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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，1： | 1 |
| 3 | Contribution to piled raft foundation design显示文摘 | PRAKOSO W A KULHAWY F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，1： | 1 |
| 4 | Contribution to Piled Raft Foundation Design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnial and Geoenvironmental Engineering2001，127，1： | 1 |
| 5 | Contribution to piled raft foundation design显示文摘 | PRAKOSO WA KULHAWY FH | | Journal of Geotechnical and Geoenvironmental Engineering0，127，1： | 1 |
| 6 | Contribution to piled raft foundation design显示文摘 | PRAKOSO W A KULHAWY F H | 2001 | Journal of Geoteehnieal and Geoenvironmental Engineering2001，127，1： | 1 |
| 7 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kuthawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，1： | 1 |
| 8 | Contribution to Piled Raft Foundation Design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Jouranl of C eotechnical and Geoenvimnmental Engineering2001，127，1： | 1 |
| 9 | Contribution to piled raft foundation design 显示文摘 | PRAKOSO W A KULHAWY F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，117，2： | 1 |
| 10 | Combination adefovir- lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B显示文摘 | Poorten D Prakoso E Khoo TL | 2007 | J Gastroenterol Hepatol2007，22，9： | 1 |
| 11 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，1： | 1 |
| 12 | Contribution to Piled Raft Foundation Design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，117，2： | 1 |
| 13 | Contribution to piledraft foundation design显示文摘 | PRAKOSO W A KULHAWY F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，117，2： | 1 |
| 14 | Contribution to Piled Raft Foundation Design 显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，117，2： | 1 |
| 15 | Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B 显示文摘 | VAN DER POORTEN D PRAKOSO E KHOO TL | 2007 | J Gastroenterol Hepatol2007，22，9： | 1 |
| 16 | Hepatocellular carcinoma incidence post direct-acting antivirals in hepatitis C-related advanced fibrosis/cirrhosis patients in Australia显示文摘Background:Despite efficacy in HCV eradication,direct-acting antiviral(DAA)therapy has raised controversies around their impact on hepatocellular carcinoma(HCC)incidence.Herein we reported the first Australian data on HCC incidence in DAA-treated HCV patients with advanced fibrosis/cirrhosis.Methods:We conducted a retrospective single center study of DAA-treated HCV patients with advanced fibrosis/cirrhosis from April 2015 to December 2017.Patients with prior HCC were included if they had complete response to HCC treatment.Results:Among 138 patients who completed DAA therapy,133(96.4%)achieved sustained virologic response(median follow-up 23.8 months).Ten had prior HCC and 5/10(50.0%)developed recurrence,while de novo HCC developed in 7/128(5.5%).Median time from DAA to HCC diagnosis was 34 weeks in recurrent HCC vs.de novo 52 weeks(P=0.159).In patients with prior HCC,those with recurrence(vs.without)had shorter median time between last HCC treatment and DAA(12 vs.164 weeks,P<0.001).On bivariate analysis,failed sustained virologic response at 12 weeks(SVR12)(P=0.011),platelets(P=0.005),model for end-stage liver disease(MELD)score(P=0.029),alpha fetoprotein(AFP)(P=0.013),and prior HCC(P<0.001)were associated with HCC post-DAA.On multivariate analysis,significant factors were prior HCC(OR=4.80;95%CI:1.47–48.50;P=0.010),failed SVR12(OR=2.83;95%CI:1.71–16.30;P=0.016)and platelets(OR=0.97;95%CI:0.95–0.99;P=0.009).Conclusions:Our study demonstrates a high incidence of recurrent HCC in HCV patients with advanced fibrosis/cirrhosis treated with DAA.Factors associated with HCC development post-DAA were more advanced liver disease,failed SVR12 and prior HCC,with higher rates of recurrence in those who started DAA earlier. | Patrick P Y Chan Miriam T Levy Nicholas Shackel Scott A Davison Emilia Prakoso | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 1 |
| 17 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kulawy F H | 2001 | Geolechnical Engineering2001，11，3： | 1 |
| 18 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，1： | 1 |
| 19 | The inability to visualize the ampulla of Vater is an inherent limitation of capsule endoscopy显示文摘 | Warwick S. Selby Emilia Prakoso | 2011 | European Journal of Gastroenterology & Hepatology2011，，1： | 1 |
| 20 | Contribution to piled raft foundation design显示文摘 | Prakoso W A Kulhawy F H | 2001 | Journal of Geotechnical and Geoenvironmental Engineerlng2001，127，1： | 1 |
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