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| 1 | Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein显示文摘Background:Abnormal aggregation of brainα-synuclein is a central step in the pathogenesis of Parkinson’s disease(PD),thus,it is reliable to promote the clearance ofα-synuclein to prevent and treat PD.Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules,however,their pathophysiological aspects remain elusive.Method:Meningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes.Six weeks later,glymphatic functions and PD-like phenotypes were systemically analyzed.Results:Glymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice,accompanied with perivascular aggregation ofα-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra.Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice,causing more severe accumulation ofα-synuclein,glial activation,inflammation,dopaminergic neuronal loss and motor deficits.Conclusion:The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology. | Wenyan Zou Tinglin Pu Weixi Feng Ming Lu Ying Zheng Renhong Du Ming Xiao Gang Hu | 2019 | Translational Neurodegeneration2019，8，1： | 17 |
| 2 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 3 | Spatial Pattern Evolution and Casual Analysis of County Level Economy in Changsha-Zhuzhou-Xiangtan Urban Agglomeration, China显示文摘In order to evaluate whether or not the county units′ economy in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan) Urban Agglomeration was growing as expected, this study analyzed the spatial economy pattern at county-level by using the Exploratory Spatial Data Analysis(ESDA) method. In this process, the global Moran′s I and local Getis-Ord G*i indexes were employed to analyze indicators including per capita GDP and three industrials(i.e. primary, secondary and tertiary industry) from 2000 to 2010. The results show that: 1) the county units′ economy in the Chang-Zhu-Tan Urban Agglomeration has exhibited a strong spatial autocorrelation and an accelerated integration trend since 2008(Moran′ s I increased from 0.26 to 0.56); 2) there is a significant difference in economy development between the northern and southern county units in the Chang-Zhu-Tan Urban Agglomeration: the hotspot zone with high economic level was formed among the northern county units whereas the coldspot zone with low economic level was located in the southern areas. This difference was caused primarily by the increasingly prominent economic radiation effect of Changsha ′upheaval′; 3) town density, secondary industry, and the integration policy are the major contributors driving the evolution of the spatial economy pattern in the Chang-Zhu-Tan Urban Agglomeration. | DONG Minghui ZOU Bin PU Qiang WAN Neng YANG Lingbin LUO Yanqing | 2014 | Chinese Geographical Science2014，24，5： | 8 |
| 4 | Clinical Predictors of Outcome in Patients with Anti-neutrophil Cytoplasmic Autoantibody-related Renal Vasculitis: Experiences from a Single-center显示文摘 | Lei Pu Gui-Sen Li Yu-Rong Zou Ping Zhang Li Wang | 2017 | Chinese Medical Journal2017，，8： | 6 |
| 5 | Study on dynamic characteristics of fission products in 2 MW molten salt reactor显示文摘In this study,a numerical flow model of the fission products(FPs)in the primary loop system of a molten salt reactor(MSR)was established and solved using Mathematica 7.0.The simulation results were compared with those of the ORIGEN-S program in the static burnup mode,and the deviation was found to be less than 10%,which indicates that the results are in good agreement.Furthermore,the FPs distribution in the primary loop system under normal operating conditions of the 2 MW MSR was quantitatively analyzed.In addition,the distribution phenomenon of the FPs under different flow rate conditions was studied.At the end of life,the FPs activity in the core region(including active region,and upper and lower plenum regions)accounted for 77.3%,and that in the hot leg #1,main pump,hot leg #2,heat exchanger,and cold leg region accounted for 1.2%,16.15%,0.99%,2.5%,and 1.9%,respectively,of the total FPs in the primary loop under normal operating conditions.The proportion of FPs in the core decreased with the increase in flow rate in the range of 2.24-22,400 cm^3 s^-1.The established analytical method and conclusions of this study can provide an important basis for radiation safety design of the primary loop,radioactive source management design,thermal-hydraulic safety analysis,and radiochemical analysis of FPs of 2 MW MSRs. | Bo Zhou Xiao-Han Yu Yang Zou Pu Yang Shi-He Yu Ya-Fen Liu Xu-Zhong Kang Gui-Feng Zhu Rui Yan | 2020 | Nuclear Science and Techniques2020，31，2： | 3 |
