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| 1 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 2 | Hot pepper ( Capsicum annuum , Tepin and Capsicum chinese , Habanero) prevents Fe 2+ -induced lipid peroxidation in brain – in vitro显示文摘 | G. Oboh R.L. Puntel J.B.T. Rocha | 2006 | Food Chemistry2006，，1： | 3 |
| 3 | Enhanced characterization of solid solitary pulmonary nodules with Bayesian analysis-based computer-aided diagnosis显示文摘The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomography(CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator(BIMC) model predictions. Raters' predictions were evaluated by means of receiver operating characteristic(ROC) curve analysis and decision analysis. Overall ROC area under the curve was 0.758 before and 0.803 after the disclosure of CAD predictions(P = 0.003). A net gain in diagnostic accuracy was found in 6 out of 7 readers. Mean risk class of benign nodules dropped from 2.48 to 2.29, while mean risk class of malignancies rose from 3.66 to 3.92. Awareness of CAD predictions also determined a significant drop on mean indeterminate SPNs(15 vs 23.86 SPNs) and raised the mean number of correct and confident diagnoses(mean 39.57 vs 25.71 SPNs). This study provides evidence supporting the integration of the Bayesian analysis-based BIMC model in SPN characterization. | Simone Perandini Gian Alberto Soardi Massimiliano Motton Raffaele Augelli Chiara Dallaserra Gino Puntel Arianna Rossi Giuseppe Sala Manuel Signorini Laura Spezia Federico Zamboni Stefania Montemezzi | 2016 | World Journal of Radiology2016，8，8： | 3 |
| 4 | Krebs Cycle Intermediates Modulate Thiobarbituric Acid Reactive Species (TBARS) Production in Rat Brain In Vitro显示文摘 | Robson L. Puntel Cristina W. Nogueira Jo?o B. T. Rocha | 2005 | Neurochemical Research2005，，2： | 2 |
| 5 | A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics显示文摘 | Puntel M Muhammad KMG Candolfi M | | 0，，： | 1 |
| 6 | Safety profile, effiea cy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxie gene therapy as a prelude to a phase I clinical trial for glioblasto ma显示文摘 | Puntel M Farrokhi C Vanderveen N | 2013 | Toxicol Al:Jpl Pharmacol2013，268，3： | 1 |
| 7 | Serologic survey of viral antibodies in llamas (Lama glama) in Argentina 显示文摘 | Puntel M Fondvila N A Blanco V J | 1999 | Zentrabl veterinarmed B1999，46，3： | 1 |
| 8 | Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: Involvement of oxidative stress and glutamatergic systerm 显示文摘 | Roos DH Puntel RL Santos MM | 2009 | Toxicol in Vitro2009，23，： | 1 |
| 9 | Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector en- coding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma 显示文摘 | Puntel M AKM GM Farrokhi C | 2013 | Toxicol Appl Pharmacol2013，268，3： | 1 |
| 10 | Mitochondrial electron transfer chain complexes inhibition by different organochalcogens显示文摘 | Puntel R L Roos D H Seeger R L | | 0，，1： | 1 |
| 11 | Manganese in health and disease显示文摘 | Avila DS Puntel RL Aschner M | 2013 | Met Ions Life Sci2013，13，7： | 1 |
| 12 | Regulatable gene expression systems for gene therapy applications:progress and future challenges显示文摘 | Goverdhana S Puntel M Xiong W | 2005 | Mol Ther2005，12，2： | 1 |
| 13 | Regulatable gene expression systems for gene therapy applications: progress and future challenges显示文摘 | Goverdhana S Puntel M Xiong W | 2005 | Mol Ther2005，12，2： | 1 |
| 14 | Oxalate modulates thiobarbituric acid reactive species (TBARS) production in su- pernatants of bomogenates from rat brain, liver and kidney~ Effect of diphenyl diselenide and diphenyl ditelluride显示文摘 | Puntel R L Roos D H Paixao M W etal | 2007 | Chem Biol Interact2007，165，2： | 1 |
| 15 | Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges显示文摘 | Goverdhana S Puntel M Xiong W | 2005 | Mol Ther2005，12，2： | 1 |
| 16 | Oxalate modulates thiobarbituric acid reactive species (TBARS) production in su- pematants of homogenates from rat brain, liver and kidney: Effect of diphenyl diselenide and diphenyl ditelluride 显示文摘 | Puntel RL Roos DH Paixao MW | 2007 | Chem Biol Interact2007，165，2： | 1 |
| 17 | Regulatable gene expression systems for gene therapy applications:progress and future challenges显示文摘 | GOVERDHANA S PUNTEL M XIONG W | 2005 | Mol Ther2005，12，2： | 1 |
| 18 | Fracture mechanics based model for joints under cyclic loading显示文摘 | PUNTEL E BOLZON G SAOUMA V E | 2006 | Journal of Engineering Mechanics2006，132，11： | 1 |
| 19 | Fracture Mechanics Based Model for Joints under Cyclic Loading 显示文摘 | PUNTEL E BOLZON G SAOUMA V E | 2006 | Journal of Engineering Mechanics2006，132，11： | 1 |
| 20 | Hot pepper ( Capsicum annuum , Tepin and Capsicum chinese , Habanero) prevents Fe 2+ -induced lipid peroxidation in brain – in vitro显示文摘 | G. Oboh R.L. Puntel J.B.T. Rocha | 2006 | Food Chemistry2006，，1： | 1 |
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