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| 1 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 2 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 3 | Effect of polysaccharide from Enteromorpha prolifera on maize seedlings under NaCl stress显示文摘In this study, a polysaccharide from Enteromorpha prolifera (EP) was extracted and its effect on maize seedlings under NaCl stress was investigated. Firstly, the components and structure of the EP were determined. We found that EP is a sulfated polysaccharide of high-molecular weight (Mw, 1 840 KDa) heteropolysaccharides and the main monosaccharide is rhamnose. The polysaccharide was applied to explore its effect on the growth of maize seedlings and its defense response under a salt stress. The results show that EP could promote the growth of maize seedlings under the salt stress. In addition, EP was shown able to significantly regulate membrane permeability and adjustment of osmotic substances such as soluble protein, soluble sugar, and proline, antioxidant enzymes containing superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase. Therefore, EP is an effective salt-resistant substance for the growth of maize seedlings under NaCl stress. | LIU Song LI Bing CHEN Xiaolin QIN Yukun LI Pengcheng | 2019 | Journal of Oceanology and Limnology2019，37，4： | 2 |
| 4 | Research on a MCOP algorithm for optimized path显示文摘 | Qin Yong Wang Yukun Zhao Chenggui | 2006 | Journal of Information & Computational Science2006，3，4： | 1 |
| 5 | Effects of additive boron on HPHT diamond single crystals grown by TGM显示文摘In this work, under pressure 5.4 GPa and temperature 1250-1400°C, large gem-diamond single crystals with perfect shape and different content of additive boron were synthesized using temperature gradient method. High-purity boron powders were added as boron source into the graphite powder, and the effects of additive boron on crystal growth habit were investigated in detail. The relationship between the growth rate and the amount of additive boron was studied. The scanning electron microscopy was employed to study the morphology of boron-doped diamond crystals. Raman spectroscopy and Hall measurements were used to investigate the crystal structures and the carrier concentration, respectively. The results show that with the increase of the content of boron added into graphite powder, the crystal growth rate and the carrier concentration increase firstly, and decrease afterwards, and the zone-center phonon line at 1332 cm 1 has small shift to lower energy. The defects occur on the crystal surface when excessive boron is added in the synthesis system. | XIAO HongYu QIN YuKun LI ShangSheng LIANG ZhongZhu MA HongAn JIA XiaPeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 1 |
| 6 | The Second-Order Imaginary Plane Method and Its Calculation Accuracy显示文摘In this paper, the basic principles and mathematical process of the Second-order Imaginary Plane Method (IPM) for modeling the radiative heat transfer are analysed and proved in detail. Through the numerical computation for the real process of the radiative heat transfer using the Second-order IPM,the previous IPM (the first-order), the Analytic Method and the Zone Method, it was shown that the calculation accuracy of the Secondr-order IPM is much higher than that of the first-order IPM, and its demand to computer capacity and time consuming is much lower than that of the Zone Method or the Analytic Method. It is verilied that the method is more effective and has a higher accuracy for modeling radiative heat transfer in engineering. | Dong Peng Chen Xiaodong Zhu Tong Qin Yukun(Dept. of Power Engineering, Haxbin Institute of Technology, Harbin, 150001, China) | 1997 | Journal of Thermal Science1997，6，2： | 1 |
| 7 | Numerical Study of the Effect of Imaginary Circle Diameter and Initial Flow Field on the Aerodynamic Field in a Tangentially Fired Furnace显示文摘In this paper, the effect of the imaginary circle diameter opi and the initial flow field on the aerodynamic field in a tangentially fired furnace was studied by numerical simulation and experiments in the cold model. Results show that merely reducing the imaginary circle diameter rki can not significantly reduce the rotatiollal diameter op in the range considered. The flow still rotates coullter-clockwise stably and does not change rotation direction when the direction of all jet axes are defiected suddenly to the opposite rotation direction by up to 5.4' in a countereclockwise llow field. It is the first time that the numerical sAnulation results were obtained which agreed quite well with this experimental phenomena qualitatively. The experimental