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9篇 您的检索式：作者名="Povedano A"

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		题名	作者	年代	出处	被引量
	1	Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability.	Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas	2021	Engineering2021，7，10：	1
	2	Endoscopic treatment of central airway stenosis: five years' experience显示文摘	Cosano Povedano A Mufioz Cabrera L Cosano Povedano F J	2005	Arch Bronconeumol2005，41，6：	1
	3	Endoscopic Treatment of Central Airway Stenosis:Five Years' experience显示文摘	COSANO POVEDANO A MUNOZ CABRERA L COSANO POVEDANO FJ	2005	Arch Bronconcumol2005，41，6：	1
	4	Endoscopic treatment of central airway stenosis:five years'experience显示文摘	COSANO P A MUNOZ C L COSAN0 POVEDANO F J	2005	Arch Bronconeumol2005，41，：	1
	5	Endoscopic treatment of central airway stenosis:five years' experience显示文摘	Cosano Povedano A Mu(n)oz Cabrera L Cosano Povedano F J	2005	Archivos de Bronconeumologia2005，41，：	1
	6	Endoscopic treatment of central airway stenosis:five years'experience显示文摘	COSANO POVEDANO A MUNOZ CABRERA L COSANO POVEDANO F J	2005	Arch Bronconeumol2005，41，：	1
	7	Endoscopic treatment of central airway stenosis:five years experience显示文摘	Cosano Povedano A Munoz Cabrera L Cosano Povedano F J		0，，06：	1
	8	Endoscopic treatment of central airway stenosis:five years experience显示文摘	Cosano Povedano A Munoz Cabrera L Rubio Sanchez J	2005	Arch Bronconeumol2005，41，6：	1
	9	Orbicularis oris muscle:A doublebreasted suture for its repair in the unilateral cleft lip显示文摘	Povedano A	1991	Ann Plast Surg1991，27，：	1

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