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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO‐EpiCom Study of 209 pregnant women显示文摘 | N. Pedersen A. Bortoli D. Duricova R. D′Inca M. R. Panelli J. P. Gisbert G. Zoli A. López‐Sanromán F. Castiglione G. Riegler V. Annese P. Gionchetti A. Prada E. D. Pont A. Timmer C. Felley M. Shuhaibar E. V. Tsianos C. Dejaco F. J. Baert T. Jess M. Lebech | 2013 | Aliment Pharmacol Ther2013，，5： | 2 |
| 3 | Unified Method for the Prediction of Rain Attenuation in Satellite and Terrestrial Links显示文摘 | DA SILVA MELLO L PONTES M S | 2012 | Journal of Microwaves Optoelectronics and Electromagnetic Applications2012，11，1： | 1 |
| 4 | The effect of colchicine on liver function tests and hepatic fibrosis in patients with chronic active hepatitis:a study of 3 cases(author's transl)显示文摘 | Leandro P Ade O e Silva A BrandSo J F Saldanha L B Pontes J F | 2013 | Arquivos de Gastroenterologia2013，15，3： | 1 |
| 5 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 6 | START : a lipid - binding domain in STAR, HD - ZIP and signalling proteins 显示文摘 | Ponting CP Aravind L | 1999 | Trends Bio- chem Sci1999，24，4： | 1 |
| 7 | Leaf traits affect the above-ground productivity and quality of pasture grasses显示文摘 | Pontes L D Soussana J F Louault F | 2007 | Functional Ecology2007，21，5： | 1 |
| 8 | Polymeric precursor method to the synthesis of XWO4(X = Ca and Sr)thin films-structural,micro-structural and spectroscopic investigations显示文摘 | Pontes F M Galhiane M S Santos L S Petit L A Kataoka F P Mabuchi G H Longo E Zampieri M Pi-zani P S | 2009 | Journal of Alloys and Compounds2009，477，12： | 1 |
| 9 | Pressure - induced formation of inactive triple - shelled rotavirus particles is associated with changes in the spike protein VP4显示文摘 | Pontes L Cordeiro Y Giongo V | 2001 | J Mol Biol2001，307，5： | 1 |
| 10 | Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human Ulnar Mammary syndrome显示文摘 | Daven pont T G Jerome Majewska L A Papaioannou V E | 2003 | Development2003，130，10： | 1 |
| 11 | The GAF domain: an evo- lutionary link between diverse phototransducing proteins显示文摘 | Aravind L Ponting CP | 1997 | Trends Biochem Sei1997，22，： | 1 |
| 12 | Storage temperature effect on histamine formation in big eye tuna and skipjack显示文摘 | SILVA C C G da PONTE D J B DAPKEVICIUS M L N | 1998 | Journal of Food Science1998，63，4： | 1 |
| 13 | The new bilaterallypedicled V-Y advancement flap for face reconstruction 显示文摘 | Pontes L Ribeiro M Vrancks J J | 2002 | Plast Reconstr Surg2002，109，6： | 1 |
| 14 | Evolution and functions of long noncoding RNAs显示文摘 | PONTING C P OLIVER P L REIK W | 2009 | Cell2009，136，4： | 1 |
| 15 | Application of a temperature-dependent von Bertalanffy growth model to bullhead(Cottusgobio)显示文摘 | Kielbassa J Ddlignette-Muller M L Pont D | 2010 | Ecol Model2010，221，20： | 1 |
| 16 | History and future of the Multidisciplinary Association for Psychedelic Studies(MAPS)显示文摘 | Emerson A PontéL Jerome L | 2014 | J Psychoact ive Drugs2014，，： | 1 |
| 17 | Steels for ballistic protection 显示文摘 | Sangoy L Meunier Y Pont G | 1988 | Israel Journal of Technology1988，24，： | 1 |
| 18 | Vitamin K epoxide reductase:homology,active site and catalytic mechanism显示文摘 | Goodstadt L Ponting CP | 2004 | Trends Biochem Sci2004，29，6： | 1 |
| 19 | Rainwater chemistry and wet deposition over the equatorial forested ecosystem of Zoetele (Cameroon) 显示文摘 | Sigha-Nkamdjou L Galy Lacaux C Pont V | 2003 | Journal of Atmospheric Chemistry2003，，46： | 1 |
| 20 | START:a lipid-binding domain in StAR,HD-ZIP and signalling proteins显示文摘 | Ponting C P Aravind L | 1999 | Trends Biochem Sci1999，24，： | 1 |
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