data, i.e., the rotational diameter & and the maximum velocity on the syrnmetric central line of fUrnace Vm, are only a bit larger than the simulation results. It is shown that the initial flow field has an important influence on the aerodynamic field in the furnace. Other measures have to be taken as wel1 in order to reduce & to resist slagging and high temperature corrosion of furnace tubes. Moreover, a new kind of grid arrangement was proposed in this paper, which can reduce effectively the false diffosion at the exit zone of burner. | Zhu Tong Sun Shaozeng Xia Chunyi An Baizeng Wu Shaohua Qin Yukun(School of Energy Science and Engineering, Harbin Institute of Technology, 150001, Harbin, China)Ma Xichen(Haxbin Boiler Works) | 1997 | Journal of Thermal Science1997，6，2： | 1 |
| 8 | Preparation,characterization,and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives显示文摘Phytopathogenic fungi cause heavy negative impact on the agricultural economy,but most existing fungicides are toxic and pose a threat to both human health and environments.A green and efficient fungicide is urgently needed.Chitooligosaccharides(COSs),the degradation products of natural polysaccharide chitosan,are nontoxic and biodegradable antifungal substances.In this study,a novel type of aminourea chitooligosaccharide derivatives(AUCOS)was synthesized by successively grafting a hydrazine group and an amine-carbonyl group onto a chitooligosaccharide backbone to enhance the antifungal capability of COSs.The structures of the target compounds were identified by FTIR,1H NMR,and 13C NMR,and the degree of substitution of each product was calculated from the results of the elemental analysis.The antifungal activities of the prepared chitooligosaccharide derivatives against Fusarium solani,Verticillium albo-atrum and Phytophthora capsici were tested in vitro.The AUCOSs had better inhibitory efficiencies against the three plant pathogen fungi than that of chitooligosaccharide,of which aminourea chitooligosaccharide 2(AUCOS2)was the most promising antifungal compound,whose highest inhibition rates were 60.12%,82.95%,and 85.23%against F.solani,V.albo-atrum and P.capsici,respectively.The synthesized derivatives have good application prospects in crop protection and deserve further research. | ZHU Jun LIU Song QIN Yukun XING Rong’e YU Huahua CHEN Xiaolin LI Pengcheng | 2020 | Journal of Oceanology and Limnology2020，38，3： | 1 |
| 9 | A High-OrderDiscontinuous GalerkinMethod for the Two-Dimensional Time-Domain Maxwell’s Equations on Curved Mesh显示文摘In this paper,a DG(Discontinuous Galerkin)method which has been widely employed in CFD(Computational Fluid Dynamics)is used to solve the twodimensional time-domain Maxwell’s equations for complex geometries on unstructured mesh.The element interfaces on solid boundary are treated in both curved way and straight way.Numerical tests are performed for both benchmark problems and complex cases with varying orders on a series of grids,where the high-order convergence in accuracy can be observed.Both the curved and the straight solid boundary implementation can give accurate RCS(Radar Cross-Section)results with sufficiently small mesh size,but the curved solid boundary implementation can significantly improve the accuracy when using relatively large mesh size.More importantly,this CFD-based high-order DG method for the Maxwell’s equations is very suitable for complex geometries. | Hongqiang Lu Yida Xu Yukun Gao Wanglong Qin Qiang Sun | 2016 | Advances in Applied Mathematics and Mechanics2016，8，1： | 1 |
| 10 | Ultrabroad-band,white light emission from carbon dot-based materials with hybrid fluorescence/phosphorescence for single component white light-emitting diodes显示文摘Benefiting from the large Stokes shift between fluorescence and phosphorescence,fluorescence/phosphorescence dual-emitting carbon dots(CDs)have gradually entered at the stage of single-phase white light-emitting diodes(WLEDs)as‘green material'.However,most of the developed dual-emitting CDs have weak phosphorescence,short emission wavelength and narrow emission band,resulting in relatively bluish white light emission and low color rendering index(CRI).Herein,an ultrabroad-band fluorescence/phosphorescence dual-emitting CD-based material(UB-CD@BA)is prepared by thermal treatment of boric acid(BA)and CDs with large conjugated structure.The stable covalent bonding between CDs and BA,as well as three-dimensional spatial restriction effect of selfpolymerization BA molecules around CDs during long-term heating efficiently rigidified the single/triplet excited states of CDs from non-radiative deactivation,thus producing strong dual emissive materials