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| 1 | Insights into platinum-induced peripheral neuropathy–current perspective显示文摘Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment. | Andrijana Lazić Jelena Popović Tatjana Paunesku Gayle EWoloschak Milena Stevanović | 2020 | Neural Regeneration Research2020，15，9： | 2 |
| 2 | Learning physics-based motion style with nonlinear inverse optimization显示文摘 | Liu C Karen Hertzmann Aaron Popovi(c) Zoran | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 3 | Clinical evaluation of functional eleetrial therapy in acute hemiplegic subjects显示文摘 | Popovic MB Popovie DB Sinkjaer T | 2003 | J Rehabil Res Dev2003，40，： | 1 |
| 4 | Automatic rigging and animation of 3D characters显示文摘 | Ilya Baran Jovan Popovi? | 2007 | ACM Transactions on Graphics (TOG)2007，，3： | 1 |
| 5 | Novel cancer-targeting SPECT/NIRF dual-modality imaging probe (99m)Tc-PC-1007 : synthesis and biological evaluation 显示文摘 | Zhang Y Xiao L Popovie K | 2013 | Bioorg Med Chem Lett2013，23，23： | 1 |
| 6 | Analysis of the concrete strength versus ultrasonic pulse velocity relationship 显示文摘 | Popovies S | 1989 | Materials Evaluation1989，，2： | 1 |
| 7 | Age related progressive brachial artery endothelial dysfunction precedes the changed carotid and left ventricular geometry in healthy humans显示文摘 | Djuric D Popovie Z Petrovie J | 1999 | Angiology1999，50，7： | 1 |
| 8 | Nondestructive evaluation: past, present, and future 显示文摘 | Popovies John S | 2003 | Journal of Materials in Civil Engineering2003，15，3： | 1 |
| 9 | A numerical approach to the complete stress-strain curves for concrete 显示文摘 | Popovis S | 1973 | Cement and Concrete Research1973，3，5： | 1 |
| 10 | Longitudinal rotation : an unreeognised motion pattern in patients with dilated eardiomyopa- thy显示文摘 | Popovi ZB Grimm RA Ahmad A | 2008 | Heart2008，94，3： | 1 |
| 11 | Advances in functional electrical stimulation (FES) 显示文摘 | Popovi DB | 2014 | J Electromyogr Kinesiol2014，24，6： | 1 |
| 12 | High Mobility Group B1 Pro- tein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists 显示文摘 | Popovie PJ DeMareo R Lotze MT | 2006 | J Imnmno12006，177，12： | 1 |
| 13 | Adaptation of performed ballistic motion显示文摘 | Adnan Sulejmanpa?i? Jovan Popovi? | 2005 | ACM Transactions on Graphics (TOG)2005，，1： | 1 |
| 14 | Mitotic count, brain inva- sion, and Iocatin are independent prdictors of recun'ence-freesurvival in primary atypie',d and malignant meningiomas: a study of 86 patients 显示文摘 | Vranic A Popovi M Cot A | 2010 | Neurosurgery2010，67，： | 1 |
| 15 | Neuroproteetive effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimers disease in rats显示文摘 | Popovi M Caballero - Bleda M Popovi N | 1997 | Int J Neurosci1997，92，12： | 1 |
| 16 | The space of human body shapes:reconstruction and parameterization from range scans显示文摘 | Allen B Curless B Popovi?Z | | 0，，： | 1 |
| 17 | Determi- nation of Insulation Ageing and Operating Life Remainder of Transformers in Hydroelectric Power Plant Derdap I as a Factor Affecting the Increase of Their Rating显示文摘 | Radosavljevi R Bojkovi A Popovi A M | 2005 | Elektro- privreda2005，8，3： | 1 |
| 18 | Predictors of left ventricular thrombus formation and disappearance after anterior wall myocardial infarction显示文摘 | Neskovi'c A N Marinkovi'c J Boji'c M Popovi'c A D | 1998 | Eur Heart J1998，19，： | 1 |
| 19 | Peroxisome proliferator activated re-ceptor (PPAR ) gamma can inhibit chronic renal allogreft damage 显示文摘 | Kiss E Popovie ZV Bedke J | 2010 | Am J Pathol2010，176，5： | 1 |
| 20 | Impact of mitral regurgitation on reverse re- modeling and outcome in patients undergoing cardiac resynchronization therapy 显示文摘 | Verhaert D Popovi c ZB De S | 2012 | Cire Cardiovasc Imaging2012，5，1： | 1 |
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