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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，： | 1 |
| 3 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel D R | 2004 | Circ Res2004，94，： | 1 |
| 4 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，： | 1 |
| 5 | Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus显示文摘 | Mehta D Pimentel DA Núez MZ | 2014 | Metabolism2014，25，14： | 1 |
| 6 | Gaussian processes for personalized e-health monitoring with wearable sensors 显示文摘 | Clifton L Clifton DA Pimentel M | 2013 | IEEE Trans Biomed Eng2013，60，1： | 1 |
| 7 | Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras显示文摘 | Kuster GM Pimentel DR Adachi T Ido Y Brenner DA Cohen RA | 2005 | Circulation2005，111，： | 1 |
| 8 | Effects of drought on O2 evolution and stomatal conductance of beans at the pollination stage显示文摘 | Pimentel C Hebert G da Silva J V | 1999 | Environmental and Experimental Botany1999，42，： | 1 |
| 9 | Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus 显示文摘 | Mehta D Pimentel DA N~fiez MZ | 2014 | Metab2014，63，11： | 1 |
| 10 | Human amyloidogenic chains directly impair cardiomyoeyte function through all increase in cellular oxidant stress 显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，8： | 1 |
| 11 | L-Glutamate determination in food samples by flow-injection analysis 显示文摘 | Oliveira M1P Pimentel MC Montenegro MCBSM Araujo AN PimentelMF Silva VL da | 2001 | Anal Chim Acta2001，448，12： | 1 |
| 12 | Human amyloi- dogenic light chains directly impair cardiomyocyte func- tion through an increase in cellular oxidant stress显示文摘 | Brenner DA J ain M Pimentel DR | 2004 | Circ Res2004，94，8： | 1 |
| 13 | Human amyloidogeniclight chains directly impair cardiomyocyte function through anincrease in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，8： | 1 |
| 14 | Cellular localization of cadmium and structural changes in maize plants grown on a cadmium contaminated soil with and without liming显示文摘 | DA CUNHA K P V DO NASCIMENTO C W A DE MENDONCA PIMENTEL R M | 2008 | Journal of hazardous materials2008，160，1： | 1 |
| 15 | Establishment and conventional cytogenetic characterization of three gastric cancer cell lines显示文摘 | Mariana Ferreira Leal José Luiz Martins do Nascimento Carla Elvira Araújo da Silva Maria Fernanda Vita Lamar?o Danielle Queiroz Calcagno André Salim Khayat Paulo Pimentel Assump??o Isabel Rosa Cabral Marília de Arruda Cardoso Smith Rommel Rodríguez Burban | 2009 | Cancer Genetics and Cytogenetics2009，，1： | 1 |
| 16 | Role of reversible, thioredoxin-sensitive oxidative protein modifications in cardiac myocytes显示文摘 | Kuster GM Siwik DA Pimentel DR | 2006 | Antioxid Redox Signal2006，8，1112： | 1 |
| 17 | Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，： | 1 |
| 18 | Human amyloidogenic light chainsdirectly impair cardiomyocyte function through an increase in cellular oxidantstress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，8： | 1 |
| 19 | Curcumin in inflammatory bowel diseases:Cellular targets and molecular mechanisms显示文摘Curcumin,a natural product,has exhibited promising effects in both animal models and clinical trials,interacting with a multitude of factors linked to Inflammatory Bowel Disease(IBD).These factors encompass cytokines,oxidative stress-associated enzymes,and modulation of the intestinal microbiota.Notably,curcumin has demonstrated therapeutic potential in animal models of colitis,wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt,JAK/STAT,andβ-catenin.Moreover,it inhibits the expression of proinflammatory enzymes and co-stimulatory molecules(including RANKL,ICAM-1,CD205,CD256,TLR4,among others),while curbing immune cell chemotaxis,thereby attenuating the characteristic neutrophil infiltration observed in IBD.Another facet of curcumin’s action involves its modulation of the intestinal microbiota.Notably,the microbiota itself contributes to beneficial biotrans formations of curcumin,thereby enhancing its effectiveness in IBD treatment.On a clinical front,curcumin has demonstrated the ability to induce clinical and/or endoscopic remission without any reported toxic effects.Hence,curcumin warrants consideration as an adjunctive therapy in IBD management.Subsequent clinical investigations should concentrate on meticulously evaluating curcumin’s impact on these precise therapeutic targets. | AMYLLY SANUELLY DA PAZ MARTINS MARLA DE CERQUEIRA ALVES ORLANDO ROBERTO PIMENTEL DE ARAÚJO FABIANA OLIVEIRA DOS SANTOS CAMATARI MARÍLIA OLIVEIRA FONSECA GOULART FABIANA ANDRÉA MOURA | 2023 | BIOCELL2023，47，11： | 0 |
| 20 | Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression显示文摘Gastric cancer(GC)remains among the most common cancers worldwide with a high mortality-to-incidence ratio.Accumulated evidence suggests that long noncoding RNAs(lncRNAs)are involved in gastric carcinogenesis.These transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels,inducing or inhibiting biological processes and diseases.Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is one of the best-studied lncRNAs with comprehensive actions contributing to cancer progression.This lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and proteins.In the present review,we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in GC.Moreover,we highlighted the potential use of MALAT1 as a biomarker,including liquid biopsy. | Daniel Mateus de Oliveira Batista Jessica Manoelli Costa da Silva Carolina de Oliveira Gigek Marilia de Arruda Cardoso Smith Paulo Pimentel de Assumpcao Danielle Queiroz Calcagno | 2023 | World Journal of Gastrointestinal Oncology2023，15，9： | 0 |
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