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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Cerebral small - vessel disease and decline in information processing speed, executive function and memory显示文摘 | Prins ND van Dijk EJ den Heijer T | 2005 | Brain2005，128，9： | 1 |
| 3 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，，9： | 1 |
| 4 | Association between blood pressure,white matter lesions, and atrophy of the medial temporal lobe 显示文摘 | Den Heijer T Launer LJ Prins ND | 2005 | Neurology2005，64，2： | 1 |
| 5 | Application of DDRT-PCR to the analysis of differential gene expression in a plant-fungus interaction显示文摘 | Prins T van Kan J A | 1996 | Plant Molecular Biology1996，32，5： | 1 |
| 6 | Cerebral white matter lesions and the risk of dementia显示文摘 | Prins N D van Dijk E J den Heijer T | | 0，，10： | 1 |
| 7 | Tracking rodent - dispersed large seeds with passive integrated transponder ( PIT ) tags 显示文摘 | Suselbeek L Jansen P A Prins H H T | 2013 | Methods in Ecology and Evolution2013，4，6： | 1 |
| 8 | Cerebral small-vessel disease and decline in information processing speed, executive function and memory显示文摘 | Prins ND van Dijk EJ den Heijer T | 2005 | Brain2005，128，9： | 1 |
| 9 | Silent brain infarcts and the risk of dementia and cognitive decline显示文摘 | Vermeer SE Prins ND denHeijer T | | 0，，： | 1 |
| 10 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，1： | 1 |
| 11 | Minimum requirements for modeling bivalve carrying capacity 显示文摘 | Small A C Prins T C Bankers N | 1998 | Aquatic Ecology1998，31，： | 1 |
| 12 | Silent brain infarcts and the risk of dementia and cognitive decline显示文摘 | Vermeer S E Prins N D den Heijer T | 2003 | N Engl J Med2003，348，17： | 1 |
| 13 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 14 | Cerebral small-vessel disease and decliDe in information processing speed,executive function and memory显示文摘 | van Dijk EJ den Heijer T | 2005 | Brain2005，128，： | 1 |
| 15 | Association between blood pressure,white matter lesions,and atrophy of the medial temporal lobe显示文摘 | den Heijer T Launer LJ Prins ND | 2005 | Neurology2005，64，2： | 1 |
| 16 | Silicate availability,vertical mixing and grazing control of phytoplankton blooms in mesocosms显示文摘 | Escaravage V Prins T C | 2002 | Hydrobiologia2002，484，： | 1 |
| 17 | Predicting in situ pasture quality in the Kruger National Park, South Africa u sing continuum removed absorption features显示文摘 | Mutanga O Skidmore A K Prins H H T | 2004 | Remote Sens ing of Environment2004，89，3： | 1 |
| 18 | Silent brain infarcts and the risk of dementia and cognitive decline显示文摘 | Vermeer SE Prins ND den Heijer T | | 0，，： | 1 |
| 19 | Silent brain infarction and the risk of dementia and cognitive decline显示文摘 | Veneer SE Prins ND Den Heijer T | 2003 | N Engl J Med2003，348，： | 1 |
| 20 | Cerebral small-vessel disease and decline in information processing speed, executive function and memory显示文摘 | Prins ND van Dijk E J den Heijer T | 2005 | Brain2005，128，9： | 1 |
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