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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Surface plasmon resonance imaging (SPRi) as an alternative technique for rapid and quantitative screening of small molecules, useful in drug discovery 显示文摘 | PILLET F ROMERA C TR6VISIOL E | 2011 | Sensors and Ac- tuators B: Chemical2011，157，1： | 1 |
| 3 | Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，： | 1 |
| 4 | Serum antimullerianhormone levels remain stable throughout the menstrual cy-cle and after oral or vaginal administration of synthetic sexsteroids显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，2： | 1 |
| 5 | Management of cytomegalovirus infection in inflammatory bowel diseases显示文摘 | Pillet S Pozzetto B Jarlot C | 2012 | Dig Liver Dis2012，44，7： | 1 |
| 6 | Serum anti-Mtillerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids 显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，： | 1 |
| 7 | Serum anti-Müllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids显示文摘 | Streuli I Fraisse T Pillet C | | 0，，02： | 1 |
| 8 | Serum antiMfillerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids 显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，： | 1 |
| 9 | Serum antimüllerian hormonelevels remain stable throughout the menstrual cycle and after oral orvaginal administration of synthetic sex steroids显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，2： | 1 |
| 10 | Comparative evaluation of the VIDAS HIV DUO Ultra assay for combined detection of HIV-1 antigen and antibodies to HIV显示文摘 | Bourlet T Pretis C Pillet S | 2005 | JVirolMethods2005，127，2： | 1 |
| 11 | Monitoring HCMV infection with quantitative real-time PCR in HCMV-positive orthotopic liver transplant recipients,and predictive factors for treatment of the first episode of HCMV viremia显示文摘 | Pillet A Mengelle C Basse G | | 0，，07： | 1 |
| 12 | Atomic Force Microscopy and pharmacology : From microbiology to can- cerology 显示文摘 | PILLET F CHOPINET L FORMOSA C | 2014 | Biochimiea et Biophysica Acta (BBA) -General Subjects2014，1840，3： | 1 |
| 13 | Inside-outside duality for planar billiards:numerical study 显示文摘 | DIETZ B ECKMANN J P PILLET C A | 1995 | Phys Rev E1995，51，： | 1 |
| 14 | Serum antimiillerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids 显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，： | 1 |
| 15 | Observation of Near-infrared Dicke Superradiance on Cascading Transitions in Atomic Sodium显示文摘 | GROSS M FABRE C PILLET P | 1976 | Phys Rev Lett1976，36，： | 1 |
| 16 | Atomic Force Microscopy and pharmacology: From microbiology to cancerology显示文摘 | Flavien Pillet Louise Chopinet Cécile Formosa étienne Dague | 2014 | BBA - General Subjects2014，，3： | 1 |
| 17 | Serum antimtillerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids 显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，2： | 1 |
| 18 | A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy显示文摘 | Kadefli S Boulocher C Pillet E | 2015 | Int J Pharm2015，483，12： | 1 |
| 19 | 显示文摘 | KIM C D PILLET S WU G | 2002 | Acta Cryst2002，58，： | 1 |
| 20 | On the magnetic field strength of active region filaments 显示文摘 | Kuckein C Centeno R Martinez Pillet V | 2009 | KCMCMS2009，，4： | 1 |
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