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| 1 | Current and future pharmacological therapies for managing cirrhosis and its complications显示文摘Due to the restrictions of liver transplantation,complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis.This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications,together with discussion of current controversies and potential future directions.PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety,efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis.Non-selective betablockers effectively reduce variceal re-bleeding risk in cirrhotic patients with moderate/large varices,but appear ineffective for primary prevention of variceal development and may compromise renal function and haemodynamic stability in advanced decompensation.Recent observational studies suggest protective,haemodynamically-independent effects of beta-blockers relating to reduced bacterial translocation.The gut-selective antibiotic rifaximin is effective for secondary prophylaxis of hepatic encephalopathy;recent small trials also indicate its potential superiority to norfloxacin for secondary prevention of spontaneous bacterial peritonitis.Diuretics remain the mainstay of uncomplicated ascites treatment,and early trials suggest alpha-adrenergic receptor agonists may improve diuretic response in refractory ascites.Vaptans have not demonstrated clinical effectiveness in treating refractory ascites and may cause detrimental complications.Despite initial hepatotoxicity concerns,safety of statin administration has been demonstrated in compensated cirrhosis.Furthermore,statins are suggested to have protective effects upon fibrosis progression,decompensation and mortality.Evidence as to whether proton pump inhibitors cause gut-liver-brain axis dysfunction is conflicting.Emerging evidence indicates that anticoagulation therapy reduces incidence and increases recanalisation rates of non-malignant portal vein thrombosis,and may impede hepatic fibrogenesis and decompensation.Pharmacotherapy for cirrhosis should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management,nutritional optimisation and patient education. | David Kockerling Rooshi Nathwani Roberta Forlano Pinelopi Manousou Benjamin H Mullish Ameet Dhar | 2019 | World Journal of Gastroenterology2019，25，8： | 16 |
| 2 | Inotropes for the management of acute heart failure patients with renal dysfunction. Still an option?显示文摘 | Pinelopi Rafouli-Stergiou John T Parissis Maria Anastasiou-Nana | 2012 | Expert Opinion on Pharmacotherapy2012，，： | 1 |
| 3 | Goods prices and exchange rates: What have we learned? 显示文摘 | Goldberg Pinelopi and Michael Knetter | 1997 | Journal of Economic Literature1997，35，： | 1 |
| 4 | Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide显示文摘 | Costas Xidakis Dushanka Ljumovic Pinelopi Manousou George Notas Vassilis Valatas George Kolios Elias Kouroumalis | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
| 5 | Goods Prices and Exchange Rates:What have Welearned? 显示文摘 | Goldberg Pinelopi Michael Knetterl | 1997 | Journal of Economic Literature1997，，35： | 1 |
| 6 | Good prices and exchange rates: what have we learned 显示文摘 | Dberg Pinelopi Koujianou and Knetter Michael M | 1997 | Journal of Economic Literature1997，，35： | 1 |
| 7 | Trade reforms and wage inequality in Colombia 显示文摘 | ATI'ANASIO O PINELOPI G NINA P | 2004 | Journal of Development E- conomics2004，74，2： | 1 |
| 8 | Protection for Sale: An Empirical lnvestigation显示文摘 | Goldberg Pinelopi Koujianou and Maggi P | 1999 | The American Economic Review1999，89，5： | 1 |
| 9 | Collagen proportionate area is superior to other histological methods for sub-classifying cirrhosis and determining prognosis显示文摘 | Emmanuel Tsochatzis Sara Bruno Graziella Isgro Andrew Hall Eleni Theocharidou Pinelopi Manousou Amar P. Dhillon Andrew K. Burroughs Tu Vinh Luong | 2013 | Journal of Hepatology2013，，： | 1 |
| 10 | Trade Reforms and Income Inequality in Colombia 显示文摘 | Attanasio Orazio Pinelopi Goldberg and Nina Pavcnik | 2004 | Journal of Development Economics74:331-3662004，，： | 1 |
| 11 | Enteral nutrition af- fects nitric oxide poduction in peripheral blood and liver after a postoperative lipopolysaccharide-induced endotoxemia in rate显示文摘 | George K Katerina K Pinelopi M | 2007 | Nutrition2007，23，11： | 1 |
| 12 | Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation显示文摘 | Vincenza Calvaruso Amar Paul Dhillon Emanuel Tsochatzis Pinelopi Manousou Federica Grillo Giacomo Germani David Patch James O’Beirne Andrew Kenneth Burroughs | 2012 | Journal of Gastroenterology and Hepatology2012，，7： | 1 |
| 13 | Enteral nutrition affects nitric oxide production in peripheral blood and liver after a postoperative lipopolysaccharide - induced endotoxemia in rats 显示文摘 | George K Katerina K Pinelopi M | 2007 | Nutrition2007，23，： | 1 |
| 14 | Goods Prices and Exchange Rates: What Have We Leamed?显示文摘 | Goldberg Pinelopi and Michael Knetter | 1997 | Journal of Economic Literature1997，，35： | 1 |
| 15 | Genetic and molecular alterations in meningiomas显示文摘 | George A. Alexiou Sofia Markoula Pinelopi Gogou Athanasios P. Kyritsis | 2010 | Clinical Neurology and Neurosurgery2010，，4： | 1 |
| 16 | The occurrence of persistent chlorinated and brominated organic contaminants in the European eel ( Anguilla anguilla ) in Irish waters显示文摘 | Brendan McHugh Russell Poole John Corcoran Pinelopi Anninou Brian Boyle Eileen Joyce M. Barry Foley Evin McGovern | 2010 | Chemosphere2010，，3： | 1 |
| 17 | Imported interrmediate inputs and domestic product growth: evidence from india显示文摘 | GOLDBERG Pinelopi K AMIT Khandelwal NINA Pavcnik PETIA Topalova | 2010 | The quarterly journal of economics2010，125，4： | 1 |
| 18 | Protection for sale: an empirical investigation显示文摘 | Goldberg Pinelopi and Giovanni Maggi | 1999 | American Economic Review1999，89，5： | 1 |
| 19 | Trade reforms and wage inequality in Colombia显示文摘 | Orazio Attanasio Pinelopi K. Goldberg Nina Pavcnik | 2004 | Journal of Development Economics2004，，2： | 1 |
| 20 | Unusual case of massive hemorrhage of a gastric duplication cyst in a very advanced age显示文摘 | Serafeim Klimopoulos Dimitrios Gialvalis Meletios Marougas Dionysios Zotos Nikolaos Orfanos Antonios Roussakis Pinelopi Argyriou Catherine Pantelidaki | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
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