with the high phosphorescence quantum yield of 21%.Remarkable,the prepared UB-CD@BA powders exhibit bright pure white light emission with Commission Internationale de l'Eclairage(CIE)coordinates of(0.32,0.33)and the highest reported full width at half maximum of 250 nm.Based on the unique characteristics of UB-CD@BA,it was used as a color conversion layer to prepare a WLED with CIE coordinates of(0.35,0.33)and the CRI value of 87. | Yuchen Li Qijun Li Shuai Meng Yukun Qin Dengke Cheng Hailing Gu Zifei Wang Yunxia Ye Jing Tan | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 11 | Interface electronic engineering of molybdenum sulfide/MXene hybrids for highly efficient biomimetic sensors显示文摘Interface regulation plays a key role in the electrochemical performance for biosensors.By controlling the interfacial interaction,the electronic structure of active species can be adjusted effectively at micro and nano-level,which results in the optimal reaction energy barrier.Herein,we propose an interface electronic engineering scheme to design a strongly coupled 1T phase molybdenum sulfide(1T-MoS2)/MXene hybrids for constructing an efficient electrocatalytic biomimetic sensor.The local electronic and atomic structures of the 1T-MoS2/Ti3C2TX are comprehensively studied by synchrotron radiation-based X-ray photoelectron spectroscopy(XPS),as well as X-ray absorption spectroscopy(XAS)at atomic level.Experiments and theoretical calculations show that there are interfacial stresses,atomic defects and adjustable bond-length between MoS2/MXene nanosheets,which can significantly promote biomolecular adsorption and rapid electron transfer to achieve excellent electrochemical activity and reaction kinetics.The 1T-MoS2/Ti3C2TX modified electrode shows ultra high sensitivity of 1.198μA/μM for dopamine detection with low limit of 0.05μM.We anticipate that the interface electronic engineering investigation could provide a basic idea for guiding the exploration of advanced biosensors with high sensitivity and low detection limit. | Pengfei Wu Tingting You Qingyuan Ren Hongyan Xi Qingqing Liu Fengjuan Qin Hongfei Gu Yu Wang Wensheng Yan Yukun Gao Wenxing Chen Penggang Yin | 2023 | Nano Research2023，16，1： | 0 |
| 12 | Immunostimulatory eff ect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7显示文摘Hydroxypropyltrimethyl ammonium chloride chitosan(HACC)and hydroxypropyltrimethyl ammonium chloride fully deacetylated chitosan(De-HACC)were synthesized with various degrees of substitution by altering the ratio of chitosan to glycidyl trimethyl-ammonium chloride(GTMAC).The effects of the quaternary ammonium degree and the acetyl group of these polymers on immunostimulatory activities were detected in RAW 264.7 cells.The expression levels of nitrogen oxide(NO),interleukin-6(IL-6)and tumor necrosis factor(TNF-α)were compared.Results show that the removal of acetyl groups in chitosan obviously improved the degree of substitution of quaternary ammonium salts.In addition,HACC and De-HACC were capable of promoting immunological activity in a substitution-dependent manner;HACC was positively correlated,and De-HACC was negatively correlated.Among tested ratios,HACC-30%and De-HACC-54%performed better than the others,and De-HACC-54%performed the best.Generally,quaternized chitosan possesses immunostimulatory activity,which is related to the degree of quaternization and the acetyl group. | Xiaomin LI Rong’e XING Chaojie XU Song LIU Yukun QIN Kecheng LI Huahua YU Pengcheng LI | 2022 | Journal of Oceanology and Limnology2022，40，3： | 0 |
| 13 | Predicting the Growth of Ash Deposits in Drop Tube Furnace Using Dynamic Mesh Technique显示文摘Modeling and experiments of the growth of ash deposits during the combustion in a drop tube furnace are presented in this paper.An existing deposition model for ash deposit was used,which involves relationship among the force of gravity,elastic rebound and adhesion forces acting at the moment of ash particle impaction.Important parameters of this model were determined by the experimental data.The influence of particle size and velocity on deposit geometry was investigated.The growth of ash deposits involving various inlet velocities,tube diameters and tube arrangements were simulated with dynamic mesh technique in Fluent.The simulation results show that particle normal impacted velocity plays an important role due to elastic bounce force term.Deposited geometry was influenced by side velocity(velocity of inlet⁃2),and large velocity has an obvious effect to change the shape of deposition and postpone the steady time. | Krzysztof Wacławiak Hui Wang Qi Yang Xuejian Qin Yukun Qin | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，3： | 0 |
