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| 1 | Use of CardiacMarkers for Monitoring of Doxorubixininduced Cardiotoxicity inChildren with Cancer 显示文摘 | YUPADA P REKWAN S PIMLAK C | 2012 | Pediatr Hematol Oncol2012，34，8： | 1 |
| 2 | Significance of p53 Expression in Immature Teratomas显示文摘 | Pimlak Charoenkwan Christof Senger Sheila Weitzman Elizabeth Sexsmith Christopher G. Sherman David Malkin Paul S. Thorner | 2002 | Pediatric and Developmental Pathology2002，，5： | 1 |
| 3 | Wilms tumor with dilated cardiomyopathy: A case report显示文摘BACKGROUND Wilms tumor is the most common renal malignancy in childhood. It occurs primarily between the ages of 2 and 5 years. The usual manifestations are abdominal mass, hypertension, and hematuria. The case presented here had an unusual presentation, with dilated cardiomyopathy and hypertension secondary to the Wilms tumor. CASE SUMMARY A 3-year-old boy presented with a 5-d history of irritability, poor appetite, and respiratory distress. His presenting clinical symptoms were dyspnea, tachycardia, hypertension, and a palpable abdominal mass at the left upper quadrant. His troponin T and pro-B-type natriuretic peptide levels were elevated. Echocardiography demonstrated a dilated hypokinetic left ventricle with an ejection fraction of 29%, and a suspected left renal mass. Computed tomography scan revealed a left renal mass and multiple lung nodules. The definitive diagnosis of Wilms tumor was confirmed histologically. The patient was administered neoadjuvant chemotherapy and underwent radical nephrectomy. After surgery, radiotherapy was administered, and the adjuvant chemotherapy was continued. The blood pressure and left ventricular function normalized after the treatments. CONCLUSION Abdominal mass, dilated cardiomyopathy and hypertension can indicate Wilms tumor in pediatric patients. Chemotherapy and tumor removal achieve successful treatment. | Saviga Sethasathien Chane Choed-Amphai Kwannapas Saengsin Lalita Sathitsamitphong Pimlak Charoenkwan Kanokkan Tepmalai Suchaya Silvilairat | 2019 | World Journal of Clinical Oncology2019，10，8： | 0 |
| 4 | Warburg effect mimicking inborn errors of metabolism in childhood hematologic malignancies:A case-based systematic review显示文摘BACKGROUND Type B lactic acidosis and hypoglycemia can occur in various pediatric conditions.In young children with a history of fasting preceding these metabolic derangements,inborn errors of metabolism should be primarily considered.However,the Warburg effect,a rare metabolic complication,can also manifest in children with hematologic malignancies.Only a few reports of this condition in children have been published in the literature.AIM To identify the clinical course,treatment strategies,and outcomes of childhood hematologic malignancies with type B lactic acidosis.METHODS We performed a comprehensive search of the PubMed,Scopus,and Cochrane databases without any time restriction but limited to English language articles.The databases were last accessed on July 1st,2023.RESULTS A total of 20 publications were included in the analysis,all of which were case reports or case series.No higher quality evidence was available.Among children with hematologic malignancies and Warburg effect,there were 14 cases of acute lymphoblastic leukemia and 6 cases of non-Hodgkin’s lymphoma including our illustrative case.Lactic acidosis occurred in 55%of newly diagnosed cases and 45%of relapsed cases.The mean age was 10.3±4.5 years,and 80%of cases were male.The mean serum lactate was 16.9±12.6 mmol/L,and 43.8%of the cases had concomitant hypoglycemia.Lactic acidosis initially subsided in 80%of patients receiving chemotherapy compared to 60%in the contrast group.The mortality rate of newly diagnosed cases was 45.5%,while the relapsed cases represented a 100%mortality rate.All 8 patients reported before 2001 died from disease-related complications.However,patients described in reports published between 2003 and 2023 had a 54.5%rate of complete remission.CONCLUSION This complication has historically led to fatal outcome;however,patients who received chemotherapy showed a more favorable response.Therefore,it is crucial to promptly initiate specific treatment in this context. | Khanittha Permtawee Maliwan Tengsujaritkul Chane Choed-Amphai Supapitch Chanthong Kanittha Mankhemthong Lalita Sathitsamitphong Rungrote Natesirinilkul Pimlak Charoenkwan | 2023 | World Journal of Clinical Pediatrics2023，12，5： | 0 |
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