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| 1 | Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle. | WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | Science China Earth Sciences2014，57，12： | 21 |
| 2 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 3 | Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing显示文摘 | Wei Qin Fang Liang Yan Feng Haipeng Bai Ruibin Yan Song Li Shuo Lin | 2015 | Cell Research2015，25，9： | 6 |
| 4 | Detection of the critical micelle concentration of cationic and anionic surfactants based on aggregation-induced emission property of hexaphenylsilole derivatives显示文摘We report a fluorescence 'turn-on' method to detect the critical micelle concentration (CMC) of surfactants. This method works well for both cationic and anionic surfactants. It employs an unprecedented mechanism (aggregation-induced emission, or AIE) to determine the CMC values, and the results are consistent with the data obtained by the classical techniques. In addition, this method renders the convenient detection of the CMC values. Any large and professional instruments are unnecessary, instead, a portable UV lamp and an ultrasonic generator are enough to carry out the detection in an ordinary laboratory. Considering that micelles are interesting entities and have found applications in many important fields such as emulsion polymerization, template of nanosized materials synthesis, controllable drug delivery and macromolecular self-assembling. Our experimental results may offer a facile, sensitive and promising method to detect the formation of micelles constructed by the new amphiphilic molecules and macromolecules. | TANG Li JIN JiaKe ZHANG Shuang MAO Yu SUN JingZhi YUAN WangZhang ZHAO Hui XU HaiPeng QIN AnJun TANG Ben Zhong | 2009 | Science China Chemistry2009，52，6： | 6 |
| 5 | Low Cost and Reusability of Launch Vehicle显示文摘This paper analyzes the launch price of the launch vehicles, domestic and abroad, studies the status and trend of the low cost launch vehicles, and introduces two measures to reduce the cost by means of evolved and disruptive technologies, utilizing the concept of low cost manufacturing and operating modes as well. This paper also analyzes the launch strategies for small satellites such as piggyback, networking launch, and single launch with a small launch vehicle(SLV). Finally, the development trend of reusable launch vehicles is discussed as well as the development prospects for China's reusable launch vehicle. | LU Yu QIN Xudong CHEN Haipeng | 2016 | Aerospace China2016，17，2： | 2 |
| 6 | Zircon U-Pb age, Lu-Hf Isotopic Characteristics and Origin of the Banshanping Granitoid Rocks in East Qinling Orogenic Belt显示文摘The Banshanping granitoid rocks distribute in the east of the North Qinling orogenic belt. It is a diorite-quartz diorite-granodiorite-granite series, spreading in a NW-SE direction, and intrudes into the Erlangping Group. The SiO2 content ranges from 57.04% to 76.56%, Na2O from 2.05% to 4.65%, K2O from 0.84% to 3.40%. Major element characteristics indicate that Banshanping granitoid rocks have properties of I type granotoids. SREE ranges from 36.51 ppm to 473.25 ppm, and LREE/HREE ratios lie between 3.95 and 22.18. Negative Eu anomalies are not obvious in most samples, though there are obvious Nb, P and Ti positive anomalies. The zircon LA-ICP-MS ages of Banshangping granitoid rocks are 496.0±8.1 Ma–486.9±9.3 Ma. Hf isotope shows that 176Hf/177Hf ratios range from 0.282721 to 0.282876, εHf(t) values from 8.5 to 14, all positive, and corresponding modal ages(TDM2) range from 559 Ma to 908 Ma. Based on Hf isotope characteristics and existing SmNd and Rb-Sr isotope data, we consider that the Banshanping granitoid rocks originate from mantlederived material, i.e. the igneous rocks that formed in Neoproterozoic, and there may be a certain amount of crust-derived material during the formation of Banshanping granitoid rocks. | LI Mingze WU Cailai LEI Min QIN Haipeng LIU Chunhua | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 2 |
| 7 | Soft ionic-hydrogel electrodes for electroencephalography signal recording显示文摘Wet gel electrodes have been widely used for electroencephalography(EEG) signal recording, which generally causes skin abrasion and longer preparation time. In this paper, we present soft ionic-hydrogel based electrodes to overcome such drawbacks.In order to conveniently measure the EEG signals, we design the claw-like and patch-like structures for robust connection between metal(Ag/Ag Cl) electrodes and skin scalps. Next, we experimentally show that the soft ionic-hydrogel based electrodes have similar performance with the conventional wet gel electrodes in terms of the short-circuit noise, electrical impedance, and skin-electrode contact impedance on unprepared human skin, significantly better than dry electrodes and water-based electrodes.We further perform the EEG measurements and steady-state visual evoked potentials(SSVEP) experiments with five subjects to verify the effectiveness of the soft ionic-hydrogel based electrodes. The experimental results demonstrate that our developed soft ionic-hydrogel electrodes can record high-quality EEG signals in a fast and clean way, being a compelling option for EEG-based brain-computer interfaces. | SHENG XinJun QIN Zhun XU HaiPeng SHU XiaoKang GU GuoYing ZHU XiangYang | 2021 | Science China(Technological Sciences)2021，64，2： | 1 |
