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| 1 | Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B显示文摘AIM:To investigate the relationships between polymorphisms of interleukin-lB (IL-1B) promoter region -511CLT and interleukin-1 receptor antagonist gene (IL-1RN) and susceptibility to chronic hepatitis B in Chinese population. METHODS: Genomic DNA was extracted from the peripheral blood of 190 patients with chronic hepatitis B and 249 normal controls and then subjected to polymerase chain reaction (PCR) amplification. The PCR products were digested by restriction endonuclease AvaI. The products of digestion were subjected to 20 g/L gel electrophoresis and ethidium bromide staining. RESULTS: The frequencies of IL-1B (-511) genotypes CC, CT and TT in patients with chronic hepatitis B were 23.7%, 49.5% and 26.8%, while 26.1%, 47.4% and 26.5% respectively in controls. The results showed that there was no significant difference in the frequencies of alleles or genotypes in IL-1B between patients with chronic hepatitis B and controls. The distributions of IL-1B (-511) genotype CC were significantly different between the two subgroups (HBV-DNA ≤1×10^3 copies/mL as subgroup I, HBV-DNA> 1×10^3 copies/mL as subgroup Ⅱ) of chronic hepatitis B (P=0.029). Only four of the five kinds of polymorphism (1/1, 1/2, 2/2 and 1/4) were found in this study. The frequencies of IL-1RN genotypes 1/1, 1/2, 2/2 and 1/4 were 88.9%, 9.0%, 0.5% and 1.6% in patients with chronic hepatitis B respectively, while were 81.1%, 16.9%, 0.4% and 1.6% respectively in controls. The frequencies of genotype1/2 and IL-1RN allele 2 in patients with chronic hepatitis B were lower than those in controls (P=0.016 and P=0.029, respectively). CONCLUSION: There is an association between polyrnorphisms of the promoter region -511C/T of IL-1B and IL-1RN intron 2 and chronic hepatitis B virus infection. SubJects with IL-1RN 2 may be resistant to HBV infection, and IL-1B(-511) geNotype CC is closely related with HBV-DNA replication, which gives some new clues to the study of pathogenesis of chronic hepatitis B. | Ping-AnZhang YanLi PuXu Jian-MinWu | 2004 | World Journal of Gastroenterology2004，10，12： | 13 |
| 2 | Shaping of metal-organic frameworks through a calcium alginate method towards ethylene/ethane separation显示文摘The separation of ethylene and ethane is a crucial,challenging and cost-intensive process in chemical engineering.Metal-organic frameworks(MOFs)are a class of novel porous adsorbents used for the separation of ethylene/ethane mixtures.However,MOFs are normally crystalline powders that cause multiple problems,such as dust,abrasion and heat/mass loss,as well as significant pressure drops on the adsorption bed resulting in a sudden stop in production.To solve these issues,we have prepared four different sphere-shaped adsorbents,including Mg-gallate,Co-gallate,MUV-10(Mn)and MIL-53(Al)using a calcium alginate method to achieve excellent ethylene/ethane separation performance.The performance of the sphere-shaped adsorbents has been validated using mechanical strength measurements,powder X-ray diffraction,scanning electron microscopy,thermogravimetric analysis,gas adsorption isotherms and dynamic breakthrough experiments.The excellent mechanical strength of these sphere-shaped adsorbents meets the criteria for industrial application in gas separation.Thus,the energy consumption and operating cost will be further reduced in the ethylene production process.We believe that this shaping method will open a prosperous route to the development of MOFs toward higher technology levels and their commercial application. | Jinlong Li Xiaoqing Wang Puxu Liu Xiaohua Liu Libo Li Jinping Li | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 2 |
| 3 | Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing显示文摘Complete skin reconstruction is a hierarchical,physiological assembly process involving healing of the epidermis,dermis,vasculature,nerves,and cutaneous appendages.To date,few works have reported complete skin regeneration,particularly lacking vascular structures and hair follicles after full skin defects.In this study,a hydrogel derived from the skin secretion of Andrias davidianus(SSAD)that features adhesiveness was used as a bioactive scaffold to load micronized amnion(MA).The SSAD hydrogel was found to promote the migration and proliferation of amnion stem cells and human keratinocytes,as well as inhibit their apoptosis in vitro.In a rat full-skin defect model,the regeneration of skin appendages was observed at the wound area,achieving scarless healing.Transcriptome analyses further validated that SSAD could positively regulate cell migration,proliferation,and differentiation.These functions might be attributed to the abundant growth factors present in the SSAD.Synergized by the delivery of MA,SSAD loaded with the MA could achieve a significantly better skin regeneration effect than SSAD or MA used alone,providing a simple yet highly effective means to obtain complete,scarless skin regeneration,suggesting favorable potential for clinical translation. | Huicong Zhang Mingyu Song Changhong Hu Zhiyi Zhang Shuqi Zhang Yan Zhang Yingming Yang Puxu Zhou Liwen Zheng Lan Li Mengjie Mao Yu Shrike Zhang Ping Ji Ximu Zhang | 2023 | Aggregate2023，4，5： | 0 |
| 4 | Stable titanium metal-organic framework with strong binding affinity for ethaneremoval显示文摘Direct separation of high purity ethylene(C_(2)H_(4))from an ethane(C_(2)H_(6))/ethylene mixture is a critical and challenging task owing to the very similar molecular size and physical properties of the two components.While some studies have attempted this separation,there is a lack of excellent porous materials with strong binding affinity for C_(2)H_(6)-selective adsorption via an energy-efficient adsorptive separation process.Herein,we report a titanium metal-organic framework with strong binding affinity and excellent stability for the highly efficient removal of C_(2)H_(6) from C_(2)H_(6)/C_(2)H_(4) mixtures.Single component adsorption isotherms demonstrated a larger amount of adsorbed ethane(1.16 mmol·g^(-1) under 1 kPa)and high C_(2)H_(6)/C_(2)H_(4) selectivity(2.7)for equimolar C_(2)H_(6)/C_(2)H_(4) mixtures,especially in the low-pressure range,which is further confirmed by the results of grand canonical Monte Carlo simulations for C_(2)H_(6) adsorption in this framework.The experimental breakthrough curves showed that C_(2)H_(4) with a high purity was collected directly from both 1:9 and 1:15 C_(2)H_(6)/C_(2)H_(4)(volume ratio)mixtures at 298 K and 100 kPa.Moreover,the unchanged adsorption and separation performance after cycling experiments confirmed the promising applicability of this material in future. | Puxu Liu Yong Wang Yang Chen Xiaoqing Wang Jiangfeng Yang Libo Li Jinping Li | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 0 |
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