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31篇 您的检索式:作者名="Pongor"
    题名 作者 年代 出处 被引量
1α-淀粉酶抑制剂AAI的核磁共振氢谱谱峰归属及结构分析显示文摘α -淀粉酶抑制剂AAI(α -AmylaseInhibitor)是从墨西哥苋属植物Amaranthushypochondriacus种子中提取的由32个氨基酸残基组成的多肽。它能强烈地抑制几种昆虫幼虫的α -淀粉酶活性 ,而不抑制人及哺乳类动物的α -淀粉酶活性。使用核磁共振方法收集了AAI的二维氢谱谱图 ,完成了全部主链和绝大部分侧链质子共振峰的序列归属 ,并利用X -PLOR软件计算出AAI的三维结构。AAI由三股反平行 β-折叠片与三对二硫键组成抑制剂胱氨酸结模体(inhibitorcystine -knotmotif)结构,与来自虎纹捕鸟蛛的神经毒素HWTX -I和凝集素SHL -I及其它来源的多种小分子活性多肽的结构类似 ,但它们的生物活力各不相同 ,表明该模体适用于结构功能关系的比较研究和作为蛋白质工程活力改造的结构骨架 (scaffold)。AAI对昆虫α -淀粉酶具有专一活性 ,可用于通过转基因技术来赋予植物抗虫活性。邓鹏翅 吕善运 罗静初 Sandor Pongor 刘修才 曲红 梁宋平 韩汝珊 顾孝诚 2000生物物理学报2000,16,3:7
2The efficiency of multi-target drugs:the network approach might help drug design显示文摘Csermely P Agoston V Pongor S 0,,04:1
3The efficiency of multi-target drugs:the network approach might help drug design显示文摘Csermely P Agoston V Pongor S 2005Trends Pharmacol Sci2005,26,4:1
4Repeats with variations: accelerated evolution of the Pin2 familyof proteinase inhibitors 显示文摘Barta E Pintar A Pongor S 2002Trends-in-Genetics2002,18,12:1
5The effi- ciency of multi-target drugs:the network approach might help drug design 显示文摘CSERMELY P AGOSTON V PONGOR S 2005Trends in Pharmacological Scienc- es2005,,4:1
6Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example显示文摘Agoston V Csermely P Pongor S 2005Phys Rev E2005,71,05:1
7Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection显示文摘G. Sipos K. Altdorfer é. Pongor L. P. Chen E. Fehér 2006Digestive Diseases and Sciences2006,,10:1
8The efficiency of multi-target drugs: the network approach might help drug design 显示文摘CSERMELY P AGOSTON V PONGOR S 2005Trends Pharmacol Sci2005,26,4:1
9Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example 显示文摘AGOSTON V CSERMELY P PONGOR S 2005Phys Rev E Stat Nonlin Soft Matter Phys2005,71,05:1
10The efficiency of multitarget drugs: the network approach might help drug design 显示文摘Csermely P Agoston V Pongor S 2005Trends Pharmacol Sci2005,26,:1
11The efficency of multi-target drugs:the network approach might help drug design 显示文摘Csermely P Agoston V Pongor S 2005Trends Pharmacol Sci2005,26,4:1
12Atom Depth as a Descriptor of the Protein Interior显示文摘Pintar A Carugo O Pongor S 2003Biophysical2003,84,4:1
13Neuroimmunomodulation in human autoimmune liver disease显示文摘Erzsébet Fehér éva Pongor Károly Altdorfer László Kóbori Gabriella Lengyel 2013Cell and Tissue Research2013,,2:1
14The efficiency of multitarget drugs: the network approach might help drug design 显示文摘Csermely P Agoston V Pongor S 2005Trends Pharmacol Sci2005,26,:1
15The efficiency of multi-target drugs: the network approach might help drug design显示文摘Csermely P goston V Pongor S 2005Trends Pharmacol Sci2005,26,4:1
16Scaled quantum mechanical (SQM) force field and vibrational assignment for styrene 显示文摘Hargitai R Szalay P G Pongor G 1994J Mol Struct (Theochem)1994,112,:1
17The ef- ficiency of multi-target drugs:the network approach might help drug design 显示文摘Peter Csermely Vilmos Agoston Sandor Pongor 2005Trends Pharmacol Sci2005,26,4:1
18Protein fold similarity estimated by a probabilistic approach based on Cα -Cα distance comparison 显示文摘Oliviero Carugo Sandor Pongor 2002J Mol Biol2002,315,4:1
19The efficiency of multi-target drugs: the network approach might help drug design显示文摘Csermely P Agoston V Pongor S 2005Trends Pharmacol Sci2005,26,:1
20Repeats with variations:accelerated evolution of the Pin2 family of proteinase inhibitors显示文摘Barta E Pintar A Pongor S N 2002Trends Genet2002,18,:1
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