| 8 | Adaptability of pullets from cages to a large cage aviary unit system during the initial settling-in period显示文摘Pullets often raised in cage system from week 1 to week 13 in China,when transferred to aviary system after,there will be a problem with adapt.A large cage aviary unit(LCAU)system was developed,which allocated with facilities such as ramps to help cage reared hens to adapt to the multi-tier space.To investigate hens’adaptability to the new system,space use over time in the LCAU system during the first 10 days after hens transferred were recorded,instantaneous scan sampling and continuous focal sampling were used to assess the behavior difference of hens between the LCAU and conventional cage(CC)systems.On the first day of arrival,10.03% of hens reached the second tier(S2)and the third tier(S3)of the aviary.During the observation period,an average of 2.42% of hens climbed and stayed at the upper tiers every day.Space allowance on floor of the first tier(S1)increased from 444.62 cm^(2)/hen(91 d)to 586.32 cm^(2)/hen(100 d),which was more than 540 cm^(2)/hen in the CC system.Comfort behaviors in the LCAU system were significantly more than in the CC system(p<0.01)and hens performed more comfort behaviors with the increase of days after transferred.Hens ate and drank less in the LCAU system in the beginning,however,with the increasing use of upper space,hens ate and drank more and more in the LCAU system during the 10 days after transferred from CC system.Consequently,there were no difference of feed behavior between the CC and LCAU systems(p>0.05)on the last 5 days of the whole observing period.The results indicated that hens gradually learned to use the 3-dimensional space in the initial settling-in period and,gained a good welfare condition in LCAU system.Further studies are needed to investigate the three-dimensional preferences and behavior expression in difference period to bridge the gap in knowledge of space use capacity among adult laying hens. | Liu Yang Qin Tong Haipeng Shi Gang Chen Zhengxiang Shi Weichao Zheng Baoming Li | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 0 |
| 9 | Simulated evolution process of core-shell microstructures显示文摘The evolution process of core-shell microstructures formed in monotectic alloys under the space environment condition was investigated by the numerical simula- tion method. In order to account for the effect of surface segregation on phase separation, Model H was modified by introducing a surface free energy term into the total free energy of alloy droplet. Three Fe-Cu alloys were taken as simulated examples, which usually exhibit metastable phase separation in undercooled and microgravity states. It was revealed by the dynamic simulation process that the formation of core-shell microstructures depends mainly on surface segregation and Marangoni convection. The phase separation of Fe65Cu35 alloy starts from a dispersed structure and gradually evolves into a triple-layer core-shell micro- structure. Similarly, Fe50Cu50 alloy experiences a structural evolution process of 'bicontinuous phase → quadruple-layer core-shell → triple-layer core-shell', while the microstructures of Fe35Cu65 alloy transfer from the dispersed structure into the final double-layer core-shell morphology. The Cu-rich phase always forms the outer layer because of surface segregation, whereas the internal microstructural evolu- tion is controlled mainly by the Marangoni convection resulting from the tempera- ture gradient. | QIN Tao WANG HaiPeng WEI BingBo | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，4： | 0 |
| 10 | Enhanced magneto-optical Kerr effect and index sensitivity in Au/Fe_xCo_(1-x) magnetoplasmonic transducers显示文摘Magnetoplasmonic sensors are attractive candidates for ultrasensitive chemical and biomedical sensor applications.A variety of ferromagnetic metal thin films have been used for magnetoplasmonic device applications, yet the dependence of sensor performance on the optical and magneto-optical properties of ferromagnetic metal materials has been rarely studied. In this work, we report the study of enhanced magneto-optical Kerr effect(MOKE) and sensing performance in Au∕Fe_xCo_(1-x)bilayer magneto-optical surface plasmon resonance(MOSPR) transducers.The optical constants of Fe_xCo_(1-x)(x = 0, 0.29, 0.47, 0.65, and 1) in a sputter-deposited Au∕Fe_xCo_(1-x)device are characterized by the attenuated total internal reflection(ATR) method. Fe_xCo_(1-x)thin films show different MOKEs as a function of the chemical concentration, with the highest transverse MOKE signal observed in Fe_0.7Co_0.3.Index sensing performance is closely related to the material's optical and magneto-optical constants. By studying the sensing performance in the parameter space of the Au∕Fe_xCo_(1-x)bilayer thicknesses, the highest sensitivity is found to be 0.385(theoretical) and 0.306 RIU^(-1)(experimental) in the Au∕Fe_0.7Co_0.3 MOSPR devices. Our research highlights the influence of the optical properties of ferromagnetic material to device sensitivity in MOSPR transducers. The high sensitivity in Au∕Fe_xCo_(1-x)MOSPR devices make these structures attractivecandidates for chemical and biomedical sensing applications. | HAIPENG LU CHUAN LIU JUN QIN CHUANGTANG WANG YAN ZHANG LONGJIANG DENG LEI BI | 2017 | Photonics Research2017，5，5： | 0 |
