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| 1 | Pathophysiology of pulmonary complications of acute pancreatitis显示文摘Acute pancreatitis in its severe form is complicated by multiple organ system dysfunction, most importantly by pulmonary complications which include hypoxia, acute respiratory distress syndrome, atelectasis, and pleural effusion. The pathogenesis of some of the above complications is attributed to the production of noxious cytokines. Clinically significant is the early onset of pleural effusion, which heralds a poor outcome of acute pancreatitis. The role of circulating trypsin, phospholipase A2, platelet activating factor, release of free fatty acids, chemoattractants such as tumor necrsosis factor (TNF)- alpha, interleukin (IL)-1, IL-6, IL-8, fMet-leu-phe (a bacterial wall product), nitric oxide, substance P, and macrophage inhibitor factor is currently studied. The hope is that future management of acute pancreatitis with a better understanding of the pathogenesis of lung injury will be directed against the production of noxious cytokines. | George W Browne CS Pitchumoni | 2006 | World Journal of Gastroenterology2006，12，44： | 57 |
| 2 | Acute pancreatitis in pregnancy显示文摘Acute pancreatitis (AP) is a rare event in pregnancy, occurring in approximately 3 in 10 000 pregnancies. The spectrum of AP in pregnancy ranges from mild pancreatitis to serious pancreatitis associated with necrosis, abscesses, pseudocysts and multiple organ dysfunction syndromes. Pregnancy related hematological and biochemical alterations infl uence the interpretation of diagnostic tests and assessment of severity of AP. As in any other disease associated with pregnancy, AP is associated with greater concerns as it deals with two lives rather than just one as in the non-pregnant population. The recent advances in clinical gastroenterology have improved the early diagnosis and effective management of biliary pancreatitis. Diagnostic studies such as endoscopic ultrasound, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography and therapeutic modalities that include endoscopic sphincterotomy, biliary stenting, common bile duct stone extraction and laparoscopic cholecystectomy are major milestones in gastroenterology. When properly managed AP in pregnancy does not carry a dismal prognosis as in the past. | Capecomorin S Pitchumoni Balaji Yegneswaran | 2009 | World Journal of Gastroenterology2009，15，45： | 57 |
| 3 | Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy显示文摘AIM:To analyze the prevalence of gastroesophageal reflux disease (GERD) related symptoms in patients with diabetes mellitus (DM) and to find out the relationship between diabetic neuropathy and the prevalence of GERD symptoms. METHODS:In this prospective questionnaire study, 150 consecutive type 2 diabetic patients attending the endocrine clinic were enrolled. A junior physician helped the patients to understand the questions. Patients were asked about the presence of five most frequent symptoms of GERD that included heartburn (at least 1/wk), regurgitation, chest pain, hoarseness of voice and chronic cough. Patients with past medical history of angina, COPD, asthma, cough due to ACEI or preexisting GERD prior to onset of diabetes and apparent psychiatric disorders were excluded from the survey. We further divided the patients into two groups based on presence or absence of peripheral neuropathy. Out of 150 patients, 46 had neuropathy, whereas 104 patients did not have neuropathy. Data are expressed as mean ± SD, and number of patients in each category and percentage of total patients in that group. Normal distributions between groups were compared with Student t test and the prevalence rates between groups were compared with Chi-square tests for significance. RESULTS:The average duration of diabetes were 12 ± 9.2 years and the average HbA1c level of this group was 7.7% ± 2.0%. The mean weight and BMI were 198 ± 54 lbs. and 32 ± 7.2 kg/m2. Forty percent (61/150) patients reported having at least one of the symptoms of GERD and thirty percent (45/150) reported having heartburn at least once a week. The prevalence of GERD symptoms is higher in patients with neuropathy than patients without neuropathy (58.7% vs 32.7%, P < 0.01). The prevalence of heartburn, chest pain and chronic cough are also higher in patients with neuropathy than in patients without neuropathy (43.5% vs 24%;10.9% vs 4.8% and 17.8% vs 6.7% respectively, P < 0.05).CONCLUSION:The prevalence of GERD symptoms in type 2 DM is higher than in the general population. Our data suggest that DM neuropathy may be an important associated factor for developing GERD symptoms. | Xiangbing Wang CS Pitchumoni Khushbu Chandrarana Neha Shah | 2008 | World Journal of Gastroenterology2008，14，5： | 13 |
