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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 3 | Phase separation in epoxy resin-reactive dendritic hyperbranched polymer blends显示文摘 | PLUMMER C J G MEZZENGA R BOOGH L | 2001 | Polymer Engineering and Science2001，41，： | 1 |
| 4 | Seizure detection:correlation of human experts 显示文摘 | WILSON K SCHEUER M L PLUMMER C | 2003 | Clinl Neurophysi- ol2003，114，11： | 1 |
| 5 | Morphology build-up in dendritic hyperbranehed polymer modified epoxy resins : modelling and characterization 显示文摘 | MEZZENGA R PLUMMER C J G BOOGH L | 2001 | Polymer2001，42，： | 1 |
| 6 | Assessing benefit transfer for the valuation of ecosystem services显示文摘 | Plummer M L | 2009 | Frontiers in Ecology and the Environment2009，7，1： | 1 |
| 7 | The use of simulation and multiple environmental tracers to quantify groundwater flow in a shallow aquifer显示文摘 | Reilly T E Plummer L N Phillips P J | 1994 | Water Resources Research1994，30，： | 1 |
| 8 | Antimicrobial properties of AUium sativura (garlic)显示文摘 | HARRIS J C COTTRELL S L PLUMMER S | 2001 | Appl Microbiol Biotechnol2001，57，3： | 1 |
| 9 | A phase Ⅰ dose escalation study of AT9283,a small molecule inhibitor of aurora kinases in patients with advanced solid malignancies显示文摘 | ARKENAU H T PLUMMER R MOLIFE L R | 2012 | Ann Oncol2012，23，5： | 1 |
| 10 | Antimicrobial properties of Allium sativum ( garlic ) 显示文摘 | Harris J C Cottrell S L Plummer S | 2001 | Appl Microbiol Biotechnol2001，57，： | 1 |
| 11 | The influence of crown rust on tiller production and survival of peren- nial ryegrass (Lolium perenne ) plants in simulated swards显示文摘 | Plummer R M Hall R L Watt T A | 1990 | Grass and Forge Science1990，45，： | 1 |
| 12 | IL-7- Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation 显示文摘 | Koesters SA Alimonti JB Wachihi C Matu L Anzala O Kimani J Embree JE Plummer FA Fowke KR | 2006 | Eur J Immunol2006，36，2： | 1 |
| 13 | What is an entrepreneurial opportunity显示文摘 | MCMULLEN J S PLUMMER L A ACS Z J | 2007 | Small Business Economics2007，28，4： | 1 |
| 14 | The long-term clinical tbllow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism显示文摘 | Dwyer AA Hayes F J Plummer L | 2010 | The Journal of clinical endocrinology and metabolism2010，95，9： | 1 |
| 15 | Impact of invasive water hyacinth (Eichhornia crassipes)on snail hosts of Schistosomiasis in Lake Victoria, east Africa 显示文摘 | Plummer M L | 2005 | Econology Health2005，2，： | 1 |
| 16 | Geochemical modeling of the Madison aquifer inparis of Montana and South Dokota 显示文摘 | Plummer L N Busby J F Lee R W | 1990 | Water Resource Research1990，26，9： | 1 |
| 17 | Fire assay for platinum and palladium in ores and concentrates显示文摘 | Plummer M E V Lewis C L Beamish F E | 1959 | Analytical Chemistry1959，31，2： | 1 |
| 18 | Hypnotic and anaesthetic interactions between midazolam, propofol and alfentanil显示文摘 | SHORT T G PLUMMER J L CHUI P T | 1992 | Br J Anaesth1992，69，2： | 1 |
| 19 | 显示文摘 | Mezzenga R Plummer C J G Boogh L | 2001 | Polymer2001，42，： | 1 |
| 20 | Development of reaction models for groundwater systems显示文摘 | Plummer L N Parkhurst D L Thorstenson D C | 1983 | Ceochimica et Cosmochimica Acta1983，47，： | 1 |
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