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| 1 | Benign retroperitoneal schwannoma presenting as colitis:A case report显示文摘We report a case of a patient presenting with clinical,radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed,which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures,which leads to a wide spectrum of non-specific symptoms,including lumbar pain,headache,secondary hypertension,abdominal pain and renal colicky pain. CT and MR findings show characteristic features,but none are specific. Schwannoma can be isolated sporadic lesions,or associated with schwannomatosis or neurofibromatosis type Ⅱ (NF2). Although they vary in biological and clinical behavior,their presence is,in nearly every case,due to alterations or absence of the NF2 gene,which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma. | Gary Fass Didier Hossey Michel Nyst Dirk Smets Esmail Najar Saligheh Ruth Duttmann Kathleen Claes Pierre Mendes da Costa | 2007 | World Journal of Gastroenterology2007，13，41： | 5 |
| 2 | 口服非洲刺李后人的血清对不同良性前列腺细胞的生物效应显示文摘非洲刺李(太得恩。)是一种普遍用于治疗有症状良性前列腺增生的草药。该药物的活性物质还没有被鉴定出来,因此,确定其血药浓度是不可能的。对该药的疗效目前存在一些争议,因而我们决定用摄入和未摄入非洲刺李的人的血清在体外处理前列腺细胞,观察其对前列腺细胞生长的作用。我们使用的是原代培养和器官培养的良性成纤维(WPMY)前列腺细胞和上皮(PNT2)前列腺细胞。我们也使用了新鲜的良性前列腺组织。研究发现,摄入非洲刺李的人血清可以减少原代培养细胞、器官培养细胞以及WPMY细胞的增殖,但不影响PNT2细胞的增殖。我们还利用AffymetrixHG.U1332.0PLUS芯片分析了处理血清对WPMY细胞基因表达的影响。转录子分析结果显示参与肿瘤抑制通路的多个基因的表达发生了上调,而一些参与炎症及氧化应激通路的基因表达发生了下调。口服非洲刺李可使药物的活性物质达到足够的血清水平,从而抑制成纤维前列腺细胞的增殖。此抑制作用与转录子的改变有关。 | Stephane Larre Philippe Camparo Eva Comperat Delphine Boulbes Mohammed Haddoum Sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot | 2012 | Asian Journal of Andrology2012，14，3： | 2 |
| 3 | Chemical and microbiological characterization of tinctures and microcapsules loaded with Brazilian red propolis extract显示文摘The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers(isoflavonoids, chalcones, pterocarpans,flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions(A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i. e.spray-drying and freeze-drying to obtain microcapsules loaded with the red propolis extract. The tinctures and microcapsules of the red propolis were submitted to the total flavonoid content and antioxidant activity tests.The antibacterial activity and minimum inhibitory concentration(MIC) were tested using Staphylococcus aureus ATCC 25293 and Pseudomonas aeruginosa ATCC 27853 strains. The tinctures and microcapsules presented high flavonoid quantities from 20.50 to 40.79 mg/100 mg of the microcapsules. The antioxidant activity and IC50 were determined for the tinctures A and B(IC50: 6.95 μg/m L and 7.48 μg/m L), the spray-dried microcapsules(IC50: 8.89–15.63 μg/m L) and the freeze-dried microcapsules(IC50: 11.83–23.36 μg/m L). The tinctures and microcapsules were proved to be bioactive against gram-positive and gram-negative bacteria with inhibition halos superior to 10 mm at concentration of 200 μg/m L and MIC values of 135.87–271.74 μg/m L using gram-positive strain and 271.74–543.48 μg/m L using gram-negative strain. The tinctures and microcapsules of the red propolis have a potential application for nutraceutical products. | Erika Tayse da Cruz Almeida Maria Cristina Delgado da Silva José Marcos dos Santos Oliveira Regianne Umeko Kamiya Rodolfo Elleson dos Santos Arruda Danilo Abreu Vieira Valdemir da Costa Silva Pierre Barnabé Escodro Irinaldo Diniz Basílio-Júnior Ticiano Gomes do Nascimento | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 2 |
