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| 1 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Transient monocular blindness : The controversial role of the ophthalmic artery 显示文摘 | Petzold A Islam N Plant GT | 2004 | J Neurol2004，251，7： | 1 |
| 3 | G Protein-cou- pled estrogen receptor (GPER) expression in normal and ab- normal endometrium显示文摘 | Plante B J Lessey B A Taylor R N | 2012 | Reprod Sci2012，19，7： | 1 |
| 4 | How best to teach CPR to schoolchildren A systematic review显示文摘 | Plant N Taylor K | 2013 | Resuscitation2013，84，4： | 1 |
| 5 | Aftermath of surgery for anorectal cancer显示文摘 | Devlin HB Plant JA Griffin N | 1971 | Br Med J1971，3，5： | 1 |
| 6 | Transient monocular blindness:the controversial role of the ophthalmic artery显示文摘 | Petzold A Islam N Plant GT | 2004 | J Neurol2004，251，7： | 1 |
| 7 | Temporal differentiation of optical signals using a phase-shifted fiber Bragg grating显示文摘 | Berger N K Levit B Fischer B Kulishov M Plant D V Aza(n)a J | | 0，，02： | 1 |
| 8 | Antigenic and molecular conservation of the gonococcal NspA protein显示文摘 | Plante M Cadieux N Rioux CR | | Infect0，，： | 1 |
| 9 | Antigenic and molecular conservation of the gonococcal NspA protein显示文摘 | Plante M Cadieux N Rioux CR | 1999 | Infect Immun1999，67，6： | 1 |
| 10 | G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and bnormal Endometrium 显示文摘 | Plante B J Lessey B A Taylor R N | 2012 | Reprod Sci2012，19，7： | 1 |
| 11 | Amyloid beta peptide as a physiological modulator of neuronal ' A' -type K+ e urrent显示文摘 | Plant LD Webster N J Boyle JP | 2006 | Neurobiol Aging2006，27，11： | 1 |
| 12 | G protein-cou- pled estrogen receptor (GPER) expression in normal and ab- normal endometrium显示文摘 | Plante B J Lessey B A Taylor R N | 2012 | Reprod Sci2012，19，7： | 1 |
| 13 | Transient monocular blindness: The controversial role of the ophthalmic artery 显示文摘 | Petzold A Islam N Plant GT | 2004 | J Neurol2004，251，7： | 1 |
| 14 | The application of Beckman Coulter VCS technology at a major cancer cen- ter, with emphasis on the detection of circulating immature plasma cells in plasma cell leukemia 显示文摘 | Marionneaux S Monsalve B Plante N | 2006 | Lab Hematol2006，12，4： | 1 |
| 15 | Sodium valproate induces apoptosis in the rat hepatoma cell line, FaO显示文摘 | Phillips A Bullock T Plant N | 2003 | Toxicology2003，192，23： | 1 |
| 16 | Cadmium levels in Europe:Implications for human health显示文摘 | Pan J Plant J A Voulvoulis N | 2010 | Environ Geochem Health2010，32，1： | 1 |
| 17 | A common cardiac sodium channel variant associated with sudden infant death in african americans,scn5a s1103y显示文摘 | PLANT L D BOWERS P N LIU Q | 2006 | J Clin Invest2006，116，： | 1 |
| 18 | Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome 显示文摘 | Shenoy M Plant N D Lewis M A | 2010 | Pediatr Nephrol2010，25，5： | 1 |
| 19 | How best to teach CPR to schoolchildren :a systematic review显示文摘 | Plant N Taylor K | 2013 | Resuscitation2013，84，4： | 1 |
| 20 | Palladium gold removal recovery from precious metal solutions electronic scrap leachates by desulfovibrie Desulfuricans显示文摘 | Creamer N J Baxter Plant Victoria S Henderson John | 2006 | Biotechnology Letters2006，28，18： | 1 |
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