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| 1 | Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis:A single-center retrospective cohort study显示文摘AIM: To assess the efficiency and safety of radiofrequencyassisted hepatectomy in patients with hepatocellular carcinoma(HCC) and cirrhosis.METHODS: From January 2010 to December 2013, 179 patients with HCC and cirrhosis were recruited for this retrospective study. Of these, 100 patients who received radiofrequency-assisted hepatectomy(RF+ group) were compared to 79 patients who had hepatectomy without ablation(RF- group). The primary endpoint was intraoperative blood loss. The secondary endpoints included liver function, postoperative complications, mortality, and duration of hospital stay.RESULTS: The characteristics of the two groups were closely matched. The Pringle maneuver was not used in the RF+ group. There was significantly less median intraoperative blood loss in the RF+ group(300 vs 400 m L, P = 0.01). On postoperative days(POD) 1 and 5, median alanine aminotransferase was significantly higher in the RF+ group than in the RF- group(POD 1: 348.5 vs 245.5, P = 0.01; POD 5: 112 vs 82.5, P = 0.00), but there was no significant difference between the two groups on POD 3(260 vs 220, P = 0.24). The median AST was significantly higher in the RF+ group on POD 1(446 vs 268, P = 0.00), but there was no significant difference between the two groups on POD 3 and 5(POD 3: 129.5 vs 125, P = 0.65; POD 5: 52.5vs 50, P = 0.10). Overall, the rate of postoperative complications was roughly the same in these two groups(28.0% vs 17.7%, P = 0.11) except that post hepatectomy liver failure was far more common in the RF+ group than in the RF- group(6% vs 0%, P = 0.04).CONCLUSION: Radiofrequency-assisted hepatectomy can reduce intraoperative blood loss during liver resection effectively. However, this method should be used with caution in patients with concomitant cirrhosis because it may cause severe liver damage and liver failure. | Fan Zhang Jun Yan Xiao-Bin Feng Feng Xia Xiao-Wu Li Kuan-Sheng Ma Ping Bie | 2015 | World Journal of Gastroenterology2015，21，35： | 7 |
| 2 | A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma显示文摘 | Kai Feng Jun Yan Xiaowu Li Feng Xia Kuansheng Ma Shuguang Wang Ping Bie Jiahong Dong | 2012 | Journal of Hepatology2012，，4： | 5 |
| 3 | A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma显示文摘 | Kai Feng Jun Yan Xiaowu Li Feng Xia Kuansheng Ma Shuguang Wang Ping Bie Jiahong Dong | 2012 | Journal of Hepatology2012，，4： | 2 |
| 4 | First Total Synthesis of(±)—Abieta—8,11,13-trien-7β-ol显示文摘The first total synthesis of (?-abieta-8, 11, 13-trien-7?ol (7) was accomplished via a strategy of ACABC, in which the reduction of the ketone 6 with LiAlH4 gave exclusively the title compound. | Cheng Lu ZHANG Ping Yan BIE Xuan Jia PENG Yi YANG Xin Fu PAN | 2003 | Chinese Chemical Letters2003，14，5： | 1 |
| 5 | Total Synthesis of 16-Acetoxy-6,7-didehydroferruginyl Methyl Ether显示文摘An efficient synthetic route have been developed to 16-acetoxy-6,7-didehydroferruginyl methyl ether. | Yong Hong GAN An Pai LI Ping Yan BIE Xin Fu PAN (Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University.Lanzhou. 730000 ) | 2000 | Chinese Chemical Letters2000，11，6： | 0 |
| 6 | Total Synthesis of (±)-Celaphanol A显示文摘The first total synthesis of (?-Celaphanol A was accomplished starting from cyclocitral and 3,4-dimethoxy benzyl chloride via a six-step process, in which the intramolecular cyclization of ketone 4 with BF3稥t2O afforded an all-cis isomer intermediate for synthesis of aromatic tricyclic diterpenes. | Ping Yan BIE Cheng Lu ZHANG Xuan Jia PENG Xin Fu PAN | 2002 | Chinese Chemical Letters2002，13，9： | 0 |
| 7 | A clinical study on salvage hepatectomy for treating recurrent liver cancer after radiofrequency ablation显示文摘Objective We studied the efficacy of salvage hepatectomy for treating recurrent hepatic cancer after radiofrequency ablation(RFA). Methods A retrospective analysis of 67 patients who had recurrent liver cancer after RFA treatment and received salvage hepatectomy in the Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University(China), from January 2006 to January 2014, was performed. The analysis included patient gender, age, hepatitis type, alpha-fetoprotein(AFP), and TNM stage prior to RFA and salvage hepatectomy, overall survival rates, and tumor-free survival rates after salvage hepatectomy. Results Among the 67 patients, there were 57 cases of hepatitis B, two cases of hepatitis C, and eight cases did not have hepatitis. AFP levels in patients ranged from 3 to 4521 ng/m L(median 33 ng/m L). Before RFA, 54 cases were stage I tumors, and 13 were stage II tumors. Tumor sizes varied from 0.82 to 4.83 cm(median 3.0 cm). In 20 cases, one RFA was performed, and for 47 cases, RFA was repeated. RFAablated region diameters ranged from 3.8 to 5.2 cm(median 4.5 cm). The interval between the salvage surgical resection and RFA was 3–37 months. Before salvage hepatectomy, 23 stage I tumors, 12 stage II tumors, and 32 stage III tumors were present(size ranged 4.83–11.84 cm; median 6.3 cm). For salvage hepatectomy, laparotomy was performed for 56 cases, and laparoscopy was performed for 28 cases. Inflow clamping was performed for 39 cases(15–45 min). Surgery was 219–370 min and intraoperative blood loss was 100–2100 m L. For 13 cases, intraoperative blood transfusion was required. Tumor pathological data revealed 31, 35, and 1 poorly, moderately, and well differentiated tumors, respectively. No patients died due to operative complications, and hospital stays were 8–10 days. Overall and tumor-free survival rates were 85% and 79% for 1 year, 50% and 20% for 3 years, and 39% and 19% for 5 years, respectively. KaplanMeier analysis and Cox regression confirmed that tumor number and size prior to salvage liver cancer were risk factors affecting survival. Conclusion Patients who received RFA to treat early-stage liver cancer with postoperative recurrent stage I tumors have satisfactory outcomes with salvage hepatectomy. | Qing Xiong Xiaobin Feng Jun Yan Feng Xia Xiaowu Li Kuansheng Ma Ping Bie | 2015 | Oncology and Translational Medicine2015，1，6： | 0 |
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