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| 1 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 2 | Prednisolone disposition in obese men显示文摘 | Milsap RL Plaisance KI Jusko WJ | 1984 | Clin Pharmacol Ther1984，36，6： | 1 |
| 3 | |3l-Integrin is up-regulated via Raci-dependent reactive oxygen species as part of the hypertrophiccardiomyocyte response显示文摘 | Hauselmann S P Rosc-Schliiter B I Lorenz V Plaisance I Brink M Pfister 0 | 2011 | Free Radic Biol Med2011，51，： | 1 |
| 4 | Toxicities of drugs used in the management of fever显示文摘 | Plaisance KI | 2000 | Clin Infect Dis2000，31，5： | 1 |
| 5 | Pharmacokinetic and thrombolytic properties of cysteine-linked polyethylene glycol derivatives of staphylokinase显示文摘 | Vanwetswinkel S Plaisance S Zhang Zhi-Yong | 2000 | Blood2000，95，3： | 1 |
| 6 | Description and redescription of Haliotrema species (Monogenoidea: Poloyonchoinea :Dactylogyridae) parasitizing butterfly fishes ( Teleostei : Chaetodontidae) in the Indo-West Pacific Ocean 显示文摘 | Laetitia Plaisance Salah Bouamer Serge Morand | 2004 | Parasitol Res2004，93，： | 1 |
| 7 | Toxicities of drugs used in the management of fever显示文摘 | PLAISANCE K L | 2000 | Clinical Infectious Diseases2000，31，5： | 1 |
| 8 | Nursing Students' Knowledge and Attitudes Regarding Pain显示文摘 | Plaisance L Logan C | 2006 | Pain Manag Nurs2006，7，4： | 1 |
| 9 | p38 and extracellular signal- regulated kinase mitogen- activated protein kinase pathways are required for nuclear factor- kappa B p65transactivation mediated by tumor necrosis factor显示文摘 | Vanden Berghe W Plaisance S Boone E | 1998 | J Biol Chem1998，273，6： | 1 |
| 10 | Nursing students’ knowledge and attitudesregarding pain显示文摘 | Plaisance L Logan C | 2006 | Pain Manag Nurs2006，7，4： | 1 |
| 11 | The influence of sex,body composition,and nonesterified fatty acids on serum adipokine concentrations显示文摘 | Plaisance EP Grandiean PW Judd RL | | 0，，11： | 1 |
| 12 | Field investigation on the removal of formaldehyde in indoor air显示文摘 | Plaisance H Blondel A Desauziers V | 2013 | Building & Environment2013，70，6： | 1 |
| 13 | Pharmacokinetic and thrombolytic properties of cysteine - linked polyethylene glycol derivatives of staphylokinase显示文摘 | Vanwetswinkel S Plaisance S Zhi - Yong Z | 2000 | Blood2000，95，： | 1 |
| 14 | Pharmacokinetic and thrombolytic properties of cysteine-linked polyethylene glycol derivatives of staphylokinase 显示文摘 | Vanwetswinkel S Plaisance S Zhang Z | 2000 | Blood2000，95，3： | 1 |
| 15 | TNF-α increases protein content in C2C12 and primary myotubes by enhancing protein translation via the TNF-R1,PI3-kinase and MEK显示文摘 | Plaisance I Morandi C Murigande C | | 0，，： | 1 |
| 16 | MicroRNA-9 controls the expression of granuphilin/ s1p4 and the secretory response of insulin-producing cells显示文摘 | Plaisance V Abderrahmani A Perret-Menoud V | 2006 | J Biol Chem2006，281，26： | 1 |
| 17 | The complete mitochondrial DNA sequence of the monogenean Gyrodactylus thymalli (Platyhelminthes:Monogenea),a parasite of grayling (Thymallus thymallus)显示文摘 | Plaisance L Huyse T Littlewood D T | | 0，，02： | 1 |
| 18 | MicroRNA- 9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells 显示文摘 | Plaisance V Abderrahmani A Perret-Menoud V | 2006 | J Biol Chem2006，281，26： | 1 |
| 19 | The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis显示文摘 | Van de Wouwer M Plaisance S De Vriese A | 2006 | Thromb Haemost2006，4，8： | 1 |
| 20 | MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells显示文摘 | Plaisance V Abderrahmani A Perret-Menoud V | | 0，，： | 1 |
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