| 4 | Pravastatin:A potential cause for acute pancreatitis显示文摘Acute pancreatitis (AP) secondary to drugs is un- common, with an incidence ranging from 0.3% to 2.0% of AP cases. Drug-induced AP due to statins is rare, and only 12 cases have thus far been reported. In this case report, we report a case of a 50-year-old female on pravastatin therapy for 3 d prior to developing symptoms of AP. The common etiological factors for AP were all excluded. The patient was admitted to the intensive care unit secondary to respiratory distress, though she subsequently improved and was discharged 14 d after admission. Although the incidence of drug-induced AP is low, clinicians should have a high index of suspicion for it in patients with AP due to an unknown etiology. Clinicians should be aware of the association of statins with AP. If a patient taking a statin develops abdominal pain, clinicians should consider the diagnosis of AP and conduct the appropriate laboratory and diagnostic evaluation if indicated. | Constantine Tsigrelis CS Pitchumoni | 2006 | World Journal of Gastroenterology2006，12，43： | 5 |
| 5 | Pathogenesis and managenent of pain in chronic pancreatitis显示文摘INTRODUCTIONOf the three cardinal manifestations of chronic pancreatitis-pain,diabetes mellitus and steatorrhea,it is pain thatbrings the patient to the physician and is the most difficultto manage.The intractabale pain that is quite | C. S. Pitchumoni | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 6 | Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C显示文摘 | Dhiraj Yadav Hilary I Hertan P Schweitzer E.P Norkus C.S Pitchumoni | 2002 | The American Journal of Gastroenterology2002，，10： | 2 |
| 7 | Issues in Hyperlipidemic Pancreatitis显示文摘 | Dhiraj Yadav C. S. Pitchumoni | 2003 | Journal of Clinical Gastroenterology2003，，1： | 2 |
| 8 | Diabetic Ketoacidosis,hyperlipidemia,and acute pancreatitis:the enigmatic triangle显示文摘 | Nair S Pitchumoni CS | 1997 | Am J Gastroenterol1997，92，9： | 1 |
| 9 | Pancreatic pseudocysts:when and how should drainage be performed显示文摘 | Pitchumoni CS Agarwal N | 1999 | Gastroenterol Clin1999，28，： | 1 |
| 10 | Issues in hyperlipidemic pancreatitis显示文摘 | YADAV D PITCHUMONI C S | 2003 | J Clin Gastroenterol2003，36，： | 1 |
| 11 | Issues in hyperlipidemic pancreatitis显示文摘 | Yadav D Pitchumoni CS | | 0，，01： | 1 |
| 12 | Fluid collections in and around the pancreas in acute pancreatitis 显示文摘 | Brun A1 Agarwal N Pitchumoni CS | 2011 | J Clin Gastroenterol2011，45，7： | 1 |
| 13 | Issues in hyperlipidemic pancreatitis显示文摘 | Yadav D Pitchumoni CS | 2003 | J Gastroenterol2003，36，1： | 1 |
| 14 | Ulcerative colitis and autoimmune pancreatitis显示文摘 | Pitchumoni CS Chari S | 2013 | J Clin Gastroenterol2013，47，6： | 1 |
| 15 | Issues in hy-perlipidelmic panereatitis显示文摘 | Yadav D Pitchumoni CS | 2003 | J Clin Gastroenterol2003，36，1： | 1 |
| 16 | Association of diabetic ketoacidosis and acute pancreatitis:observations in 100consecutive episodes ofDKA显示文摘 | Nair S Yadav D Pitchumoni CS | | 0，，10： | 1 |
| 17 | Issues in hyperlipidemic Pancreatitis显示文摘 | Yadav P Pitchumoni CS | 2003 | J Clin Gastroenterol2003，36，1： | 1 |
| 18 | Issues in hyperlipidemic pancreatitis显示文摘 | Yadav D Pitchumoni CS | 2003 | J Clin Gastroenterol2003，36，1： | 1 |
| 19 | Association of diabetic ketoacidosis and acute pancreatitis:observations in 100 consecutive episodes of DKA显示文摘 | Nair S1 Yadav D Pitchumoni CS | 2000 | Am J Gastmenterol2000，95，10： | 1 |
| 20 | Pancreatitis ininflammatory bowel disease 显示文摘 | Pitchumoni CS Rubin A Das K | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
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