| 14 | Empirical likelihood inference and goodness-of-fit test for logistic regression model under two-phase case-control sampling显示文摘Due tocost effectiveness and hIgh efidengy.two-phase Qse control sampling has been wldely used In epldemlology studles.We dewelop a seml-parametric empinial lkellood approach to two-phase ase-control data under the logst regresslon model.we show that the maxmum empintal lklhoo estimaton has an aymptotically nomal dstibutlon,n,and the empincal lke-lthood ratlo fllws an aymptotcallycentral chi-square dstibution We find that the maxdmum empintial lkellhood estimator Is equal to Breslow and Holubkow(1997175 madimum lkelhood estimator.Evenso,the lmting dstribution of the lkelhood ratio,helhlodratlo based interval,and test are all new.Futhemmiore,we construct new Kolmogorov-smimnov type godnes-F-fit tests to test the vlldation of the undertying lglstic rgressonmodelLour simulation results and a real pplcaion show that the lola based Interval and test hawe certain mentsowver the wald-type counterparts and that the proposed godness-f-f test Is vald. | Zhen Sheng Yukun Liu Jing Qin | 2022 | Statistical Theory and Related Fields2022，6，4： | 0 |
| 15 | PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan显示文摘We previously demonstrated that 2-hydroxypropyltrimethyl ammonium chloride chitosan(HACC)promoted the production of nitric oxide(NO)and proinflammatory cytokines by activating the mitogen-activated protein kinases(MAPK)and Janus kinase(JAK)/STAT pathways in RAW 264.7 cells,indicating good immunomodulatory activity of HACC.In this study,to further investigate the immunomodulatory mechanisms of HACC,we determined the roles of phosphatidylinositol 3-kinase(PI3K)/Akt,activating protein(AP-1)and nuclear factor kappa B(NF-κB)in HACC-induced activation of RAW 264.7 cells by the western blotting.The results suggest that HACC promoted the phosphorylation of p85 and Akt.Furthermore,c-Jun and p65 were also increased after the treatment of RAW 264.7 cells with HACC,indicating the translocation of NF-κB and AP-1 from cytoplasm to nucleus.In addition,as scanning electron microscopy(SEM)analysis shows,the cell morphology changed after HACC treatment.These findings indicate that HACC activated MAPK,JAK/STAT,and PI3K/Akt signaling pathways dependent on AP-1 and NF-κB activation in RAW 264.7 cells,ultimately leading to the increase of NO and cytokines. | YANG Yue XING Rong’e LIU Song QIN Yukun LI Kecheng YU Huahua LI Pengcheng | 2020 | Journal of Oceanology and Limnology2020，38，3： | 0 |
| 16 | A selective review of statistical methods using calibration information from similar studies显示文摘In the era of big data,divide-and-conquer,parallel,and distributed inference methods have become increasingly popular.How to effectively use the calibration information from each machine in parallel computation has become a challenging task for statisticians and computer scientists.Many newly developed methods have roots in traditional statistical approaches that make use of calibration information.In this paper,we first review some classical statistical methods for using calibration information,including simple meta-analysis methods,parametric likelihood,empirical likelihood,and the generalized method of moments.We further investigate how these methods incorporate summarized or auxiliary information from previous studies,related studies,or populations.We find that the methods based on summarized data usually have little or nearly no efficiency loss compared with the corresponding methods based on all-individual data.Finally,we review some recently developed big data analysis methods including communication-efficient distributed approaches,renewal estimation,and incremental inference as examples of the latest developments in methods using calibration information. | Jing Qin Yukun Liu Pengfei Li | 2022 | Statistical Theory and Related Fields2022，6，3： | 0 |
| 17 | Rejoinder on“A selective review of statistical methods using calibration information from similar studies”显示文摘We thank Professor Jun Shao for organizing this interesting discussion.We also thank the six discussants formany insightful comments and suggestions.Assembling data from different sources has been becoming a very popular topic nowadays.In our review paper,we have mainly discussed many integration methods when internal data and external data share a common distribution,though the external data may not have information for some underlying variables collected in the internal study. | Jing Qin Yukun Liu Pengfei Li | 2022 | Statistical Theory and Related Fields2022，6，3： | 0 |
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