| 6 | Ge nanoparticles uniformly immobilized on 3D interconnected porous graphene frameworks as anodes for high-performance lithium-ion batteries显示文摘Germanium(Ge), an alloy-type anode material for lithium-ion batteries(LIBs), possesses many advantages such as high theoretical capacity and decent electrical conductivity. Nevertheless, its application is restricted by tremendous volume variation and tardy reaction kinetic during discharge/charge process.In this paper, the Ge/3DPG composites with Ge nanoparticles uniformly dispersed in 3D interconnected porous graphene(3DPG) skeleton are successfully prepared using a template-assisted in-situ reduction method. The unique 3D interconnected porous graphene can not only enhance the electronic conductivity and reaction kinetics of the materials, but also provide sufficient buffer space to effectively mitigate the volume expansion during cycling and strengthen the structural integrity. Moreover, the small-sized Ge nanoparticles in close conjunction with the 3D graphene can boost the surface-controlled reaction of the electrode, which contributes to a fast charge–discharge rate capability. The Ge/3DPG composite with optimized Ge/graphene mass ratio delivers high reversible specific capacity(1102 mAh g^(-1) after 100 cycles at 0.2 C), outstanding rate capability(494 mAh g^(-1) at 5 C), and admirable cycling stability(85.3% of capacity retention after 250 cycles at 0.5 C). This work provides a significant inspiration for the design and fabrication of advanced Ge-based anode materials for next-generation highperformance LIBs. | Yao Chen Yuming Zou Xiaoping Shen Jingxia Qiu Jiabiao Lian Jinrui Pu Sheng Li Fei-Hu Du Shang-Qi Li Zhenyuan Ji Aihua Yuan | 2022 | Journal of Energy Chemistry2022，31，6： | 3 |
| 7 | A novel PIK3CD C896T mutation detected in bilateral sudden sensorineural hearing loss using next generation sequencing:An indication of primary immunodeficiency显示文摘Objective: To investigate immune-related genetic background in bilateral sudden sensorineural hearing loss(SSNHL).Case report and methods: The case is a 45-year-old man presenting with a 7-year history of bilateral profound SSNHL. Blood biochemical testing demonstrated increased levels of total cholesterol(5.88 mmol/L). Tests for hepatitis B showed a positive antibody against the hepatitis B core antigen. Complement C3 was below the normal value, and complement C4 and Ig G were in the lower range of normal values. CT images showed a normal inner ear and vestibular aqueduct but round window membranous ossification on both sides. A total number of 232 immuneassociated genes were sequenced using the next generation sequencing technique.Results: Mutations were detected in 5 genes, including the phosphoinositide 3-kinase catalytic subunit delta(PIK3CD), caspase recruitment domain-containing protein 9(CARD9), complement factor H-related(CFHR2), immunoglobulin lambda-like polypeptide 1 Protein(IGLL1),and transmembrane channel-like gene family 8(TMC8). In the PIK3 CD gene, a C896 T substitute in exon 7 was detected. This mutation causes primary immunodeficiency and is an autosomal dominant disease.Conclusion: The PIK3 CD C896T mutation responsible for primary immunodeficiency may contribute to the onset of bilateral SSNHL with subsequent rapid progression. | Jing Zou Xiangqiang Duan Guiliang Zheng Zhen Zhao Shiyue Chen Pu Dai Hongliang Zheng | 2016 | Journal of Otology2016，11，2： | 3 |
| 8 | Cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is generally believed to be caused by the production ofβ-amyloid protein(Aβ),and hyperphosphorylation of tau,which are deposited inβ-amyloid plaques(APs)and neurofibrillary tangles(NFTs),respectively.However,the inherent reasons for their propagation and deposition remain unknown.In light of our prior works,magnesium(Mg2+)deficiency is critical for the onset of AD.1 In addition,the restoration of Mg2+in the brain reduces neuroinflammation by suppressing the expression of interleukin(IL)-1β,1 which decreases Aβoverload in an APH-1α/1β-dependent mechanism.2 In this regard,inflammation is the target of Mg2+in the treatment of AD.In addition to IL-1β,a powerful inflammatory inducer,cyclooxygenase-2(COX-2),has also been reported to be inhibited by the