Ennio Giulio Favalli Antonio Marchesoni Fabiola Atzeni Piercarlo Sarzi-Puttini Francesca Bobbio Pallavicini Roberto Caporali Roberto Gorla | 2010 | Clinical Reviews in Allergy & Immunology2010，，： | 1 |
| 7 | Potential Value of Contrast-Enhanced Intraoperative Ultrasonography During Partial Hepatectomy for Metastases: An Essential Investigation Before Resection?显示文摘 | Edward Leen Piercarlo Ceccotti Susan J. Moug Paul Glen John MacQuarrie Wilson J. Angerson Thomas Albrecht Joachim Hohmann Anja Oldenburg Jorg Peter Ritz Paul G. Horgan | 2006 | Annals of Surgery2006，，2： | 1 |
| 8 | Impact of diabetes and hy- pertension on left ventricular longitudinal systolic function显示文摘 | Piercarlo B Matteo C Sergio M | 2010 | Di- abetes Research and Clinical Practice2010，90，9： | 1 |
| 9 | Rheumatic manifestations in inflammatory bowel disease显示文摘 | Fabiola Atzeni Caterina Defendenti Maria Chiara Ditto Alberto Batticciotto Donatella Ventura Marco Antivalle Sandro Ardizzone Piercarlo Sarzi-Puttini | 2013 | Autoimmunity Reviews2013，，： | 1 |
| 10 | Metastatic colorectal cancer显示文摘 | Piercarlo Saletti Franco Cavalli | 2006 | Cancer Treatment Reviews2006，，7： | 1 |
| 11 | Effects of two target-con-trolled concentrations (1 and 3ng/mL) of remifentanll on MAC of sevoflurance显示文摘 | Andrea A Andrea C Piercarlo B | 2004 | Anesthesiology2004，100，2： | 1 |
| 12 | Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis显示文摘 | Piercarlo SP Tania F Benedetta P | 2002 | BMC Musculoskeletal Disorders2002，3，1： | 1 |
| 13 | Role of Agents other than Tumor Necrosis Factor Blockers in the Treatment of Psoriatic Arthritis显示文摘 | Atzeni Fabiola Costa Luisa Caso Francesco Scarpa Raffaele Sarzi-Puttini Piercarlo | 2015 | The Journal of Rheumatology Supplement2015，，0： | 1 |
| 14 | Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: Comparison of adalimumab, etanercept and infliximab in the GISEA registry显示文摘 | Fabiola Atzeni Piercarlo Sarzi-Puttini Costantino Botsios Antonio Carletto Paola Cipriani Ennio Giulio Favalli Elena Frati Valentina Foschi Stefania Gasparini AnnaRita Giardina Elisa Gremese Florenzo Iannone Marco Sebastiani Tamara Ziglioli Domenico Biasi | 2012 | Autoimmunity Reviews2012，，2： | 1 |
| 15 | A Parametric Study of Curved Incrementally Launched Bridges显示文摘 | Michele Fabio Granata Piercarlo Margiotta Marcel- 1o Arici | 2013 | Engineering Structures2013，49，： | 1 |
| 16 | A Parametric Study of Curved Incrementally Launched Bridges显示文摘 | Michele Fabio Granata Piercarlo Margiotta Marcello Ariel | 2013 | Engineering Structures2013，，49： | 1 |
| 17 | Effects of two target-controlled concentration ( 1 and 3 ng· mL^- 1) of remifentanil on MACBAR of sevoflurance 显示文摘 | ANDREA A ANDREA C PIERCARLO B | 2004 | Anesthesiology2004，100，2： | 1 |
| 18 | Solid State Ionics显示文摘 | Eliana Q Piercarlo M Aldo M | 1998 | 110:11998，110，： | 1 |
| 19 | QT interval duration in apparently healthy men is associated with depression-related personality trait neuroticism显示文摘 | Piercarlo Minoretti Pierluigi Politi Valentina Martinelli Enzo Emanuele Marco Bertona Colomba Falcone Diego Geroldi | 2006 | Journal of Psychosomatic Research2006，，1： | 1 |
| 20 | Left Ventricular Systolic Longitudinal Function: Comparison Among Simple M-Mode, Pulsed, and M-Mode Color Tissue Doppler of Mitral Annulus in Healthy Individuals显示文摘 | Sergio Mondillo Maurizio Galderisi Piercarlo Ballo Paolo Nicola Marino | 2006 | Journal of the American Society of Echocardiography2006，，9： | 1 |
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