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11篇 您的检索式：作者名="Puche E"

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		题名	作者	年代	出处	被引量
	1	Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis.	Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar	2008	World Journal of Gastroenterology2008，14，17：	11
	2	TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs显示文摘	Bounaix Morand du Puch C Barbier E Kraut A	2011	Arch Biochem Biophys2011，507，2：	1
	3	Review Diagnosis Methods of Induction Electrical Machines based on Steady State Current显示文摘	Rub(e)n Puche Panadero Joan Pons Llinares Vicente Climente Alarcon y Manuel Pineda S(a)nchez	2009	l lth Spanish Portuguese Conference On Electrical Engineering2009，，：	1
	4	Serum aspirin-esterase activity in epileptic patients receiving treatment with Phenobarbital,phenytoin,carbamazepine and valproic acid显示文摘	Puche E Garcia de la Serrana H Mota C		0，，01：	1
	5	Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1显示文摘	Munoz U Puche J E Hannivoort R		0，，09：	1
	6	High temperature wear resistance of (TiAl) N PVD eoating on untreated and gas nitrided AISI H13 steel with different heat treatments显示文摘	RODRIGUEZ - BARACALDO R BENITO J A PUCH! CA BRERA E S	2007	Wear2007，262，3：	1
	7	Treatment of biliary injuries after laparoseopic eholeeystectomy: retrospective study of 27 pa- tients显示文摘	Puche P Jacquet E Borie F	2007	J Chir2007，144，5：	1
	8	TwoGABAergic intraglomerular circuits differentially regulatetonic and phasic presynaptic inhibition of olfactory nerve ter-minals 显示文摘	SHAO Z PUCHE A C KIYOKAGE E	2009	J Neurophysiol2009，101，4：	1
	9	Evaluation of in- guinal hernia in ambulatory surgery: A prospective mono- centric study on 1009 inguinal hernia 显示文摘	Jacquet E Puche P Alahyane J	2006	Ambul Surg2006，12，4：	1
	10	Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid显示文摘	Puche E Garcia de la Serrana H	1989	Int J Clin Pharmacol Res1989，9，1：	1
	11	Cirrhosis:candidates for liver transplantation显示文摘	Jacquet E Puche P Jaber S	2005	Rev Prat2005，55，14：	1

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