|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | Adsorption of benzotriazole on copper electrode surfaces in citric acid media 显示文摘 | Bastidas J M Pinilla P Polo J L | 2002 | Corrosion2002，58，11： | 1 |
| 4 | Learning in chemistry with virtual laboratories显示文摘 | Jimenez P M Pedrajas A P Polo J | 2003 | Journal of Chemieal Edueation2003，80，3： | 1 |
| 5 | Buyer power and quality improvements显示文摘 | BATTIGALLI P FUMAGALLI C POLO M | 2007 | Research in Eco- nomics2007，61，2： | 1 |
| 6 | Montelukast Reduces Asthma Exacerbations in 2 to 5 year old Children with Intermittent Asthma 显示文摘 | Bisgaard H Zielen S Garcia-Garcia L Johnston SL Gilles L Menten J Tozzi CA Polos P | 2004 | Am J Respir Crit Care Med2004，171，4： | 1 |
| 7 | When does estrogen replacement therapy improve sleep quality?显示文摘 | Polo KANTOLA P ERKKOLA R HELENIUS H | 1998 | Am J Obstet Gynecol1998，178，5： | 1 |
| 8 | The effect of estrogen replacement therapy on cardiac regulation显示文摘 | Virtanen I Polo O Polo-Kantola P | 2000 | Maturitas2000，37，1： | 1 |
| 9 | Adsorption of benzotriazole on copper electrode surface in citric acide midia 显示文摘 | Bastidas J M Pinilla P Polo J L | 2002 | Corrosion2002，58，11： | 1 |
| 10 | Effect of TGF-beta2 on proliferative scar fibroblast cell kinetics 显示文摘 | Polo M Smith P D Kim Y J | 1999 | Ann Plast Surg1999，43，2： | 1 |
| 11 | Formation of biogenic amines throughout the in- dustrial manufacture of red wine 显示文摘 | MARCOBAL A MARTIN-ALVAREZ P J POLO M C | 2006 | Journal of Food Protection2006，69，2： | 1 |
| 12 | Efficacy of growth factors in the accelerated closure of interstices in explanded mesh human skin grafts 显示文摘 | SMITH P D POLO M SOLER P M | 2000 | Burn Care Rehabil2000，21，： | 1 |
| 13 | Surgical fixation of rib frac- tures with clips and titanium bars( STRATOS System) 显示文摘 | MORENO DE LA SANTA BARAJAS P POLO OTERO MD DEL- GADO S~tNCHEZ-GRACI~tN C | 2010 | Prelim- inary experience Cir Esp2010，88，3： | 1 |
| 14 | Phage-display of antigenic peptides applied to vaccine design 显示文摘 | Fanutti C Del Polo G De Berardinis P | 1998 | Biochem Soc T1998，26，1： | 1 |
| 15 | When ubi- quitin meets ubiquitin receptors:a signalling connection显示文摘 | di FIORE P P POLO S HOFMANN K | 2003 | Nat Rev Mol Cell Biol2003，4，6： | 1 |
| 16 | Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas显示文摘 | Polo J M Juazczynski P Monti S Cerchietti L Ye K Greally J M | | 0，，： | 1 |
| 17 | Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double- blind crossover trial in postmenopausal women显示文摘 | Polo K P Erkkola R Irjata K | 1999 | Fertil Steril1999，71，5： | 1 |
| 18 | Endocytosis and cancer 显示文摘 | Polo S Pece S Di Fiore P P | 2004 | Curr Opin Cell Biol2004，16，2： | 1 |
| 19 | Adsorption of benzotriazole on copper electrode surfaces in citric acid media显示文摘 | Bastidas J M Pinilla P Polo J L | 2002 | Corrosion2002，58，11： | 1 |
| 20 | Treatment of acute respiratory failure with non-invasive intermittent positive pressureventilation in haematological patients 显示文摘 | Tognet E Mercatello A Polo P | 1994 | Clin Intensive Care1994，5，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员