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| 1 | Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress显示文摘The myocardium adapts to ischemic insults in a variety of ways.One adaptation is the phenomenon of acute preconditioning,which can greatly ameliorate ischemic damage.However,this effect wanes within a few hours and does not confer chronic protection.A more chronic adaptation is the so-called second window of preconditioning,which enables protection for a few days.The most potent adaptation invoked by the myocardium to minimize the effects of ischemia is the growth of blood vessels in the heart,angiogenesis and arteriogenesis (collateral growth),which prevent the development of ischemia by enabling flow to a jeopardized region of the heart.This brief review examines the mechanisms underlying angiogenesis and arteriogenesis in the heart.The concept of a redox window,which is an optimal redox state for vascular growth,is discussed along with signaling mechanisms invoked by reactive oxygen species that are stimulated during ischemia-reperfusion.Finally,the review discusses of some of the pathologies,especially the metabolic syndrome,that negatively affect collateral growth through the corruption of redox signaling processes. | Yuh Fen Pung William M Chilian | 2010 | World Journal of Cardiology2010，2，12： | 5 |
| 2 | Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children显示文摘AIM To describe our institutional experience with conversion from intravenous(IV) fentanyl infusion directly to enteral methadone and occurrence of withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation and analgesia.METHODS With Institutional Review Board approval,we retrospectively studied consecutively admitted invasively mechanically ventilated children(0-18 years) sedated with IV fentanyl infusion > 5 d and subsequently converted directly to enteral methadone.Data were obtained onsubject demographics,illness severity,daily IV fentanyl and enteral methadone dosing,time to complete conversion,withdrawal scores(WAT-1),pain scores,and need for rescue opioids.Patients were classified as rapid conversion group(RCG) if completely converted ≤ 48 h and slow conversion group(SCG) if completely converted in > 48 h.Primary outcome was difference in WAT-1 scores at 7 d.Secondary outcomes included differences in overall pain scores,and differences in daily rescue opioids.RESULTS Compared to SCG(n = 21),RCG(n = 21) had lower median WAT-1 scores at 7 d(2.5 vs 5,P = 0.027).Additionally,RCG had lower overall median pain scores(3 vs 6,P = 0.007),and required less median daily rescue opioids(3 vs 12,P = 0.003) than SCG.The starting daily median methadone dose was 2.3 times the daily median fentanyl dose in the RCG,compared to 1.1 times in the SCG(P = 0.049).CONCLUSION We observed wide variation in conversion from IV fentanyl infusion directly to enteral methadone and variability in withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation.In those children who converted successfully from IV fentanyl infusion to enteral methadone within a period of 48 h,a methadone:fentanyl dose conversion ratio of approximately 2.5:1 was associated with less withdrawal and reduced need for rescue opioids. | Vijay Srinivasan Daniel Pung Sean P O'Neill | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 3 | In vitro cultivation of Microphallus turgidus ( Trematoda : microphalldae) from metacercaria to ovigerousadult with continuation of the life cycle in the laboratory 显示文摘 | Pung OJ Burger AR Walker MF | 2009 | J Parasitol2009，95，4： | 1 |
| 4 | Toxic Effects of leaf and flower crude extracts from Lantana camara on Tetranychus urticae显示文摘 | SRIMONGKOLCHAI W VICHITBANDHA P PUNG T | 2013 | Asian Journal of Chemistry2013，25，9： | 1 |
| 5 | Induction of detoxi- fying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals 显示文摘 | CHEN C PUNG D LEONG V | 2004 | Free Radical Biology and Medicine2004，37，10： | 1 |
| 6 | Toward an OSGi-based infrastructure for context-aware applications显示文摘 | Gu T Pung H K Zhang D Q | 2004 | IEEE Pervasive Computing2004，3，4： | 1 |
| 7 | Diverse carotenoids protect against chemically induced neoplastic transformation显示文摘 | Bertram J S Pung A Churley M | 1991 | Carcinogenesis1991，12，： | 1 |
| 8 | A Service-Oriented Middleware for Building Context-Aware Services显示文摘 | Gu T Pung H K Zhang D Q | 2005 | Journal of Network and Computer Applications2005，，28： | 1 |
| 9 | A Service-oriented Middleware for Building Context-ware Services显示文摘 | Gu Tao Pung Hung-Keng Zhang Daqing | | 0，，01： | 1 |
| 10 | Frequent high telomerase reverse transcriptase expression in primary oral squamous cell earcinoma显示文摘 | FrderK Pungs S Flechtenmacher C | 2007 | J Oral Pathol Med2007，36，5： | 1 |
| 11 | A service-orien ted middleware for building context-aware services 显示文摘 | TAO Gu Hung Keng Pung ZHANG Daqing | 2005 | Journal of Network and Computer Applications2005，28，1： | 1 |
| 12 | A timed workflow process model 显示文摘 | Zhuge Hai Cheung To-yat Pung Huang-keng | 2001 | The Journal of Systems and Software2001，55，3： | 1 |
| 13 | Diverse carotenoid protect from chemecally induced neoplacia transformetion显示文摘 | Bertram J S Pung A | 1991 | Carcinogenesis1991，12，： | 1 |
| 14 | A context realization frame- work for ubiquitous applications with runtime support 显示文摘 | ZHU J PUNG H K OLIYA M | 2011 | IEEE Communication Magazine2011，49，9： | 1 |
| 15 | β-carotene and canthaxanthin inhibit chemically and physically induced neoplastic transformation in 10T1/2 cells 显示文摘 | Pung A | 1988 | Carcinogenesis1988，9，： | 1 |
| 16 | Diverse carotenoid Protect from chemically induced neoplacia transformation显示文摘 | Bertram J S Pung A | 1996 | Carcinogenesis1996，12，： | 1 |
| 17 | High survivin expression is associated with favorable outcome in advanced primary oral squamous cell carcinoma after radiation therapy显示文摘 | Freier K Pungs S Sticht C | 2007 | Int J Cancer2007，120，4： | 1 |
| 18 | HERC5 is an IFN-indueed HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets 显示文摘 | Wong JJ Pung YF Sze NS | 2006 | Proc Natl Acad Sci U S A2006，103，10： | 1 |
| 19 | Measuring the economic impact of the British Library 显示文摘 | Pung C | 2004 | New Review of Academic Librari- anship2004，10，1： | 1 |
| 20 | A timed workflow process mode 显示文摘 | To-yat Cheung Hung-keng Pung | 2001 | The Journal of Systems and Software2001，55，： | 1 |
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