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| 1 | 全流量大鼠体外循环模型的建立显示文摘目的建立可存活全流量的大鼠体外循环(cardiopulmonary bypass,CPB)模型。方法8只雄性Sprague-Dawley大鼠异氟烷吸入诱导麻醉后,经口气管内插管,接呼吸机行机械通气。进行尾动脉、腹壁尾侧浅动静脉和右侧颈外静脉血管穿刺置管等外科准备。经颈外静脉置入的多孔套管为静脉引流通道,以经尾动脉置入套管为CPB动脉灌注管道,血液经过特制膜氧合器进行氧合建立CPB并进行90 min CPB灌注。实验动物均进行血气和血流动力学等基本生理指标监测,并在CPB前、CPB后60 min以及CPB后1周测定细胞因子(IL-6和IL-10)以了解CPB所致的大鼠全身炎症情况。结果成功建立了不输血全流量大鼠CPB模型,所有实验动物全部存活至7天以上。受试动物IL-6和IL-10在CPB后显著升高,一周后回降到术前正常水平。结论本实验成功建立了全流量大鼠CPB模型,CPB后大鼠出现明显的全身炎症反应,这为研究CPB并发症病理生理机制以及相应的应对策略提供可靠经济的动物模型。 | 朱斌 Mihai V. Podgoreanu G. Burkhard Mackensen 叶铁虎 黄宇光 | 2009 | 中国体外循环杂志2009，7，3： | 7 |
| 2 | Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery 显示文摘 | Mathew JP Podgoreanu MV Groeott HP | 2007 | J Am Coll Cardiol2007，49，19： | 1 |
| 3 | Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team:Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery显示文摘 | Stafford-Smith M Podgoreanu M Swaminathan M | 2005 | Am J Kidney Dis2005，3，45： | 1 |
| 4 | A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper 显示文摘 | Lange FD Yoshitani K Podgoreanu M | 2008 | J Cardiothorac Surg2008，3，8： | 1 |
| 5 | Inflamma-tory gene polymorphisms and risk of postoperative myocar-dial infarction after cardiac surgery 显示文摘 | Podgoreanu MV White WD Morris RW | 2006 | Circulation2006，114，1： | 1 |
| 6 | Genetic vari-ants in P-selectin and C-reactive protein influence suscepti-bility to cognitive decline after cardiac surgery显示文摘 | Mathew JP Podgoreanu MV Grocott HP | | 0，，19： | 1 |
| 7 | A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper显示文摘 | de Lange F Yoshitani K Podgoreanu MV | 2008 | J Cardiothorae Surg2008，，3： | 1 |
| 8 | Cognitive Function after Major Noncardiac Surgery, Apolipoprotein E4 Genotype, and Biomarkers of Brain Injury显示文摘 | David L. McDonagh Joseph P. Mathew Willam D. White Barbara Phillips-Bute Daniel T. Laskowitz Mihai V. Podgoreanu Mark F. Newman | 2010 | Anesthesiology2010，，4： | 1 |
| 9 | A novel surviv- al model of cardioplegic arrest and cardiopulmonary bypass in rats : a methodology paper显示文摘 | de Lange F Yoshitani K Podgoreanu M V | 2008 | J Cardiothorac Surg2008，3，： | 1 |
| 10 | A novel sur vival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper 显示文摘 | De Lange F Yoshitani K Podgoreanu MV | 2008 | J Cardiothorac Surg2008，3，： | 1 |
| 11 | Differential cardiac gene expression during cardiopulmonary bypass: ischemiaindependent upregulation of preinflammatory genes显示文摘 | Podgoreanu MV Michdotti GA Sato Y | 2005 | J Thorac Cardiovasc Surg2005，130，2： | 1 |
| 12 | Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery显示文摘 | Mathew JP Podgoreanu MV Grocott HP | 2007 | Am Coll Cardiol2007，49，19： | 1 |
| 13 | A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper 显示文摘 | de Lange F Yoshitani K Podgoreanu MV | 2008 | J Cardiothorac Surg2008，3，： | 1 |
| 14 | Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team: Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery 显示文摘 | Stafford-Smith M Podgoreanu M Swaminathan M | 2005 | Am J Kidney Dis2005，45，： | 1 |
| 15 | Pulse Pressure and Long-Term Survival After Coronary Artery Bypass Graft Surgery显示文摘 | Nikolay M. Nikolov Manuel L. Fontes William D. White Solomon Aronson Shahar Bar-Yosef Jeffrey G. Gaca Mihai V. Podgoreanu Mark Stafford-Smith Mark F. Newman Joseph P. Mathew | 2010 | Anesthesia & Analgesia2010，，： | 1 |
| 16 | Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery显示文摘 | Mathew J P Podgoreanu M V Grocott H P | 2007 | J Am Coll Cardiol2007，49，19： | 1 |
| 17 | A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats : a methodology paper 显示文摘 | De Lange F Yoshitani K Podgoreanu MV | 2008 | J Cardiothorac Surg2008，3，： | 1 |
| 18 | Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery显示文摘 | Stafford-Smith M Podgoreanu M Swaminathan M | 2005 | AmJ Kidney Dis2005，45，3： | 1 |
| 19 | Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion显示文摘 | Aslan T. Turer Robert D. Stevens James R. Bain Michael J. Muehlbauer Johannes van der Westhuizen Joseph P. Mathew Debra A. Schwinn Donald D. Glower Christopher B. Newgard Mihai V. Podgoreanu | 2009 | Circulation2009，，13： | 1 |
| 20 | Genetic Vari- ants in P - Selectin and C - Reactive Protein Influence Suscep- tibility to Cognitive Decline After Cardiac Surgery 显示文摘 | Mathew JP Podgoreanu MV Grocott HP | 2007 | J Am Coil Cardiol2007，49，19： | 1 |
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