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| 1 | 区域地震滑坡体积优化模型显示文摘求取滑坡体积在当前是一个难题,原因是其为三维分量,并且部分滑面往往在地下。本文提出了3个区域地震滑坡体积优化模型来计算2008年中国汶川M W7.9地震触发滑坡的体积。本文首先基于20m分辨率的震前和震后SPOT 5卫星影像提取到的数字高程模型(DEM)数据,结合少数滑坡的剖面图,获得了1 415处汶川地震滑坡堆积区体积,作为地震滑坡体积模型训练样本。在常规区域滑坡'体积—面积'模型基础上,提出了3个优化模型。分别利用数据的对数化线性拟合与直接非线性拟合方法对1个常规模型和3个优化模型进行拟合。结果表明,采用直接非线性拟合方法并考虑了滑坡长、宽、高、岩性、坡度和峰值地动加速度后,坡向的优化模型标准误差最小,回归得到的滑坡总体积与滑坡真实总体积也非常接近。将这一模型应用于所有汶川地震滑坡,分别得到每个滑坡的体积。最终结果表明,汶川地震滑坡相对密集分布区内的196 007处滑坡的堆积物体积约为1.2×1010 m^3,源区体积约为1×1010 m^3。根据前人'地震震级—滑坡总体积'经验公式得到的结果仅仅是本文结果的7.5%~9%,这提醒我们有必要基于更多的单次地震触发滑坡总体体积数据对'地震震级—滑坡总体积'的关系进行更新。同时,文中的优化模型对同类研究也有显著的参考价值。 | C.Xu X.W.Xu L.L.Shen Q.Yao X.B.Tan W.J.Kang S.Y.Ma X.Y.Wu J.T.Cai M.X.Gao K.Li 许冲(译) 吕春来(校) | 2018 | 世界地震译丛2018，49，3： | 2 |
| 2 | A targeted covalent inhibitor of p97 with proteome-wide selectivity显示文摘A resurging interest in targeted covalent inhibitors(TCIs)focus on compounds capable of irreversibly reacting with nucleophilic amino acids in a druggable target.p97 is an emerging protein target for cancer therapy,viral infections and neurodegenerative diseases.Extensive efforts were devoted to the development of p97 inhibitors.The most promising inhibitor of p97 was in phase 1 clinical trials,but failed due to the off-target-induced toxicity,suggesting the selective inhibitors of p97 are highly needed.We report herein a new type of TCIs(i.e.,FL-18)that showed proteome-wide selectivity towards p97.Equipped with a Michael acceptor and a basic imidazole,FL-18 showed potent inhibition towards U87 MG tumor cells,and in proteome-wide profiling,selectively modified endogenous p97 as confirmed by in situ fluorescence scanning,label-free quantitative proteomics and functional validations.FL-18 selectively modified cysteine residues located within the D2 ATP site of p97.This covalent labeling of cysteine residue in p97 was verified by LC-MS/MS-based site-mapping and site-directed mutagenesis.Further structure-activity relationship(SAR)studies with FL-18 analogs were established.Collectively,FL-18 is the first known small-molecule TCI capable of covalent engagement of p97 with proteome-wide selectivity,thus providing a promising scaffold for cancer therapy. | Zi Ye Ke Wang Lianguo Chen Xiaofeng Jin Hao Chen Guanghui Tang Shao Q.Yao Zhiqiang Feng Chong-Jing Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 3 | PD‐1 negatively regulates interleukin‐12 expression by limiting STAT‐1 phosphorylation in monocytes/macrophages duringchronic hepatitis C virus infection显示文摘 | Cheng J.Ma LeiNi YingZhang C.L.Zhang Xiao Y.Wu Antwan N.Atia PennyThayer Jonathan P.Moorman Zhi Q.Yao | 2011 | Immunology2011，，3： | 1 |
| 4 | Feeding‐based RNA interference of a trehalose phosphate synthase gene in the brown planthopper, Nilaparvata lugens显示文摘 | J.Chen D.Zhang Q.Yao J.Zhang X.Dong H.Tian J.Chen W.Zhang | 2010 | Insect Molecular Biology2010，，6： | 1 |
| 5 | A reversible microarray immobilization strategy based on thiol-quinone reaction显示文摘Microarray technology has been widely applied in biomedical research.The key to microarray study is to develop efficient immobilization method.In this study,we designed a new reversible microarray immobilization method based on thiol-quinone reaction.A quinone-functionalized slide was fabricated through H_(2)O_(2)treatment of dopamine-coated slides.Various thiol-containing molecules can be anchored onto the quinone-functionalized slides via thioether linker,which could be cleaved under H_(2)O_(2) treatment to regenerate quinone groups on the surface.The highly versatile approach can be widely used for immobilization of various thiol-containing molecules. | Ling Feng Ping Wang Yi Feng Jie Zhang Qingxin Chen Yusheng Xie Jingdong Luo Jiang Xia Shao Q.Yao Hongyan Sun | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 6 | Preface for the special issue on analysis of drug or drug targets by molecular imaging显示文摘To increase the chance of a successful outcome in clinic and in the development of innovative drugs,researchers aim to provide more compre hensive information about the disease and drugs to adapt treatment decisions according to an individual disease's mo-lecular characteristics.It is thus increasingly desirable to illuminate fund amental molecular pathways of the drug and its targets inside organisms in a non-invasive manner.Technologies developed in molecular imaging assist in visualizing,characterizing,and quanti-fying targets of interest at the molecular level within intact living organisms.This special issue of Joumal of Pharmaceutical Analysis is therefore dedicated to highlighting current progresses made in molecular imaging towards various drugs,important or promising drug targets,and their interactions,as well as to providing a forum for sharing new methods reported recently for the efficient phar-maceutical analysis. | Linghui Qian Shao Q.Yao | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 0 |
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