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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy显示文摘 | WADHWA P D PORTO M GARITE T J | 1998 | Am J Obstet Gynecol1998，179，4： | 1 |
| 4 | Placental Corticotropin-releasing hormone (CRH),spontaneous preterm birth,and fetal growth restriction:a prospective investigation显示文摘 | Wadhwa PD Garite TJ Porto M | 2004 | Am J Obstet Gynecol2004，191，4： | 1 |
| 5 | Analysis of o- mega 3 fatty acid in natural and enrich chicken eggs by capillary zone electrophoresis 显示文摘 | Porto B L Souza M N Oliveira M A | 2011 | Analytical Sciences2011，27，5： | 1 |
| 6 | Smoothmusde cells in human atheroscle-rotic plaques secrete and proliferate in response to high mobility group box 1 protein显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB J2006，20，： | 1 |
| 7 | The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection 显示文摘 | Di Cristina M Del Porto P Buffolano W | 2004 | Microbes Infect2004，6，2： | 1 |
| 8 | Optimal location of control valves in pipe networks by genetic algorithm显示文摘 | REIS L F R PORTO R M | 1997 | ASCE Journal of Water Resources Planning and Management1997，123，6： | 1 |
| 9 | Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds显示文摘 | Fonseca A M Pereira C F Porto G | 2003 | Cellular Immunology2003，224，1： | 1 |
| 10 | Performance of low-cost ejectors 显示文摘 | Neto I E L Porto R D M | 2004 | Journal of Irrigation and Drainage Engineering2004，130，2： | 1 |
| 11 | Smooth muscle cells in human atherosclerotic plaques secrete and proliferate in response to high mobility group box 1 protein 显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB2006，20，14： | 1 |
| 12 | Angiographic as- sessment of microvascular perfusion-myocardial blush in clinical practice显示文摘 | Porto I Hamilton Craig C Brancati M | 2010 | Am Heart J2010，160，6： | 1 |
| 13 | Placental Corti- cotropin-Releasing Hormone (CRH), Spontaneous Preterm Birth, and Fetal Growth Restriction: A Prospective Investiga- tion显示文摘 | Wadhwa P D Garite T J Porto M | 2004 | Am J Obstet Gynecol2004，191，4： | 1 |
| 14 | Nickel induces oxidative burst, NF-kB activation and interleukin-8 production in human neutrophils显示文摘 | Freitas M Gomes A Porto G | 2010 | J Biol Inorg Chem2010，15，8： | 1 |
| 15 | Optimal location of control valves in pipe networks by genetic algorithm显示文摘 | Reis L F R Porto R M Chaudhry F H | 1997 | Water Resource Planning Management1997，123，6： | 1 |
| 16 | Management of NSAID-induced gastrointestinal toxicity:focus on proton pump inhibitors显示文摘 | Lazzaroni M Porto G B | 2009 | Drugs2009，69，1： | 1 |
| 17 | Spontaneous resolution of eosinophilic granuloma in a patient with a psychotic disorder 显示文摘 | Conforti R Porto A Cirillo M | 2010 | Neuroradiol J2010，23，4： | 1 |
| 18 | Smooth muscle ceils in human athero-sclerotic plaques secrete and imoliferate in response to high mobility group box l protein 显示文摘 | Porto A Palumbo R Pieroni M | | FASEB0，20，14： | 1 |
| 19 | Studies of graded cemented carbides eomponents显示文摘 | Rosso M Porto G Geminiani A | 1999 | Intemational Journal of Refractory Metals & Hard Materials1999，17，13： | 1 |
| 20 | Microbial reduction of cyclohexanones显示文摘 | de Conti R M Porto A L M Augusto J | 2001 | Journal of Molecular Catalysis B:Enzymatic2001，11，4： | 1 |
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