| 11 | Optimal Deployment Density for Maximum Coverage of Drone Small Cells显示文摘With the proliferation of small and mini drones, Drone Small Cells(DSCs) can cooperative multiple drones to provide communication service for ground users as emergency means or supplementary ones of traditional terrestrial cellular networks. In this paper, we study the fundamental problem of optimizing the deployment density of DSCs to achieve the maximum coverage performance. Most related works do not consider cumulative inter-cell interference when studying the coverage performance of DSCs. First, we derive an approximate and closed-form expression of the cumulative inter-cell interference which comes from both probabilistic Line-of-Sight(Lo S) and Non-Line-of-Sight(NLo S) links. Then, we analyze the coverage performance of DSCs and derive the transcendental function of optimal deployment density to obtain the maximum coverage. Last, we propose an algorithm to get the optimal deployment density with low complexity. We conduct both field experiments and Matlab simulations to verify the correctness of theoretical analysis. In addition, we show the impact of some factors on the relation between the deployment density and coverage performance through extensive numerical simulations. | Chao Dong Jiejie Xie Haipeng Dai Qihui Wu Zhen Qin Zhiyong Feng | 2018 | China Communications2018，15，5： | 0 |
| 12 | Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis显示文摘Dear Editor,Kras and p53 mutation are among the most common gene mutations in lung cancer,which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction,which has been implicated to promote the inflammation-to-cancer transition.2 We established a lung adenocarcinoma model by using conditional alleles of KrasLSLG12D/p53flox/flox in mice3 to evaluate the effect of Baicalein(5,6,7-trihydroxyflavone),a principal component of Scutellaria baicalensis in traditional Chinese medicine,4 on the initiation and progression of lung cancer.Cre-mediated expression of KrasG12D and deletion of p53 caused obvious tumor lesions in the lung,which were strongly inhibited by the administration of Baicalein(Fig.1a,b and Supplementary Fig.1a,b),indicating that Baicalein is highly potent in inhibiting the progression of primary lung cancer. | Tiansheng Zheng Haipeng Liu Yifan Hong Yajuan Cao Qing Xia Chengge Qin Ming Li Russel J.Reiter Yidong Bai Lihong Fan | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 13 | Origin and geological control of desorbed gas in multi-thin coal seam in the Wujiu depression, Hailar Basin, China显示文摘To understand the natural gas characteristics of multi-thin coal seam,this study selected the desorbed gas of coal seams in different layers of Well A in the Wujiu depression,Hailar Basin in northeast Inner Mongolia.The results show that the heavy hydrocarbon content of desorbed gas increases significantly with the increasing depth.Methane carbon(δ13C_(1))and ethane carbon(δ13C_(2))isotope values are vertically become heavier downwards,while the δ13 values did not change significantly.The kerogen is close to the III–II mixed type with the source rocks mainly deposited in a shore/shallow lake or braided-river delta front,and the gas produced has certain characteristics of oil associated gas.However,the characteristics of oil associated gas produced by the organic formed in the shallow-water environment(braided-river delta plain)are not obvious.The sandstone pore and fracture systems interbedded with multi-thin coal seam are well developed.And it is conducive to the migration of methanogenic micro-organisms to coal seams via groundwater,making it easier to produce biogenic gas under this geological condition.During the burial evolution of coal-bearing strata in the study area,when the burial depth reaches the maximum,there are significant differences in the paleotemperature experienced by different vertical coal seams,caused by a high-paleogeothermal gradient,increasing the δ13C_(2) of desorbed gas with increasing depth.The above research indicates that there is less biogenic gas in the multi-thin coal seams with relatively developed mudstone,and the multi-thin coal seams with relatively developed sandstones have obvious biogenic gas characteristics.Therefore,for the exploration and development of biogenic gas in low-rank multi-thin coal seams,it is necessary to give priority to the layer with high sandstone content. | Geng LI Yong QIN Xuejuan SONG Boyang WANG Haipeng YAO Yabing LIN | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
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