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| 1 | Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury显示文摘Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no U.S.Food and Drug Administration-approved cure.Enolase,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in SCI.Enolase is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway activation.SCI-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in SCI.Enolase surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated kinase.Studies here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following SCI.Also,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase activity.The combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following SCI.The role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neurodegenerative diseases.Hence,this review discusses the importance of enolase activation and inhibition as a potential therapeutic target following SCI to promote neuronal survival and regeneration. | Hannah MMcCoy Rachel Polcyn Naren LBanik Azizul Haque | 2023 | Neural Regeneration Research2023，18，7： | 3 |
| 2 | Clinical diagnosis of oral erosive lichen planus by direct oral microscopy显示文摘 | Drogoszewska B Chomik P Polcyn A | 2014 | Postpy Dermatol Alergol2014，31，4： | 1 |
| 3 | Aerobic and anaerobic nitrate and nitrite reduction in free-living cells of Bradyrhizobium sp (Lupinus)显示文摘 | POLCYN W LUCINSKI R | 2003 | FEMS Microbiol Lett2003，226，2： | 1 |
| 4 | Experimental Investigation of Blast Wall Panels Undershock Pressure Loading 显示文摘 | SCHLEYER G K LOWAKB M J POLCYN M A | 2007 | International Journal of Impact Engineering2007，34，3： | 1 |
| 5 | Multistep charge transfers in stationary electrode polarography 显示文摘 | POLCYN D S SHAIN I | 1966 | Anal Chem1966，38，： | 1 |
| 6 | Cretaceous paleogeography,paleoclimatology,and ammonite biogeography of the low and mid-latitude South Atlantic Ocean显示文摘 | Jacobs L L Mateus O Polcyn M J | | 0，，04： | 1 |
| 7 | Metallopeptidases AVE, NEP and APN inhibition by plant extracts显示文摘 | KISS A POLCYN A | 2005 | Acta Poloniae Pharmaceutica Drug Research2005，62，4： | 1 |
| 8 | Influence of respiratory maneuvers on jugular venous reflux显示文摘 | Rao BK Polcyn RE Lieberman LM | | 0，，01： | 1 |
| 9 | Experimental investigation of blast wall panel under shock pressure loading 显示文摘 | Schleyer G K Lowak M J Polcyn M A | 2007 | International Journal of ImpactEngin-eering2007，34，： | 1 |
| 10 | Difficulties in diagnosing angiomatoid fibrous histiocytoma of the head and neck region:A case report显示文摘BACKGROUND Angiomatoid fibrous histiocytoma(AFH)is a rare,slow-growing soft tissue tumor.It appears mostly on the limbs and trunk in children and young adults.The biology of AFH remains unclear because of the small number of reported cases.Diagnostic testing does not provide definitive results.It has two clinical forms,that differ in terms of gene expression and clinical prognosis.It is important to inform the laboratory which specific gene testing is necessary.Here,we describe a case of rare AFH in the submandibular region using a full genetic panel.CASE SUMMARY A 13-year-old boy who had been misdiagnosed in the past 6 mo by his dentist visited our clinic because of a lesion in the submandibular area on the right side.The lesion was homogeneous and painless upon palpation.No skin discoloration was observed.Due to the non-specific radiological picture computed tomography(CT),magnetic resonance imaging(MRI),cone-beam CT(CBCT),and ultrasoundguided biopsy were performed.A venous malformation was suspected on the MRI.None of the tests provided a definitive diagnosis.Owing to the non-specific radiological findings,the patient qualified for surgical treatment.The surgical procedure included an excisional biopsy.The diagnostic testing was extended using gene rearrangements.The most distinctive gene translocation in diagnosing AFH is within the EWS RNA-binding protein 1(EWSR1)-CREB-binding protein.However,in this case,the diagnosis was confirmed by a rearrangement within the EWSR1 gene testing.CONCLUSION AFH in the submandibular location is rare,and surgical treatment with genetic evaluation defines AFH type that affects subsequent procedures. | Adam Michcik Marta Bień Barbara Wojciechowska Adam Polcyn Łukasz Garbacewicz Jacek Kowalski Barbara Drogoszewska | 2023 | World Journal of Clinical Cases2023，11，26： | 0 |
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