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| 1 | Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls显示文摘 | Kumar-Singh S Pirici D McGowan E | 2005 | Am J Pathol2005，167，2： | 1 |
| 2 | VEGF and VEGFRs expression in oral squamous cell carcinoma显示文摘 | Margaritescu C Pirici D Simionescu C | 2009 | Rom J Morphol Embryol2009，50，4： | 1 |
| 3 | The utility ofCD44,CD117 and CD133 in identification of cancer stem cells(CSC)inoral squamous cell carcinomas(OSCC)显示文摘 | Mǎrgǎritescu C Pirici D Simionescu C | 2011 | Rom J MorpholEm-bryol2011，52，3： | 1 |
| 4 | Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer disease are centered on vessel walls 显示文摘 | Kumar Singh S Pirici D McGowan E | 2005 | Am J Pathol2005，167，2： | 1 |
| 5 | VEGF expression in human brain tissue after acute ischemic stroke显示文摘 | Margaritescu O Pirici D Margaritescu C | 2011 | Rom J Mor phol Embryol2011，52，4： | 1 |
| 6 | Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls显示文摘 | Kumar-Singh S Pirici D McGowan E Serneels S Ceuterick C Hardy J | 2005 | Am J Pathol2005，167，2： | 1 |
| 7 | VEGF expression in human brain tissue after acute ischemic stroke显示文摘 | M(a)rg(a)ritescu O Pirici D M(a)rg(a)ritescu C | | 0，，： | 1 |
| 8 | B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma显示文摘AIM To study the morphology of the enteric nervous system and the expression of beta-2 adrenergic(B2A) receptors in primary colorectal cancer.METHODS In this study, we included forty-eight patients with primary colorectal cancer and nine patients for control tissue from the excision of a colonic segment for benign conditions. We determined the clinicopathological features and evaluated the immunohistochemical expression pattern of B2 A receptors as well as the morphological changes of the enteric nervous system(ENS). In order to assess statistical differences, we used the student t-test for comparing the means of two groups and one-way analysis of variance with Bonferroni's post hoc analysis for comparing the means of more than two groups. Correlations were assessed using the Pearson's correlation coefficient.RESULTS B2 A receptors were significantly associated with tumor grading, tumor size, tumor invasion, lymph node metastasis(P < 0.05), while there were no statistically significant associations with gender, CRC location and gross appearance(P > 0.05). We observed, on one hand, a decrease of the relative area for both Auerbach and Meissner plexuses with the increase of the tumor grading, and on the other hand, an increase of the relative area of other nervous elements not in the Meissner plexus or in the Auerbach plexus with the tumor grading. For G1 tumors we found that epithelial B2 A area showed an inverse correlation with the Auerbach plexus areas [r(14) =-0.531, P < 0.05], while for G2 tumors, epithelial B2 A areas showed an indirect variation with both the Auerbach plexus areas [r(14) =-0.453, P < 0.05] and the Meissner areas [r(14) =-0.825, P < 0.01]. For G3 tumors, the inverse dependence increased for both Auerbach [r(14) =-0.587, P < 0.05] and Meissner [r(14) =-0.934, P < 0.05] plexuses.CONCLUSION B2 A receptors play an important role in colorectal carcinogenesis and can be utilized as prognostic factors. Furthermore, study of the ENS in colorectal cancer may lead to targeted molecular therapies. | Raluca Niculina Ciurea Ion Rogoveanu Daniel Pirici Georgica-Costinel Tartea Costin Teodor Streba Cristina Florescu Bogdan Catalin Ileana Puiu Elena-Anca Tartea Cristin Constantin Vere | 2017 | World Journal of Gastroenterology2017，23，7： | 1 |
| 9 | Stem cells, colorectal cancer and cancer stem cell markers correlations 显示文摘 | Cherciu I Barbalan A Pirici D | 2014 | Curt Health Sci J2014，40，3： | 1 |
| 10 | The u-tility of CD44,CD117 and CD133 in identification of cancerstem cells(CSC)in oral squamous cell carcinomas(OSCC)显示文摘 | MRGRITESCU C PIRICI D SIMIONESCU C | 2011 | Rom J Morphol Embryol2011，52，： | 1 |
| 11 | VEGF expression in human brain tissue after acute ischemic stroke 显示文摘 | Otilia Margaritescu Pirici D Margaritescu C L | 2011 | Rom J Morphol Embryol2011，52，4： | 1 |
| 12 | Mucinous adenocarcinoma of the colon-a histochemical study显示文摘 | IonilàM Màrgàritescu C Pirici D | 2011 | Rom J Morphol Embryol2011，52，3： | 1 |
| 13 | VEGF expression in human brain tissue after acute ischemic stroke 显示文摘 | Margaritescu O Pirici D Margaritescu C | 2011 | Rom J Morphol Embryol2011，52，4： | 1 |
| 14 | Tumor angiogenesis, macrophages and mast cell microdensities in endometrioidendometrial carcinoma显示文摘 | Cristiana Simionescu Claudiu M?rg?ritescu Alex Stepan Daniel Pirici Raluca Ciurea Nicolae Cernea | 2013 | Oncology Letters2013，，2： | 1 |
| 15 | Different dynamics of aquaporin4 and glutamat etransporter-ldistribution in the perineuronal and perivascular compartments during ischenfic stroke显示文摘 | Mogoanta L Ciurea M Pirici I | 2014 | Brain Pathol2014，24，5： | 1 |
| 16 | VEGF and VEGFRs expression in oral squamous cell carcinoma显示文摘 | Mrgritescu C Pirici D Simionescu C | 2009 | Rom J Morphol Embryol2009，50，4： | 1 |
| 17 | CD133/CD166/Ki-67 tri- ple immunofluoreseence assessment for putative cancer stem ceils in colon carcinoma显示文摘 | Mrgaritescu C Pirici D Chereiu I | 2014 | J Gastrointestin Liver Dis2014，23，2： | 1 |
| 18 | VEGF expression in human brain tissue after acute ischemic stroke显示文摘 | Margaritescu O Pirici D Margaritescu C | 2011 | Rom J Morphol Embryol2011，52，： | 1 |
| 19 | VEGF ex- pression in human brain tissue after acute ischemic stroke显示文摘 | Mgaritescu O Pirici D Mrgaritescu C | 2011 | Rom J Morphol Embryol2011，52，4： | 1 |
| 20 | VEGF expression in human brain tissue after acute ischemic stroke 显示文摘 | Margaritescu O Pirici D Margaritescu C | 2011 | Rom J Morphol Embryol2011，52，4： | 1 |
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