| 4 | Insecticide resistance status of the codling moth Cydia pomonella (Lepidoptera: Tortricidae) from Greece显示文摘 | Costas Ch. Voudouris Benoit Sauphanor Pierre Franck Maritza Reyes Zissis Mamuris John A. Tsitsipis John Vontas John T. Margaritopoulos | 2011 | Pesticide Biochemistry and Physiology2011，，3： | 1 |
| 5 | Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial显示文摘 | Christophe Vinsonneau Christophe Camus Alain Combes Marie Alyette Costa de Beauregard Kada Klouche Thierry Boulain Jean-Louis Pallot Jean-Daniel Chiche Pierre Taupin Paul Landais Jean-Fran?ois Dhainaut | 2006 | The Lancet2006，，9533： | 1 |
| 6 | cGMP signalling in pre-and post-conditioning: the role of mitochondria显示文摘 | COSTA AD PIERRE SV COHEN MV | 2008 | Card- iovasc Res2008，77，2： | 1 |
| 7 | Cardioprotective signaling to mitochondria显示文摘 | Keith D. Garlid Alexandre D.T. Costa Casey L. Quinlan Sandrine V. Pierre Pierre Dos Santos | 2008 | Journal of Molecular and Cellular Cardiology2008，，6： | 1 |
| 8 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 9 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 10 | Alternative oxidase regulation in roots of Vigna unguiculata cultivars differing in drought/salt tolerance显示文摘 | José Hélio Costa Yves Jolivet Marie-Paule Hasenfratz-Sauder Elena Graciela Orellano Maria da Guia Silva Lima Pierre Dizengremel Dirce Fernandes de Melo | 2006 | Journal of Plant Physiology2006，，6： | 1 |
| 11 | Morphology and fractal dimension of root systems of maize hybrids bearing the leafy trait 显示文摘 | Costa C Lianne M D Pierre D | 2003 | Canadian Journal of Botany2003，81，7： | 1 |
| 12 | Interrelationships of applied nitrogen ,SPAD,and yield of leafy and non-leafy maize genotypes显示文摘 | Carlos Costa Lianne M D Pierre Dutilleul | 2001 | Journal of Plant Nutrition2001，24，8： | 1 |
| 13 | cGMP signaling in pre-and post-conditioining: the role of mitochondria 显示文摘 | Costa AD Pierre SV Cohen MV | 2008 | Cardiovasc Res2008，77，2： | 1 |
| 14 | The safety of the inside-out transobturator approach for transvaginal tape (TVT-O) treatment in stress urinary incontinence: French registry data on 984 women显示文摘 | Pierre Collinet Calin Ciofu Pierre Costa Michel Cosson Bruno Deval Philippe Grise Bernard Jacquetin Francois Haab | 2008 | International Urogynecology Journal2008，，5： | 1 |
| 15 | Liposomal systems as drug delivery vehicles for dermal and transdermal applications 显示文摘 | Pierre M Costa I | 2011 | Arch Dermatol Res2011，303，： | 1 |
| 16 | Liposomal systems as drug delivery vehicles for dermal and transdermal applications 显示文摘 | Pierre M B Dos Santos Miranda Costa I | 2011 | Arch Dermatol Res2011，303，9： | 1 |
| 17 | Effect of bisphosphonates on pain andquality of life in patient with bom metastases 显示文摘 | Pierre P Major Luis Costa | 2009 | Nature ClinicalPractice Oncology2009，，： | 1 |
| 18 | cGMP signalling in pre-and post-conditioning:the role of mitochondria显示文摘 | Costa ADT Pierre SV Cohen MV | | 0，，： | 1 |
| 19 | cGMP signalling in pre- and post-conditioning: the role of mitochondria显示文摘 | Costa A D Pierre S V Cohen M V | 2008 | Cordio- vasc Res2008，77，2： | 1 |
| 20 | A150: Control of Cell Proliferation in Lupus Nephritis: The Role of miRNAs and HER2 显示文摘 | Aria Patr'tcia Costa Reis Stefania Gallucci Pierre gusso | 2014 | Am Coll Rheumatol2014，66，53： | 1 |
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