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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Oestrogen replacement therapy promotes hone healing around dental implants in osteoporotic rats显示文摘 | Qi MC Zhou XQ Hu J | 2004 | Int J Oral Maxillofac Surg2004，33，3： | 1 |
| 3 | Callus formation enhanced by BMP7 ex vivo gene therapy during distraction osteogenesis in rats显示文摘 | Hu J Qi MC Zou SJ | 2007 | J Orthop Res2007，25，2： | 1 |
| 4 | O estrogen replacement therapy promotes bone healing around dental implants in osteoporotic rats显示文摘 | Qi MC Zhou XQ Hu J | 2004 | Int J Oral Maxilofac Surg2004，33，3： | 1 |
| 5 | Callus formation enhanced by BMP -7 ex vivo gene therapy during distraction osteogenesis in rats显示文摘 | Hu J Qi MC Zou SJ | 2007 | J Orthop Res2007，25，2： | 1 |
| 6 | Mechanical strain induces osteogenic differentiation: Cbfal and Ets-1 expression in stretched rat mesenchymal stem ceils 显示文摘 | Qi MC Hu J Zou SJ | 2008 | Int J Oral Maxillofac Surg2008，37，5： | 1 |
| 7 | Live/real time three-dimensional transthoracic echocardiographic assessment of leftventricular volumes, ejection fraction, and mass compared withmagnetic resonance imaging显示文摘 | Qi X Cogar B Hsiung MC | 2007 | Echocardiography2007，24，： | 1 |
| 8 | Callus formation enhanced by BMP ex vivo gene therapy during distraction osteosgenesis in rats显示文摘 | Hu J Qi MC Zou SJ | | 0，，02： | 1 |
| 9 | Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes显示文摘 | Qi L Cornelis MC Kraft P | | 0，，： | 1 |
| 10 | Mechanical strain induces osteogenic differentiation: Cbfal and Ets-I expression in stretched rat mesenchymal stem cells显示文摘 | Qi MC Hu J Zou SJ | 2008 | Int J Oral Maxillofac Surg2008，37，5： | 1 |
| 11 | Oestrogen replacement thera- py promotes bone healing around dental implants in osteoporotic rats显示文摘 | Qi MC Zhou XQ Hu J | 2004 | Int J Oral Maxillofac Surg2004，33，3： | 1 |
| 12 | Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats显示文摘 | Hu J Qi MC Zou SJ | 2007 | J Orthop Res2007，25，2： | 1 |
| 13 | Cal us formation enhanced by BMP ex vivo gene therapy during distraction osteosgenesis in rats显示文摘 | Hu J Qi MC Zou SJ | | 0，，02： | 1 |
| 14 | Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes显示文摘 | Qi L Cornelis MC Kraft P | 2010 | Hum Mol Genet2010，19，13： | 1 |
| 15 | Mechanical strain induces osteo genie differentiation: Cbfal and Ets-1 expression in stretched rat mesenchymal stem cells 显示文摘 | Qi MC Hu J Zou SJ | 2008 | Int Oral Maxillofac Surg2008，37，： | 1 |
| 16 | Callus formation enhanced by BMP-7 ex Vivo gene therapy during distraction osteogenesis in rats显示文摘 | Hu J Qi MC Zou SJ | | 0，，02： | 1 |
| 17 | Predictive value of serum parathyroid hormone levels for bone turnover in patients on chronic maintenance dialysis显示文摘 | Monier-Faugere MC Geng Z | 1995 | Am J Kidney Dis1995，26，4： | 1 |
| 18 | Modeling the neurovascular niche: VEGF - and BDNF - mediated cross- talk between neural stem cells and endothelial cells: an in vitro study 显示文摘 | Li Qi Ford MC Lavik EB | 2006 | J Neurosci Res2006，84，8： | 1 |
| 19 | Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1 expression in stretched rat mesenchymal stem cells显示文摘 | Qi MC Hu J Zou SJ | 2008 | Int J Oral Maxillofac Surg2008，37，5： | 1 |
| 20 | Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets -1 expression in stretched rat mesenchymal stem cells显示文摘 | Qi MC Hu J Zou SJ | 2008 | Int J Oral Maxillofac Surg2008，37，5： | 1 |
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