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| 1 | Nonalcoholic fatty liver disease and vascular disease:State-of-the-art显示文摘Nonalcoholic fatty liver disease(NAFLD), the most common of chronic liver disease in Western Country, is closely related to insulin resistance and oxidative stress and includes a wide spectrum of liver diseases ranging from steatosis alone, usually a benign and non-progressive condition, to nonalcoholic steatohepatitis(NASH), which may progress to liver fibrosis and cirrhosis. NAFLD is considered the hepatic manifestation of the metabolic syndrome with which shares several characteristics, however recent data suggest that NAFLD is linked to increased cardiovascular risk independently of the broad spectrum of risk factors of metabolic syndrome. Accumulating evidence suggests that the clinical burden of NAFLD is not restricted to liver-related morbidity and mortality, with the majority of deaths in NAFLD patients related to cardiovascular disease and cancer and not to the progression of liver disease. Retrospective and prospective studies provide evidence of a strong association between NAFLD and subclinical manifestation of atherosclerosis(increased intima-media thickness, endothelial dysfunction, arterial stiffness, impaired left ventricular function and coronary calcification). A general agreement emerging from these studies indicates that patients with NASH are at higher risk of cardiovascular diseases than those with simple steatosis, emphasizing the role of chronic inflammation in the pathogenesis of atherosclerosis of these patients. It is very likely that the different mechanisms involved in the pathogenesis of atherosclerosis in patients with NAFLD have a different relevance in the patients according to individual genetic background. In conclusion, in the presence of NAFLD patients should undergo a complete cardiovascular evaluation to prevent future atherosclerotic complications. Specific lifestyle modification and aggressive pharmaceutical modification will not only reduce the progression of liver disease, but also reduce morbidity for cardiovascular disease improving overall prognosis and survival. | Silvia Fargion Marianna Porzio Anna Ludovica Fracanzani | 2014 | World Journal of Gastroenterology2014，20，37： | 23 |
| 2 | Digital control and simulation for power electronic apparatus in dualvoltage railway locomotive 显示文摘 | Busco B Marino P Porzio M | 2003 | IEEE Transactions on Power Electronics2003，18，5： | 1 |
| 3 | The Gly 972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells显示文摘 | Porzio O Federici M Hribal ML | 1999 | J Clin Invest1999，104，3： | 1 |
| 4 | The Gly->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells显示文摘 | Hribal ML Federici M Porzio O | 2000 | J Clin Endocrinol Metab2000，85，5： | 1 |
| 5 | Physical exercise and quality of life in breast cancer survivors 显示文摘 | Valenti M Porzio G Aielli F | 2008 | Intenl J Med Sci2008，5，1： | 1 |
| 6 | Short-term weekly neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer显示文摘 | G Porzio C Ficorella G Toro | 2001 | Tumori12001，87，1： | 1 |
| 7 | The Gly/' Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells显示文摘 | HRIBAL M L FEDERICI M PORZIO 0 | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 8 | Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation显示文摘 | Stefano Rizza Marina Cardellini Eugenio Martelli Ottavia Porzio Chiara Pecchioli Antonio Nicolucci Nikolaus Marx Davide Lauro Arnaldo Ippoliti Franco Romeo Renato Lauro Massimo Federici | 2010 | Atherosclerosis2010，，1： | 1 |
| 9 | Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus显示文摘 | Colombo C Porzio O Liu M | 2008 | JClinInvest2008，118，6： | 1 |
| 10 | Epigenetic factors and midbrain dopaminergic neurone development 显示文摘 | Perrone-Capano C di Porzio U | 1996 | Bioessays1996，18，10： | 1 |
| 11 | Short-term weekly neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer 显示文摘 | Porzio G Ficorella C Toro G | 2001 | Tumori2001，87，1： | 1 |
| 12 | Shoa-tema weekly neo-adjuvant chemotherapy in the treatment of locally advanced cervicalcancer显示文摘 | Porzio G Ficorella C Torn G | 2001 | Tumor2001，87，1： | 1 |
| 13 | Pre-filtering improves reliability of Affymetrix GeneChips results when used to analyze gene expression in complex tissues显示文摘 | Greco D Leo D di Porzio U | 2008 | Molecular and Cellular Probes2008，22，2： | 1 |
| 14 | Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy 显示文摘 | Colucci- D'Amato L di Porzio U | 2008 | Bioessays2008，30，2： | 1 |
| 15 | Octreotide for malignant bowel obstruction twenty years after显示文摘 | Mercadante S Porzio G | 2012 | Crit Rev Oncol Hematol2012，83，3： | 1 |
| 16 | GLUT2and glucokinase expression is coordinately regulated by sulfonylurea显示文摘 | PORZIO O MARLIER LN FEDERICI M | 1999 | Mol Cell Endocrinol1999，153，12： | 1 |
| 17 | The Gly972→Arg972amino acid polymorphoism in IRS-1 affects glucose metabolism in skeletal muscle cells显示文摘 | HRIBAL M L FEDETICI M PORZIO O | 2000 | J Clin Endocrinol Metal2000，85，： | 1 |
| 18 | γ-isotactic polypropylene a structure with nonparallel chain axes 显示文摘 | Meille S V Bruckner S Porzio W | 1990 | Macromolecules1990，23，18： | 1 |
| 19 | The eff- ects of low doses of pregahalin on morphine analgesia in ad- vanced cancer patients 显示文摘 | MERCADANTE S PORZIO G AIELLI F | 2013 | Clin J Pain2013，29，1： | 1 |
| 20 | Tapentadol in cancer pain management:A prospective open-label study显示文摘 | Mercadante S Porzio G Ferrera P | 2012 | Curr Med Opin2012，28，11： | 1 |
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