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| 1 | Influence of hepatitis viruses on clinico-pathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma显示文摘BACKGROUND: The global risk of hepatocellular carcinoma(HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. METHODS: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). RESULTS: The patients of both HBV (56.0±11.3 years) and HBCV groups (56.0±9.9 years) were significantly younger than those of the HCV (61.0±8.5 years, P=0.001) and non-BC groups(61.0±13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%)than in any other subsets (72%-90%, P<0.002). Furthermore, the non-BC patients were more advanced according to the Barcelona Clinic Liver Cancer stages than the patients of the HCV or HBCV groups (P<0.020); accordingly, they were more frequently assessed beyond the Milan criteria than any other groups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. CONCLUSIONS: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the longterm prognosis after surgical treatment in patients with HCC; however, there is a trend for worse disease-free survival rates in HBCV patients, though statistical significance was not reached. | Anna-Maria Tanase Traian Dumitrascu Simona Dima Razvan Grigorie Agnes Marchio Pascal Pineau Irinel Popescu | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 7 |
| 2 | 推进式食管-胃-十二指肠镜的病灶检出率依赖于隐匿性胃肠道出血的类型 | Lara L.F. Bloomfeld R.S. Pineau B.C. 尹勇 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 3 |
| 3 | Minerals,trace elementsand related biological variable in athletes and duringphysical activity显示文摘 | Specich M Pineau A Ballereau F | 2001 | Clin Chim Acta2001，312，12： | 1 |
| 4 | Towards a consistent mantle carbon flux estimate: Insights from volatile systematics (H2O/Ce, 8D, CO2/Nb) in the North Atlantic mantle显示文摘 | Cartigny P Pineau F Aubaucl C | 2008 | Earth and Planetary Science Letters2008，265，34： | 1 |
| 5 | Modelling the optimum grain size on the low cycle fatigue life ofa Ni based superalloy in the presence oftwo possible crack initiation sites 显示文摘 | Alexandre F Deyber S Pineau A | 2004 | Scripta materialia2004，50，1： | 1 |
| 6 | Influence of austenite predeforma-tion on mechanical properties and strain-induced martensitic transformations of a high manganese steel显示文摘 | Sipos K Remy L Pineau A | | 0，，05： | 1 |
| 7 | Modeling the optimum grain size on the low cycle fatigue life of a Ni-based superalloy in the presence of two possible crack initiation sites显示文摘 | Alexandre F Deyber S Pineau A | 2004 | Scripta Materialia2004，50，1： | 1 |
| 8 | Dynamic crack propagation and crack arrest investigated with a new specimen geometry: Part Ⅰ: Experimental and numerical calculations显示文摘 | Pineau | 1996 | Fatigue and Fracture of Engineering Materials and Structures1996，19，11： | 1 |
| 9 | Deformation and damagemechanisms of zinc coatings on hot-dip galvanized steel sheets显示文摘 | PARISOT R FOREST S PINEAU A | 2004 | Metallurgical and Materials Transactions2004，35，： | 1 |
| 10 | Physical and related sensory properties of a swallowable bolus显示文摘 | Loret C Walter M Pineau N | 2011 | Physiology and Behavior2011，104，5： | 1 |
| 11 | Twinning and strain-induced FCC→ HCP transformation in the Fe-Mn-Cr-C system显示文摘 | Remy L Pineau A | | 0，，01： | 1 |
| 12 | AGA future trends report: CT colonography显示文摘 | Jacques van Dam Peter Cotton C. Daniel Johnson Beth G. McFarland Benoit C. Pineau Dawn Provenzale David Ransohoff Douglas Rex Don Rockey F. Taylor Wootton | 2004 | Gastroenterology2004，，： | 1 |
| 13 | Biologic therapy andpregnancy outcomes in women with rheumatic diseases 显示文摘 | Vinet E Pineau C Gordon C | 2009 | Arthritis Care Res2009，61，5： | 1 |
| 14 | Food allergy to wheat:identification of immunoglobulin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour显示文摘 | BATFAIS F PINEAU F POPINEAU Y | | 0，，： | 1 |
| 15 | '3C/2C radios of rocks and inclusions in popping rocks of the mid-Atlantic ridge and their bearing on the problem of isotopic composition of deep- seated carbon显示文摘 | Pineau F Javory M Bottinga Y | | Earth and Planetary Science letters0，29，： | 1 |
| 16 | A Bayesian approach for learning and planning in partially observable Markov decision processes显示文摘 | Ross S Pineau J Chaib-draa B | 2011 | Journal of Machine Learning Research2011，12，： | 1 |
| 17 | Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients 显示文摘 | Marchio A Pineau P Meddeb M | 2000 | Oncogene2000，19，33： | 1 |
| 18 | Evaluation of unexplained acute and acute recurrent pancreatitis using endoscopic retrograde cholangiopancreatography, sphincter of Oddi manometry and endoscopic ultrasound 显示文摘 | Coyle WJ Pineau BC Tarnasky PR | 2002 | Endoscopy2002，34，8： | 1 |
| 19 | The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary 显示文摘 | Kimura S Hara Y Pineau T | 1996 | Genes Dev1996，10，1： | 1 |
| 20 | Proliferative actions of natriuretic peptides on neuroblastoma cells involvement of guanylyl cyclase and non-guanylyl cyclase pathways 显示文摘 | Leli eyre V Pineau N Hu Z | 2001 | J BioI Chern2001，276，43： | 1 |
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