|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and experimental study of oxaliplatin in treating human gastric carcinoma显示文摘AIM: To evaluate the therapeutic effectiveness of oxaliplatinon human gastric carcinoma and to explore its mechanisms.METHODS: Twenty-two cases of stage IV gastric carcinomareceived 4-6 (mean 4.6) cycles of first line combinedchemotherapy with oxaliplatin (oxaliplatin 85 mg/m^2, iv, gtt,1 h, d 1; leukovorin 200 mg/m^2, iv, gtt, 1 h, d 1 and d 2; 5-FU 300 mg/m^2,iv, d I and d 2, 5-FU, continuous iv, gtt, 48 h;1 cycle/2 wk). Response rate, progression-free survival(PFS), total survival time, toxic side effects were evaluated.The inhibitory effect of oxaliplatin on human gastric cell lineSGC-7901 was detected and ICs0 was calculated by MTT.Transmission electron microscopy, flow cytometry andTUNEL were performed to evaluate the apoptosis of cellline induced by the drug. The expression of Caspase-3m-RNA was detected by RT-PCR. AC-DEVD-CHO, aCaspase-3 specific inhibitor, was used to elucidate the roleof activated Caspase-3 in the process of apoptosis inducedby oxaliplatin.RESULTS: Total response (complete and partial) occurredin 9 (40.9%) patients. Mean PFS was 4.2 mo and meantotal survival time was 7.2 mo. Cumulative neurotoxicity(all grade I-II), vomiting and diarrhea, myelosuppressionappeared in 93.5%, 20%, 32.9% patients, respectively.ICs0 was calculated to be 0.71 mg/L by Ml-r assay. A maximalinhibitory rate reached 85.3%. Apoptosis index was elevatedafter incubated with 1 mmol/L oxaliplatin for 30 rain, butwithout statistic significance (P>0.05). However it couldbe detected at a much higher degree both by fiowcytometryand by TUNEL with a statistical significance (68.47+7.92%and 8.23+2.67%, respectively, P<0.05) at^er incubated withi mmol/L oxaliplatin for 2 d. By means of RT-PCR, we detectedan enhancement of Caspase-3 m-RNA expression inducedby oxaliplatin which was also in positive correlation withthe apoptotic level. AC-DEVD-CHO, a Caspase-3 specificinhibitor, could significantly inhibit and delay apoptosisinduced by oxaliplatin.CONCLUSION: Oxaliplatin is effective and well-toleratedin patients with advanced gastric carcinoma. Oxaliplatincould significantly inhibit the growth of human gastric cell lineSGC-7901. The induction of Caspase-3 m-RNA expression,activation of Caspase-3 and promotion of apoptosis maybe some of the therapeutic mechanisms of oxaliplatin ongastric carcinoma. Annexin-V-fluorescein labeling flowcytometry is much more sensitive than TUNEL in detectingearly stage apoptosis. | Wan-LongLin Ding-GuoLi QiangChen Han-MingLu | 2004 | World Journal of Gastroenterology2004，10，19： | 21 |
| 2 | MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS——A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES显示文摘N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane) (SPEU) and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR, XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro, the two materials studied, including poly-DMMCA gel, all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility. | JunZhou Yong-zhiQiu Xiao-pengZang Chang-wangPan QiangChen JianShen Si-congLin | 2005 | Chinese Journal of Polymer Science2005，23，1： | 2 |
| 3 | Inhibition of hepatitis B Virus replication by hepatocyte nuclear factor 4‐alpha specific short hairpin RNA显示文摘 | En‐QiangChen Tao‐YouZhou XingCheng HongTang | 2012 | Liver Int2012，，5： | 1 |
| 4 | Grainrefinementin an as-cast AZ61magnesium alloy processed by multi-axial forging under the multi temperature processing procedure 显示文摘 | QiangChen DayuShua ChuankaiHua etal | 2012 | Materials Science and Engineering: A2012，541，15： | 1 |
| 5 | 基于同质的图版去噪[J]显示文摘 | QiangChen QuansenSun DeshenXia | | 模式识别0，，： | 1 |
| 6 | 基于依赖性分析的类内聚度度量显示文摘软件系统开发时应遵循“高内聚、低耦合”的软件工程原则,但内聚度本身是主观的、非形式化的概念,程序设计人员很难客观地评估一个模块的内聚度。在面向对象系统中,内聚度主要是指类内部各成份之间的联结强度。 | Zhen—QiangChen Bao-WenXu Yu-MingZhou | 2004 | Journal of Computer Science & Technology2004，19，C00： | 0 |
| 7 | Optimal Allocation of Public Transport Hub Based on Load Loss Value and the Economy of Distribution Network显示文摘The rapid development of electric buses has brought a surge in the number of bus hubs and their charging and discharging capacities.Therefore,the location and construction scale of bus hubs will greatly affect the operation costs and benefits of an urban distribution network in the future.Through the scientific and reasonable planning of public transport hubs on the premise of meeting the needs of basic public transport services,it can reduce the negative impact of electric bus charging loads upon the power grids.Furthermore,it can use its flexible operation characteristics to provide flexible support for the distribution network.In this paper,taking the impact of public transport hub on the reliability of distribution network as the starting point,a three-level programming optimization model based on the value and economy of distribution network load loss is proposed.Through the upper model,several planning schemes can be generated,which provides boundary conditions for the expansion of middle-level optimization.The normal operation dispatching scheme of public transport hub obtained from the middle-level optimization results provides boundary conditions for the development of lower level optimization.Through the lower level optimization,the expected load loss of the whole distribution system including bus hub under the planning scheme given by the upper level can be obtained.The effectiveness of the model is verified by an IEEE-33 bus example. | Yuying Zhang Chen Liang Bo Sun QiangChen Mingyang Lei | 2022 | Energy Engineering2022，119，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员