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1篇 您的检索式：作者名="Pinhong Song"

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		题名	作者	年代	出处	被引量
	1	Clinical evidence of an interferon-glucocorticoid therapeutic synergy in COVID-19显示文摘Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system.In contrast,interferons are a crucial component of host antiviral immunity and can be directly suppressed by glucocorticoids.To investigate whether therapeutic interferons can compensate glucocorticoids-induced loss of antiviral immunity,we retrospectively analyzed a cohort of 387 PCR-confirmed COVID-19 patients with quasi-random exposure to interferons and conditional exposure to glucocorticoids.Among patients receiving glucocorticoids,early interferon therapy was associated with earlier hospital discharge(adjusted HR 1.68,95%Cl 1.19-2.37)and symptom relief(adjusted HR 1.48;95%Cl 1.06-2.08),while these associations were insignificant among glucocorticoids nonusers.Early interferon therapy was also associated with lower prevalence of prolonged viral shedding(adjusted OR 0.24,95%Cl 0.10-0.57)only among glucocorticoids users.Additionally,these associations were glucocorticoid cumulative dose-and timing-dependent.These findings reveal potential therapeutic synergy between interferons and glucocorticoids in COVID-19 that warrants further investigation.	Yingying Lu Feng Liu Gangling Tong Feng Qiu Pinhong Song Xiaolin Wang Xiafei Zou Deyun Wan Miao Cui Yunsheng Xu Zhihua Zheng Peng Hong	2021	Signal Transduction and Targeted Therapy2021，6，4：	0

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