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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Liquid products from the cotinuous flash pyrolysis of biomass 显示文摘 | Scott D S Piskorz J Radlein D | 1985 | Ind Eng Chen Process Des Dev1985，24，3： | 1 |
| 3 | Isolated retroperitoneal mixed germ cell tumor presenting as acute abdomen: case report 显示文摘 | Misiak P Piskorz L Jablofiski S | 2013 | Conternp Oncol (Pozn)2013，17，1： | 1 |
| 4 | On the mechanism of rapid pyrolysis of cellulose显示文摘 | Piskorz J Radlein D S Scott D S | 1986 | Journal of Analytical and Applied Pyrolysis1986，9，1： | 1 |
| 5 | A second look at fast pyrolysis of biomassthe RTI process显示文摘 | DONALD S SCOTT PIOTR MAJERSKI JAN PISKORZ | 1999 | Journal of Analytical and Applied Pyrolysis1999，51，： | 1 |
| 6 | Situational determinants of envy and schadenfreude显示文摘 | Joanna E Piskorz Zbigniew Piskorz | | 0，，03： | 1 |
| 7 | Liquid products from the comtinuo us flash pyrolysis lf biomass显示文摘 | Scott D S Piskorz J Radlein D | 1985 | Industrial&Engineering Chemistry Process Design and Development1985，，3： | 1 |
| 8 | On the Mechanism of the Rapid Pyrolysis of Cellulose显示文摘 | PISKORZ J RADLEIN D SCOTT D S | 1986 | Journal of Analytical and Applied pyrolysis1986，，9： | 1 |
| 9 | A second look at fast pyrolysis of biomass the RTI process显示文摘 | SCOTTA D S MAJERSKI P PISKORZ J RADLEIN D | | 0，，1： | 1 |
| 10 | A second look at fast pyrolys is of biomass-the RTI process显示文摘 | Scott D S Majerski P Piskorz J | 1999 | Journal of Analytic al and Applied Pyrolysis1999，，12： | 1 |
| 11 | Conversion of liginins to hydrocabon Fuels 显示文摘 | PISKORZ J MAJERSKI P RADILEIN D | 1989 | Energy & Fuels1989，，3： | 1 |
| 12 | Catalytic pyrogasification of biomass,evaluation of modified Nickel catalysts显示文摘 | ARAUZO J RADLEIN D PISKORZ J | 1997 | Industrial and Engineering Chemistry Research1997，36，1： | 1 |
| 13 | A new catalyst for the catalytic gasification of biomass 显示文摘 | ARAUZO J RADLE IN D PISKORZ J SCOTT D S | 1994 | Energy Fuels1994，8，6： | 1 |
| 14 | Biochemical and functional indices of malnutrition in patients with operable, non-mierocelullar lung cancer显示文摘 | PISKORZ L LESIAK T BROCKI M | 2011 | Nutr Hosp2011，26，5： | 1 |
| 15 | Liquid products from the cotinuous flash pyrolysis of biomass 显示文摘 | Scott D S Piskorz J Radlein D | 1985 | Indastrial and Engineering Chemistry Process Design and Development1985，24，3： | 1 |
| 16 | Pretreatment processes to increase pyrolytic yield of levoglucosan from herbaceous feedstocks显示文摘 | Radlein D Piskorz J | 2001 | ACS Symposium Series2001，784，： | 1 |
| 17 | On the mechanism of rapid pyrolysis of cellulose显示文摘 | Radlein D S Scott D S | 1986 | Journal of Analytical and Applied Pyrolysis1986，9，1： | 1 |
| 18 | Assessment of adhesion formation after laparoscopic intraperitoneal implantation of Dynamesh IPOM mesh 显示文摘 | Jamry A1 Jalyfiski M M Piskorz L | 2013 | Arch Med Sci2013，9，3： | 1 |
| 19 | The role of temperature in the fast pyrolysis of cellulose and wood显示文摘 | PISKORZ J BERGOUGNOU M A | 1988 | Ind Eng Chem Res1988，27，1： | 1 |
| 20 | Biochemical and functional indices of malnutrition in patients with operable, non-microcelullar lung cancer显示文摘 | PISKORZ L LESIAK T BROCKI M | 2011 | Nutr Hosp2011，26，5： | 1 |
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