addition of Mg2+.3 We thereby extended our prior works to COX-2.Analyses of the underlying mechanisms elucidated the role of COX-2 in spreading Aβdeposits in APs to the cerebellum.This was probably caused by the formation of hetero-oligomers between COX-2 and Aβ,which have been shown to accelerate the aggregation and deposition of Aβin APs.4 Moreover,the induction of COX-2 decreased the glycosylation of tau,which has been shown to result in the phosphorylation of tau in different animal models.In this scenario,the status of tau phosphorylation is critical for the development and progression of AD.5 Therefore,COX-2 appears to be a potential therapeutic target for AD. | Pei-Pei Guan Xin Yu Yan-Hui Zou Pu Wang | 2019 | Cellular & Molecular Immunology2019，16，11： | 3 |
| 9 | Neutronics analysis for MSR cell with different fuel salt channel geometries显示文摘The neutronic properties of molten salt reactors(MSRs)differ from those of traditional solid fuel reactors owing to their nuclear fuel particularity.Based on the Monte-Carlo N particle transport code,the effects of the size and shape of the fuel salt channel on the neutron physics of an MSR cell are investigated systematically in this study.The results show that the infinite multiplication factor(k?)first increases and then decreases with the change in the graphite cell size under certain fuel volume fraction(FVF)conditions.For the same FVF and average chord length,when the average chord length is relatively small,the k?values for different fuel salt channel shapes agree well.When the average chord length is relatively large,the k?values for different fuel salt channel shapes differ significantly.In addition,some examples of practical applications of this study are presented,including cell selection for the core and thermal expansion displacement analysis of the cell. | Shi-He Yu Ya-Fen Liu Pu Yang Rui-Min Ji Gui-Feng Zhu Bo Zhou Xu-Zhong Kang Rui Yan Yang Zou Ye Dai | 2021 | Nuclear Science and Techniques2021，32，1： | 2 |
| 10 | Study on neutronics design of ordered-pebble-bed fluoride-salt- cooled high-temperature experimental reactor显示文摘This paper presents a neutronics design of a 10 MW ordered-pebble-bed fluoride-salt-cooled high-temperature experimental reactor. Through delicate layout, a core with ordered arranged pebble bed can be formed,which can keep core stability and meet the space requirements for thermal hydraulics and neutronics measurements.Overall, objectives of the core include inherent safety and sufficient excess reactivity providing 120 effective full power days for experiments. Considering the requirements above, the reactive control system is designed to consist of 16 control rods distributed in the graphite reflector. Combining the large control rods worth about 18000–20000 pcm, molten salt drain supplementary means(-6980 to -3651 pcm) and negative temperature coefficient(-6.32 to -3.80 pcm/K) feedback of the whole core, the reactor can realize sufficient shutdown margin and safety under steady state. Besides, some main physical properties, such as reactivity control, neutron spectrum and flux, power density distribution, and reactivity coefficient,have been calculated and analyzed in this study. In addition, some special problems in molten salt coolant are also considered, including ~6Li depletion and tritium production. | Rui Yan Shi-He Yu Yang Zou Qun Yang Bo Zhou Pu Yang Hong-Hua Peng Ya-Fen Liu Ye Dai Rui-Ming Ji Xu-Zhong Kang Xing-Wei Chen Ming-Hai Li Xiao-Han Yu | 2018 | Nuclear Science and Techniques2018，29，6： | 2 |
| 11 | Snapshot multi-dimensional computational imaging through a liquid crystal diffuser显示文摘Multi-dimensional optical imaging systems that simultaneously gather intensity,depth,polarimetric,and spectral information have numerous applications in medical sciences,robotics,and surveillance.Nevertheless,most current approaches require mechanical moving parts or multiple modulation processes and thus suffer from long acquisition time,high system complexity,or low sampling resolution.Here,a methodology to build snapshot multi-dimensional lensless imaging is proposed by combining planar-optics and computational technology,benefiting from sufficient flexibilities in optical engineering and robust information reconstructions.Specifically,a liquid crystal diffuser based on geometric phase modulation is designed to simultaneously encode the spatial,spectral,and polarization information of an object into a snapshot detected speckle pattern.At the same time,a post-processing algorithm acts as a special decoder to recover the hidden information in the speckle with the independent and unique point spread function related to the position,wavelength,and chirality.With the merits of snapshot acquisition,multi-dimensional perception ability,simple optical configuration,and compact device size,our approach can find broad potential applications in object recognition and classification. | YUNSONG LEI QI ZHANG YINGHUI GUO MINGBO PU FANG ZOU XIONG LI XIAOLIANG MA XIANGANG LUO | 2023 | Photonics Research2023，11，3： | 2 |
