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| 1 | Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic,uncomplicated colonic diverticular disease显示文摘AIM: To comparatively evaluate the long term efficacy of Rifaximin and dietary fibers in reducing symptoms and/or complication frequency in symptomatic, uncomplicated diverticular disease. METHODS: 307 patients (118 males, 189 females, age range: 40-80 years) were enrolled in the study and randomly assigned to: Rifaximin (400 mg bid for 7 d every month) plus dietary fiber supplementation (at least 20 gr/d) or dietary fiber supplementation alone. The study duration was 24 mo; both clinical examination and symptoms’ questionnaire were performed every two months. RESULTS: Both treatments reduced symptom frequency, but Rifaximin at a greater extent, when compared to basal values. Symptomatic score declined during both treatments, but a greater reduction was evident in the Rifaximin group (6.4 ± 2.8 and 6.2 ± 2.6 at enrollment, P = NS, 1.0 ± 0.7 and 2.4 ± 1.7 after 24 mo, P < 0.001, respectively). Probability of symptom reduction was higher and complication frequency lower (Kaplan-Meyer method) in the Rifaximin group (P < 0.0001 and 0.028, respectively). CONCLUSION: In patients with symptomatic, uncomplicated diverticular disease, cyclic administration of Rifaximin plus dietary fiber supplementation is more effective in reducing both symptom and complication frequency than simple dietary fiber supplementation. Long term administration of the poorly absorbed antibiotic Rifaximin is safe and well tolerated by the patients,confirming the usefulness of this therapeutic strategy in the overall management of diverticular disease. | Antonio Colecchia Amanda Vestito Francesca Pasqui Giuseppe Mazzella Enrico Roda Francesca Pistoia Giovanni Brandimarte Davide Festi | 2007 | World Journal of Gastroenterology2007，13，2： | 21 |
| 2 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 3 | Immunoregulatory func- tion of mesenchymal stem cells 显示文摘 | UCCELLI A MORETTA L PISTOIA V | 2006 | Eur J Immunol2006，36，10： | 1 |
| 4 | Small particle-size lithium-vanadium oxide: an improved cathode material for high rate rechargeable lithium batteries 显示文摘 | Pistoia G Pasquali M Geronov Y | 1989 | J Power Sources1989，27，1： | 1 |
| 5 | Mesenchymal stem cells in health and disease显示文摘 | Uccelli A Moretta L Pistoia V | 2008 | Nat Rev Immunol2008，8，9： | 1 |
| 6 | Li/Li1+xV3O8 secondary batteries显示文摘 | Pistoia G Pasquali M Wang G | 1990 | J Electrochem Soc1990，137，8： | 1 |
| 7 | Li+ insertion into Mn spinel phases显示文摘 | Pistoia G Wang G Wang C | 1992 | SolidState Ionics1992，，58： | 1 |
| 8 | Behavioral therapy for chronic migraine显示文摘 | Pistoia F Sacco S Carolei A | 2013 | Curt Pain Headache Rep2013，17，1： | 1 |
| 9 | Lymphoproliferative disorders and chemokines显示文摘 | Pistoia V Corcione A Dallegri F | 2006 | Curr Drug Targets2006，7，1： | 1 |
| 10 | Sex after stroke, A CNS only dys- function? 显示文摘 | Pistoia F Govoni S Boselli C | 2006 | Pharmacol Res2006，54，1： | 1 |
| 11 | Mesenchymal stem cells in health anddisease 显示文摘 | Uccelli A Moretta L Pistoia V | 2008 | Nat Rev Immunol2008，8，： | 1 |
| 12 | Mesenchymal stem cells: a new strategy for immunosuppression 显示文摘 | Uccelli A Pistoia V Moretta L | 2007 | Trends Immunol2007，28，5： | 1 |
| 13 | Li/Li+V3OaSecandary Batteries Synthesis and Characterization of an Amorphous Form of the Cathode显示文摘 | Pistoia G Pasquali M Wang G | 1990 | Journal of The Electrochemical Society1990，137，8： | 1 |
| 14 | Splenic lymphangiomatosis: CT diagnosis显示文摘 | Pistoia F Markowitz SK | 1988 | AJR1988，150，1： | 1 |
| 15 | Mesenchymal stem ceils in health and disease显示文摘 | Uccelli A Moretta L Pistoia V | | 0，，09： | 1 |
| 16 | Immunoregulatory function of mesenchymal stem cells显示文摘 | Uccelli A Moretta L Pistoia V | | 0，，10： | 1 |
| 17 | Mixed Na/K vanadates for rechargeable Li batteries显示文摘 | Pistoia G Wang G Zane D | 1995 | Solid State Ionics1995，76，34： | 1 |
| 18 | Storage characteristices of cathodes for Li-ion batteries 显示文摘 | PISTOIA G ANTONINI A ROSOTI R | 1996 | Electrochem Acta1996，17，4： | 1 |
| 19 | Locating the peaks of the least energy solutions to an ellyptic system with Neumann boundary conditions显示文摘 | Angela Pistoia Miguel Ramos | 2004 | Journal of Differential Equations2004，，1： | 1 |
| 20 | High-affinityZn2+ uptakesystemZnuABCisrequiredforbacterialzinchomeostasisinintracellularenvironmentsandcontributestothevirulenceofSalmonellaenteric显示文摘 | AMMENDOLAS PASQUALIP PISTOIA C etal | 2007 | InfectImmun2007，75，12： | 1 |
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