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	题名	作者	年代	出处	被引量
1	Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones.	Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo	2001	World Journal of Gastroenterology2001，7，2：	2
2	Levels and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in superficial sediment from 15 Italian marine protected areas (MPA) 显示文摘	Perra G Pozo K Guerranti C	2011	Marine pollution bulletin2011，62，4：	1
3	Levels and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in sediments from Lenga Estuary, central Chile显示文摘	Pozo K Perra G Menchi V	2011	Marine pollution bulletin2011，62，7：	1
4	Characterization of a natural larger form of the antifungal protein (AFP) from Aspergillus giganteus显示文摘	Martinez-Ruix A Martinez del Pozo A Lacadena J Mancheno J M Onaderra M Gavilanes J G	1997	Biochim Biophys Acta1997，1340，1：	1
5	Monitoring changes in the volatile profile of cheese crackers during storage using GC-MS and PTR-MS显示文摘	POZO BAYON M A MARTIN ALVAREZ P J REINECCIUS G A	2009	Flavour and Fragrance Journal2009，24，3：	1
6	Increased regulatory T cell counts in HIV- infected nonresponders to hepatitis B virus vaccine 显示文摘	del Pozo Balado Mdel M Leal M Mendez Lagares G	2010	J Infect Dis2010，202，3：	1
7	Exact analytical solution of a two diode circuit model for organic solar cells showing S-shape using Lambert W-functions显示文摘	Romero B Del POZO G ARREDONDO B	2012	Solar Energy2012，，86：	1
8	Rate of blood loss over 48 hours following total knee replacement显示文摘	Senthil Kumar G Von Arx OA Pozo JL	2005	Knee2005，12，4：	1
9	Differential effects of 1-Methylcyclopropene on citrus leaf and mature fruit abscission显示文摘	POZO L YUAN R C KOSTENYUK I FERNANDO A ZHONG G Y BURNS J K	2004	Physiol Plant2004，129，4：	1
10	Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep显示文摘	Edul V S Ferrara G Pozo M O		0，，04：	1
11	IP08 and FBXLIO: new reference genes for gene ex- pression studies in human adipose tissue显示文摘	Hurtado del Pozo C Calvo RM Vesperinas-Garcia G	2010	Obesity ( Silver Spring)2010，18，5：	1
12	ChREBP expression in the liver,adipose tissue and differentiated preadipocytes in human obesity显示文摘	HURTADO Del POZO C VESPERINAS-GARCIA G RUBIO M A	2011	Biochim Biophys Acta2011，1811，12：	1
13	Radical Roles for RAGE in the Pathogenesis of Oxidative Stress inCardiovascular Diseases and Beyond显示文摘	Daffu G del Pozo CH O' Shea KM	2013	Int J Mol Sci2013，14，19：	1
14	Exact analytical solution ofa two diode circuit model for organic solar cells showing S-shape using Lambert W-functions显示文摘	Romero B Pozo G Arredondo B	2012	Solar Energy2012，86，：	1
15	Rate of blood loss over 48 hours following total knee replacement 显示文摘	Senthil Kumar G Von Arx OA Pozo JL	2005	Knee2005，12，4：	1
16	Rate of blood loss over 48 hours following total knee replacement 显示文摘	SenthiI-Kumar G Von Arx OA Pozo JL	2005	Kee2005，12，：	1
17	Host specificity of Phytophthora infestans on tomato and potato in Ecuador 显示文摘	Oyarzun P J Pozo A Ordonez M E Doucett K Forbes G A	1998	Phytopathology1998，88，3：	1
18	MAPKKKα is a positive regulator of cell death associated with both plant immunity and disease显示文摘	del Pozo O Pedley K F Martin G B	2004	EMBO J2004，23，：	1
19	Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel显示文摘	HERRERA G M POZO M J ZVARA P	2003	J Physiol2003，551，3：	1
20	Identification of ubiquitinated proteins in Arabidopsis显示文摘	Manzano M Abraham Z López-Torrejón G Del Pozo JC		0，，：	1

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