| 12 | Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis显示文摘Clinical manifestations of rheumatoid arthritis(RA)are diversified,and based on the manifestations,the patients with RA could be classified into different patterns under traditional Chinese medicine.These patterns decide the selection of herbal prescription,and thus they can help find a subset of rheumatoid arthritis patients for a type of therapy.In the present study,we combine genome-wide expression analysis with methods of systems biology to identify the functional gene networks for the sets of clinical symptoms that comprise the major information for pattern classification.Clinical manifestations in rheumatoid arthritis were clustered with factor analysis,and two factors(similar to cold and hot patterns in traditional Chinese medicine)were found.Microarray technology was used to reveal gene expression profiles in CD4^(+)T cells from 21 rheumatoid arthritis patients.Protein-protein interaction information for these genes from databases and literature data was searched.The highly-connected regions were detected to infer significant complexes or pathways in this protein-protein interaction network.The significant pathways and function were extracted from these subnetworks using the Biological Network Gene Ontology tool.The genes significantly related to hot and cold patterns were identified by correlations analysis.MAPK signalling pathway,Wnt signaling pathway,and insulin signaling pathway were found to be related to hot pattern.Purine metabolism was related to both hot and cold patterns.Alanine,aspartate,and tyrosine metabolism were related to cold pattern,and histindine metabolism and lysine degradation were related to hot pattern.The results suggest that cold and hot patterns in traditional Chinese medicine were related to different pathways,and the network analysis might be used for identifying the pattern classification in other diseases. | Miao Jiang Cheng Xiao Gao Chen Cheng Lu Qinglin Zha Xiaoping Yan Weiping Kong Shijie Xu Dahong Ju Pu Xu Youwen Zou Aiping Lu | 2011 | Frontiers of Medicine2011，5，2： | 2 |
| 13 | AKT1 and AKT2 Promote Malignant Transformation in Human Brain Glioma LN229 Cells显示文摘 | Jian ZOU Kun WANG Lei HAN An-ling ZHANG Zhen-dong SHI Pei-yu PU Chun-sheng KANG | 2011 | Clinical oncology and cancer resexreh2011，8，3： | 2 |
| 14 | Wavelet time-frequency analysis of torsional vibrations in rotor system with a transverse crack显示文摘 | Zou J Chen J Pu Y P | 2004 | Computers and Structures2004，82，15： | 1 |
| 15 | Wavelet time-frequency analysis of torsional vibrations in rotor system with a transverse crack显示文摘 | Zou J Chen J Pu Y P | 2004 | Computers and Structures2004，82，： | 1 |
| 16 | Functional conservation and divergence of duplicated insulin-like growth factor 2 genes in grass carp ( Ctenopharyngodon idellus )显示文摘 | Xiang-Nan Yuan Xia-Yun Jiang Jian-Wei Pu Zhen-Rui Li Shu-Ming Zou | 2010 | Gene2010，，1： | 1 |
| 17 | On the wavelet timefrequency analysis algorithm in identification of a cracked rotor 显示文摘 | Zou J Chen J Pu Y P | 2002 | Journal of Strain Analysis for Engineering Design2002，37，3： | 1 |
| 18 | Highlights and perspectives of soil biology and ecology research in China显示文摘 | Pu S L Zou X M Coleman D | 2009 | Soil Biology and Biochemistry2009，41，5： | 1 |
| 19 | Effect of Microstructure on Tensile Properties of TiAl Based Alloy显示文摘EffectofMicrostructureonTensilePropertiesofTiAlBasedAlloyPuZhongjie;ShiJiandong;ZouDunxu;ZhongZengyongAbstract:Themicrostruct... | Pu Zhongjie Shi Jiandong Zou Dunxu Zhong Zengyong | 1996 | Journal of Iron and Steel Research(International)1996，3，1： | 1 |
| 20 | Thermodynamic Properties of Rashba Spin-orbit-coupled Fermi Gas显示文摘 | Zhen Zheng Han Pu Zou Xubo | 2014 | Phys Rev A2014，90，06： | 1 |
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