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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Evaluation of avidin-biotin ELISA for the detection of antibodies to goat poxvirus using noninfections diagnostic reagent显示文摘 | RAO T V S POONAM MALIK ASGOLA D | 1999 | Acta-Virologica1999，43，5： | 1 |
| 3 | Punicalagins-A large polyphenol compo unds found in pomegranate:A therapeutic review显示文摘 | Satyanand T Ajeet S Poonam B | 2012 | J Plant Sci2012，5，2： | 1 |
| 4 | Punicalagins-A large polyphenol compounds found in pomegranate:A therapeutic review显示文摘 | Satyanand T Aject S Poonam B | 2012 | Plant Sci2012，5，2： | 1 |
| 5 | Tissue culture studies of to- mato (Lycopersicon esculentum)显示文摘 | Poonam B Nanjappa A Senaratna T | 2004 | Plant Cell Tissue and Organ Culture2004，78，： | 1 |
| 6 | Analysis of genetic and epigenetic variation in in vitro propagated potato somatic hybrid by AFLP and MSAP marker显示文摘 | Jagesh K T Shaumaya S Poonam C | 2013 | Electron J Biotechn2013，16，6： | 1 |
| 7 | Vaccination with DNA encoding ORFF antigen confers protective immunity in mice infected with Leishmania donovani显示文摘 | Bindu S Poonam T Shailendra S | 2003 | Vaccine2003，21，1112： | 1 |
| 8 | Punicalagins-A large polyphenol compounds found in pomegranate:A therapeutic review显示文摘 | Satyanand T Ajeet S Poonam B | | 0，，02： | 1 |
| 9 | Genetic analysis of oleic acid and linoleic acid content in Indian mustard 显示文摘 | CHAUHAN J S TYAGI M K POONAM T | 2002 | SABRAO Journal of Breeding and Genetics2002，34，2： | 1 |
| 10 | Zassenhaus conjecture forA5显示文摘 | Luthar I Poonam T | | 0，，08： | 1 |
| 11 | NMR spectrosco- py based metabolic profiling of urine and serum for inves- tigation of physiological perturbations during radiation sickness显示文摘 | Ahmad R K Poonam R Ritu T | 2011 | Metabolomics2011，7，： | 1 |
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